Manganese transport across the blood-brain barrier: Relationship to iron homeostasis

Michael Aschner, Judy L. Aschner

Research output: Contribution to journalArticle

131 Scopus citations

Abstract

The binding characteristics of manganese (Mn) to transferrin (Tf) were examined on G-75 Sephadex gel columns. When 54MnCl2 was combined with Tf and immediately fractionated on the Sephadex column, 49% of 54Mn was bound to Tf. The fraction of 54Mn which was Tf-bound was dependent upon the incubation period, and increased in a time-dependent fashion. In vivo, 6 hr of intravenous administration of ferric-hydroxide dextran complex significantly inhibited (p<0.05)54Mn brain uptake as compared to its uptake in iron-free dextran-treated rats. These results suggest that iron (Fe) homeostasis may play an important role in the regulation of Mn transport across the blood-brain barrier (BBB).

Original languageEnglish (US)
Pages (from-to)857-860
Number of pages4
JournalBrain Research Bulletin
Volume24
Issue number6
DOIs
StatePublished - Jun 1990

Keywords

  • Blood-brain barrier
  • Iron
  • Manganese
  • Rat
  • Transferrin
  • Transport

ASJC Scopus subject areas

  • Neuroscience(all)

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