Abstract
The binding characteristics of manganese (Mn) to transferrin (Tf) were examined on G-75 Sephadex gel columns. When 54MnCl2 was combined with Tf and immediately fractionated on the Sephadex column, 49% of 54Mn was bound to Tf. The fraction of 54Mn which was Tf-bound was dependent upon the incubation period, and increased in a time-dependent fashion. In vivo, 6 hr of intravenous administration of ferric-hydroxide dextran complex significantly inhibited (p<0.05)54Mn brain uptake as compared to its uptake in iron-free dextran-treated rats. These results suggest that iron (Fe) homeostasis may play an important role in the regulation of Mn transport across the blood-brain barrier (BBB).
Original language | English (US) |
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Pages (from-to) | 857-860 |
Number of pages | 4 |
Journal | Brain Research Bulletin |
Volume | 24 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1990 |
Externally published | Yes |
Keywords
- Blood-brain barrier
- Iron
- Manganese
- Rat
- Transferrin
- Transport
ASJC Scopus subject areas
- General Neuroscience