Manganese toxicity and the glutamine-glutamate cycle

Marta Sidoryk-Wegrzynowicz, Michael Aschner

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Glutamine (Gln) is abundantly expressed in the central nervous system (CNS), where it participates in a variety of metabolic pathways. Gln metabolism proceeds via the glutamine/glutamate (Glu)-γ-aminobutyric acid (GABA) cycle (GGC), and the reactions within this cycle are carried out both in astrocytic and neuronal compartments. The GGC appears to have an important, albeit not exclusive role, in the recycling of Glu and GABA. Disruption of GGC between astrocytes and neurons contributes to changes in Glu-ergic and/or GABA-ergic transmission, and is associated with several neuropathological conditions, including manganese (Mn) toxicity.

Original languageEnglish (US)
Title of host publicationGlutamine in Clinical Nutrition
PublisherSpringer New York
Number of pages13
ISBN (Print)9781493919321, 9781493919314
Publication statusPublished - Jan 1 2015



  • Glutamate
  • Glutamine
  • Manganese
  • Neurotoxicity
  • PKC signaling
  • Transporter
  • Ubiquitination

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Agricultural and Biological Sciences(all)

Cite this

Sidoryk-Wegrzynowicz, M., & Aschner, M. (2015). Manganese toxicity and the glutamine-glutamate cycle. In Glutamine in Clinical Nutrition (pp. 401-413). Springer New York.