Manganese: Recent advances in understanding its transport and neurotoxicity

Michael Aschner; Tomás R. Guilarte; Jay S. Schneider; Wei Zheng

doi:10.1016/j.taap.2007.03.001

Manganese: Recent advances in understanding its transport and neurotoxicity

Michael Aschner, Tomás R. Guilarte, Jay S. Schneider, Wei Zheng

Research output: Contribution to journal › Review article › peer-review

522 Scopus citations

Abstract

The present review is based on presentations from the meeting of the Society of Toxicology in San Diego, CA (March 2006). It addresses recent developments in the understanding of the transport of manganese (Mn) into the central nervous system (CNS), as well as brain imaging and neurocognitive studies in non-human primates aimed at improving our understanding of the mechanisms of Mn neurotoxicity. Finally, we discuss potential therapeutic modalities for treating Mn intoxication in humans.

Original language	English (US)
Pages (from-to)	131-147
Number of pages	17
Journal	Toxicology and Applied Pharmacology
Volume	221
Issue number	2
DOIs	https://doi.org/10.1016/j.taap.2007.03.001
State	Published - Jun 1 2007
Externally published	Yes

Keywords

Manganese
Neurotoxicity
Parkinson's disease
Transport

ASJC Scopus subject areas

Toxicology
Pharmacology

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10.1016/j.taap.2007.03.001

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title = "Manganese: Recent advances in understanding its transport and neurotoxicity",

abstract = "The present review is based on presentations from the meeting of the Society of Toxicology in San Diego, CA (March 2006). It addresses recent developments in the understanding of the transport of manganese (Mn) into the central nervous system (CNS), as well as brain imaging and neurocognitive studies in non-human primates aimed at improving our understanding of the mechanisms of Mn neurotoxicity. Finally, we discuss potential therapeutic modalities for treating Mn intoxication in humans.",

keywords = "Manganese, Neurotoxicity, Parkinson's disease, Transport",

author = "Michael Aschner and Guilarte, {Tom{\'a}s R.} and Schneider, {Jay S.} and Wei Zheng",

note = "Funding Information: This work was supported in part by NIEHS 10563 and DoD W81XWH-05-1-0239 (MA), NIEHS 010975 (TRG), NIEHS10975 (JSS) and NIEHS 008146 (WZ).",

year = "2007",

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doi = "10.1016/j.taap.2007.03.001",

language = "English (US)",

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T2 - Recent advances in understanding its transport and neurotoxicity

AU - Aschner, Michael

AU - Guilarte, Tomás R.

AU - Schneider, Jay S.

AU - Zheng, Wei

N1 - Funding Information: This work was supported in part by NIEHS 10563 and DoD W81XWH-05-1-0239 (MA), NIEHS 010975 (TRG), NIEHS10975 (JSS) and NIEHS 008146 (WZ).

PY - 2007/6/1

Y1 - 2007/6/1

N2 - The present review is based on presentations from the meeting of the Society of Toxicology in San Diego, CA (March 2006). It addresses recent developments in the understanding of the transport of manganese (Mn) into the central nervous system (CNS), as well as brain imaging and neurocognitive studies in non-human primates aimed at improving our understanding of the mechanisms of Mn neurotoxicity. Finally, we discuss potential therapeutic modalities for treating Mn intoxication in humans.

AB - The present review is based on presentations from the meeting of the Society of Toxicology in San Diego, CA (March 2006). It addresses recent developments in the understanding of the transport of manganese (Mn) into the central nervous system (CNS), as well as brain imaging and neurocognitive studies in non-human primates aimed at improving our understanding of the mechanisms of Mn neurotoxicity. Finally, we discuss potential therapeutic modalities for treating Mn intoxication in humans.

KW - Manganese

KW - Neurotoxicity

KW - Parkinson's disease

KW - Transport

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JO - Toxicology and Applied Pharmacology

JF - Toxicology and Applied Pharmacology

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ER -

Manganese: Recent advances in understanding its transport and neurotoxicity

Abstract

Keywords

ASJC Scopus subject areas

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