Manganese: Recent advances in understanding its transport and neurotoxicity

Michael Aschner, Tomás R. Guilarte, Jay S. Schneider, Wei Zheng

Research output: Contribution to journalReview article

423 Scopus citations

Abstract

The present review is based on presentations from the meeting of the Society of Toxicology in San Diego, CA (March 2006). It addresses recent developments in the understanding of the transport of manganese (Mn) into the central nervous system (CNS), as well as brain imaging and neurocognitive studies in non-human primates aimed at improving our understanding of the mechanisms of Mn neurotoxicity. Finally, we discuss potential therapeutic modalities for treating Mn intoxication in humans.

Original languageEnglish (US)
Pages (from-to)131-147
Number of pages17
JournalToxicology and Applied Pharmacology
Volume221
Issue number2
DOIs
StatePublished - Jun 1 2007
Externally publishedYes

Keywords

  • Manganese
  • Neurotoxicity
  • Parkinson's disease
  • Transport

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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