Manganese neurotoxicity and the role of reactive oxygen species

Ebany J. Martinez-Finley, Claire E. Gavin, Michael Aschner, Thomas E. Gunter

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Manganese (Mn) is an essential dietary nutrient, but an excess or accumulation can be toxic. Disease states, such as manganism, are associated with overexposure or accumulation of Mn and are due to the production of reactive oxygen species, free radicals, and toxic metabolites; alteration of mitochondrial function and ATP production; and depletion of cellular antioxidant defense mechanisms. This review focuses on all of the preceding mechanisms and the scientific studies that support them as well as providing an overview of the absorption, distribution, and excretion of Mn and the stability and transport of Mn compounds in the body.

Original languageEnglish (US)
Pages (from-to)65-75
Number of pages11
JournalFree Radical Biology and Medicine
Volume62
DOIs
StatePublished - 2013
Externally publishedYes

Fingerprint

Manganese
Reactive Oxygen Species
Poisons
Manganese Compounds
Metabolites
Nutrients
Free Radicals
Antioxidants
Adenosine Triphosphate
Food

Keywords

  • DA autoxidation
  • Free radicals
  • Manganese
  • Manganism
  • Mitochondrial dysfunction
  • Reactive oxygen species

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

Cite this

Manganese neurotoxicity and the role of reactive oxygen species. / Martinez-Finley, Ebany J.; Gavin, Claire E.; Aschner, Michael; Gunter, Thomas E.

In: Free Radical Biology and Medicine, Vol. 62, 2013, p. 65-75.

Research output: Contribution to journalArticle

Martinez-Finley, Ebany J. ; Gavin, Claire E. ; Aschner, Michael ; Gunter, Thomas E. / Manganese neurotoxicity and the role of reactive oxygen species. In: Free Radical Biology and Medicine. 2013 ; Vol. 62. pp. 65-75.
@article{374ff7fa5c084805a80e4818de43d630,
title = "Manganese neurotoxicity and the role of reactive oxygen species",
abstract = "Manganese (Mn) is an essential dietary nutrient, but an excess or accumulation can be toxic. Disease states, such as manganism, are associated with overexposure or accumulation of Mn and are due to the production of reactive oxygen species, free radicals, and toxic metabolites; alteration of mitochondrial function and ATP production; and depletion of cellular antioxidant defense mechanisms. This review focuses on all of the preceding mechanisms and the scientific studies that support them as well as providing an overview of the absorption, distribution, and excretion of Mn and the stability and transport of Mn compounds in the body.",
keywords = "DA autoxidation, Free radicals, Manganese, Manganism, Mitochondrial dysfunction, Reactive oxygen species",
author = "Martinez-Finley, {Ebany J.} and Gavin, {Claire E.} and Michael Aschner and Gunter, {Thomas E.}",
year = "2013",
doi = "10.1016/j.freeradbiomed.2013.01.032",
language = "English (US)",
volume = "62",
pages = "65--75",
journal = "Free Radical Biology and Medicine",
issn = "0891-5849",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Manganese neurotoxicity and the role of reactive oxygen species

AU - Martinez-Finley, Ebany J.

AU - Gavin, Claire E.

AU - Aschner, Michael

AU - Gunter, Thomas E.

PY - 2013

Y1 - 2013

N2 - Manganese (Mn) is an essential dietary nutrient, but an excess or accumulation can be toxic. Disease states, such as manganism, are associated with overexposure or accumulation of Mn and are due to the production of reactive oxygen species, free radicals, and toxic metabolites; alteration of mitochondrial function and ATP production; and depletion of cellular antioxidant defense mechanisms. This review focuses on all of the preceding mechanisms and the scientific studies that support them as well as providing an overview of the absorption, distribution, and excretion of Mn and the stability and transport of Mn compounds in the body.

AB - Manganese (Mn) is an essential dietary nutrient, but an excess or accumulation can be toxic. Disease states, such as manganism, are associated with overexposure or accumulation of Mn and are due to the production of reactive oxygen species, free radicals, and toxic metabolites; alteration of mitochondrial function and ATP production; and depletion of cellular antioxidant defense mechanisms. This review focuses on all of the preceding mechanisms and the scientific studies that support them as well as providing an overview of the absorption, distribution, and excretion of Mn and the stability and transport of Mn compounds in the body.

KW - DA autoxidation

KW - Free radicals

KW - Manganese

KW - Manganism

KW - Mitochondrial dysfunction

KW - Reactive oxygen species

UR - http://www.scopus.com/inward/record.url?scp=84884905903&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884905903&partnerID=8YFLogxK

U2 - 10.1016/j.freeradbiomed.2013.01.032

DO - 10.1016/j.freeradbiomed.2013.01.032

M3 - Article

VL - 62

SP - 65

EP - 75

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

SN - 0891-5849

ER -