Manganese neurotoxicity and the role of reactive oxygen species

Ebany J. Martinez-Finley; Claire E. Gavin; Michael Aschner; Thomas E. Gunter

doi:10.1016/j.freeradbiomed.2013.01.032

Manganese neurotoxicity and the role of reactive oxygen species

Ebany J. Martinez-Finley, Claire E. Gavin, Michael Aschner, Thomas E. Gunter

Research output: Contribution to journal › Review article › peer-review

240 Scopus citations

Abstract

Manganese (Mn) is an essential dietary nutrient, but an excess or accumulation can be toxic. Disease states, such as manganism, are associated with overexposure or accumulation of Mn and are due to the production of reactive oxygen species, free radicals, and toxic metabolites; alteration of mitochondrial function and ATP production; and depletion of cellular antioxidant defense mechanisms. This review focuses on all of the preceding mechanisms and the scientific studies that support them as well as providing an overview of the absorption, distribution, and excretion of Mn and the stability and transport of Mn compounds in the body.

Original language	English (US)
Pages (from-to)	65-75
Number of pages	11
Journal	Free Radical Biology and Medicine
Volume	62
DOIs	https://doi.org/10.1016/j.freeradbiomed.2013.01.032
State	Published - 2013
Externally published	Yes

Keywords

DA autoxidation
Free radicals
Manganese
Manganism
Mitochondrial dysfunction
Reactive oxygen species

ASJC Scopus subject areas

Biochemistry
Physiology (medical)

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10.1016/j.freeradbiomed.2013.01.032

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title = "Manganese neurotoxicity and the role of reactive oxygen species",

abstract = "Manganese (Mn) is an essential dietary nutrient, but an excess or accumulation can be toxic. Disease states, such as manganism, are associated with overexposure or accumulation of Mn and are due to the production of reactive oxygen species, free radicals, and toxic metabolites; alteration of mitochondrial function and ATP production; and depletion of cellular antioxidant defense mechanisms. This review focuses on all of the preceding mechanisms and the scientific studies that support them as well as providing an overview of the absorption, distribution, and excretion of Mn and the stability and transport of Mn compounds in the body.",

keywords = "DA autoxidation, Free radicals, Manganese, Manganism, Mitochondrial dysfunction, Reactive oxygen species",

author = "Martinez-Finley, {Ebany J.} and Gavin, {Claire E.} and Michael Aschner and Gunter, {Thomas E.}",

year = "2013",

doi = "10.1016/j.freeradbiomed.2013.01.032",

language = "English (US)",

volume = "62",

pages = "65--75",

journal = "Free Radical Biology and Medicine",

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T1 - Manganese neurotoxicity and the role of reactive oxygen species

AU - Martinez-Finley, Ebany J.

AU - Gavin, Claire E.

AU - Aschner, Michael

AU - Gunter, Thomas E.

PY - 2013

Y1 - 2013

N2 - Manganese (Mn) is an essential dietary nutrient, but an excess or accumulation can be toxic. Disease states, such as manganism, are associated with overexposure or accumulation of Mn and are due to the production of reactive oxygen species, free radicals, and toxic metabolites; alteration of mitochondrial function and ATP production; and depletion of cellular antioxidant defense mechanisms. This review focuses on all of the preceding mechanisms and the scientific studies that support them as well as providing an overview of the absorption, distribution, and excretion of Mn and the stability and transport of Mn compounds in the body.

AB - Manganese (Mn) is an essential dietary nutrient, but an excess or accumulation can be toxic. Disease states, such as manganism, are associated with overexposure or accumulation of Mn and are due to the production of reactive oxygen species, free radicals, and toxic metabolites; alteration of mitochondrial function and ATP production; and depletion of cellular antioxidant defense mechanisms. This review focuses on all of the preceding mechanisms and the scientific studies that support them as well as providing an overview of the absorption, distribution, and excretion of Mn and the stability and transport of Mn compounds in the body.

KW - DA autoxidation

KW - Free radicals

KW - Manganese

KW - Manganism

KW - Mitochondrial dysfunction

KW - Reactive oxygen species

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DO - 10.1016/j.freeradbiomed.2013.01.032

M3 - Review article

C2 - 23395780

AN - SCOPUS:84884905903

SN - 0891-5849

VL - 62

SP - 65

EP - 75

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

ER -

Manganese neurotoxicity and the role of reactive oxygen species

Abstract

Keywords

ASJC Scopus subject areas

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