Manganese neurotoxicity

Daiana Silva Ávila, Robson Luiz Puntel, Vanderlei Folmer, João Batista Teixeira Rocha, Ana Paula Marreilha dos Santos, Michael Aschner

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Over the past years there has been considerable progress in our understanding of manganese (Mn)-induced neurotoxicity and its mechanisms. These studies led to changes in Mn safety assessment around the world. However, manganism continues to represent a health concern, especially considering the recent findings linking manganism to Parkinson's disease (PD). Animal models have been invaluable in these investigations. Findings from these studies are discussed in this chapter within the context of Mn-induced neurotoxicity mechanisms and its role in the etiology of parkinsonism.

Original languageEnglish (US)
Title of host publicationHandbook of Neurotoxicity
PublisherSpringer New York
Pages843-864
Number of pages22
Volume2
ISBN (Electronic)9781461458364
ISBN (Print)9781461458357
DOIs
StatePublished - Jan 1 2014

Keywords

  • Dopamine
  • Manganese
  • Neurotoxicity
  • Parkinson's disease

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

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  • Cite this

    Ávila, D. S., Puntel, R. L., Folmer, V., Rocha, J. B. T., dos Santos, A. P. M., & Aschner, M. (2014). Manganese neurotoxicity. In Handbook of Neurotoxicity (Vol. 2, pp. 843-864). Springer New York. https://doi.org/10.1007/978-1-4614-5836-4_3