Manganese (Mn) and iron (Fe): Interdependency of transport and regulation

Vanessa A. Fitsanakis, Na Zhang, Stephanie Garcia, Michael Aschner

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Manganese (Mn) and iron (Fe) are transition metals that are crucial to the appropriate growth, development, function, and maintenance of biological organisms. Because of their chemical similarity, in organisms ranging from bacteria to mammals they share and compete for many protein transporters, such as the divalent metal transporter-1. As such, during conditions of low Fe, abnormal Mn accumulation occurs. Conversely, when Mn concentrations are altered, the homeostasis and deposition of Fe and other transition metals are disrupted. Our lab has undertaken a series of studies in rats involving pregnant dams, neo- and perinatal pups, and adult animals. Animals were exposed to various concentrations of dietary Fe and/or Mn, and protein transporter expression, blood Mn and Fe concentrations, brain transition metal concentrations, and temporal brain deposition patterns were examined. As a result, we have demonstrated the importance of the interdependence of the transport of Mn and Fe, and established brain metal concentrations in several longitudinal studies. The purpose of this review is to examine these studies in their entirety and highlight the importance of monitoring the deposition and accumulation of both Mn and Fe when designing future studies related to either dietary or environmental changes in transition metal levels. Finally, this review will provide information about various transport proteins currently under investigation in the research community related to Fe and Mn regulation and transport.

Original languageEnglish (US)
Pages (from-to)124-131
Number of pages8
JournalNeurotoxicity Research
Volume18
Issue number2
DOIs
StatePublished - 2010
Externally publishedYes

Fingerprint

Manganese
Iron
Metals
Transition metals
Brain
Animals
Mammals
Growth and Development
Dams
Longitudinal Studies
Rats
Bacteria
Carrier Proteins
Proteins
Homeostasis
Blood
Monitoring
Research

Keywords

  • Dietary alterations
  • Iron
  • Manganese
  • Metal homeostasis
  • Metal transport proteins

ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology

Cite this

Manganese (Mn) and iron (Fe) : Interdependency of transport and regulation. / Fitsanakis, Vanessa A.; Zhang, Na; Garcia, Stephanie; Aschner, Michael.

In: Neurotoxicity Research, Vol. 18, No. 2, 2010, p. 124-131.

Research output: Contribution to journalArticle

Fitsanakis, Vanessa A. ; Zhang, Na ; Garcia, Stephanie ; Aschner, Michael. / Manganese (Mn) and iron (Fe) : Interdependency of transport and regulation. In: Neurotoxicity Research. 2010 ; Vol. 18, No. 2. pp. 124-131.
@article{21ffc77c8967463e99f76eae70bf158f,
title = "Manganese (Mn) and iron (Fe): Interdependency of transport and regulation",
abstract = "Manganese (Mn) and iron (Fe) are transition metals that are crucial to the appropriate growth, development, function, and maintenance of biological organisms. Because of their chemical similarity, in organisms ranging from bacteria to mammals they share and compete for many protein transporters, such as the divalent metal transporter-1. As such, during conditions of low Fe, abnormal Mn accumulation occurs. Conversely, when Mn concentrations are altered, the homeostasis and deposition of Fe and other transition metals are disrupted. Our lab has undertaken a series of studies in rats involving pregnant dams, neo- and perinatal pups, and adult animals. Animals were exposed to various concentrations of dietary Fe and/or Mn, and protein transporter expression, blood Mn and Fe concentrations, brain transition metal concentrations, and temporal brain deposition patterns were examined. As a result, we have demonstrated the importance of the interdependence of the transport of Mn and Fe, and established brain metal concentrations in several longitudinal studies. The purpose of this review is to examine these studies in their entirety and highlight the importance of monitoring the deposition and accumulation of both Mn and Fe when designing future studies related to either dietary or environmental changes in transition metal levels. Finally, this review will provide information about various transport proteins currently under investigation in the research community related to Fe and Mn regulation and transport.",
keywords = "Dietary alterations, Iron, Manganese, Metal homeostasis, Metal transport proteins",
author = "Fitsanakis, {Vanessa A.} and Na Zhang and Stephanie Garcia and Michael Aschner",
year = "2010",
doi = "10.1007/s12640-009-9130-1",
language = "English (US)",
volume = "18",
pages = "124--131",
journal = "Neurotoxicity Research",
issn = "1029-8428",
publisher = "Springer New York",
number = "2",

}

TY - JOUR

T1 - Manganese (Mn) and iron (Fe)

T2 - Interdependency of transport and regulation

AU - Fitsanakis, Vanessa A.

AU - Zhang, Na

AU - Garcia, Stephanie

AU - Aschner, Michael

PY - 2010

Y1 - 2010

N2 - Manganese (Mn) and iron (Fe) are transition metals that are crucial to the appropriate growth, development, function, and maintenance of biological organisms. Because of their chemical similarity, in organisms ranging from bacteria to mammals they share and compete for many protein transporters, such as the divalent metal transporter-1. As such, during conditions of low Fe, abnormal Mn accumulation occurs. Conversely, when Mn concentrations are altered, the homeostasis and deposition of Fe and other transition metals are disrupted. Our lab has undertaken a series of studies in rats involving pregnant dams, neo- and perinatal pups, and adult animals. Animals were exposed to various concentrations of dietary Fe and/or Mn, and protein transporter expression, blood Mn and Fe concentrations, brain transition metal concentrations, and temporal brain deposition patterns were examined. As a result, we have demonstrated the importance of the interdependence of the transport of Mn and Fe, and established brain metal concentrations in several longitudinal studies. The purpose of this review is to examine these studies in their entirety and highlight the importance of monitoring the deposition and accumulation of both Mn and Fe when designing future studies related to either dietary or environmental changes in transition metal levels. Finally, this review will provide information about various transport proteins currently under investigation in the research community related to Fe and Mn regulation and transport.

AB - Manganese (Mn) and iron (Fe) are transition metals that are crucial to the appropriate growth, development, function, and maintenance of biological organisms. Because of their chemical similarity, in organisms ranging from bacteria to mammals they share and compete for many protein transporters, such as the divalent metal transporter-1. As such, during conditions of low Fe, abnormal Mn accumulation occurs. Conversely, when Mn concentrations are altered, the homeostasis and deposition of Fe and other transition metals are disrupted. Our lab has undertaken a series of studies in rats involving pregnant dams, neo- and perinatal pups, and adult animals. Animals were exposed to various concentrations of dietary Fe and/or Mn, and protein transporter expression, blood Mn and Fe concentrations, brain transition metal concentrations, and temporal brain deposition patterns were examined. As a result, we have demonstrated the importance of the interdependence of the transport of Mn and Fe, and established brain metal concentrations in several longitudinal studies. The purpose of this review is to examine these studies in their entirety and highlight the importance of monitoring the deposition and accumulation of both Mn and Fe when designing future studies related to either dietary or environmental changes in transition metal levels. Finally, this review will provide information about various transport proteins currently under investigation in the research community related to Fe and Mn regulation and transport.

KW - Dietary alterations

KW - Iron

KW - Manganese

KW - Metal homeostasis

KW - Metal transport proteins

UR - http://www.scopus.com/inward/record.url?scp=77956709806&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956709806&partnerID=8YFLogxK

U2 - 10.1007/s12640-009-9130-1

DO - 10.1007/s12640-009-9130-1

M3 - Article

C2 - 19921534

AN - SCOPUS:77956709806

VL - 18

SP - 124

EP - 131

JO - Neurotoxicity Research

JF - Neurotoxicity Research

SN - 1029-8428

IS - 2

ER -