Manganese: Its Role in Disease and Health

Keith M. Erikson, Michael Aschner

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Manganese is an essential dietary element that functions primarily as a coenzyme in several biological processes. These processes include, but are not limited to, macronutrient metabolism, bone formation, free radical defense systems, and in the brain, ammonia clearance and neurotransmitter synthesis. It is a critical component in dozens of proteins and enzymes, and is found in all tissues. Concentrated levels of Mn are found in tissues rich in mitochondria and melanin, with both, liver, and pancreas having the highest concentrations under normal conditions. However, overexposure to environmental Mn via industrial occupation or contaminated drinking water can lead to toxic brain Mn accumulation that has been associated with neurological impairment. The objective of this chapter is to address the biological importance of Mn (essentiality), routes of exposure, factors dictating Mn status, a brief discussion of Mn neurotoxicity, and proposed methods for neurotoxicity remediation.

Original languageEnglish (US)
JournalMetal ions in life sciences
Volume19
DOIs
StatePublished - Jan 14 2019

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Manganese
Biological Phenomena
Poisons
Coenzymes
Melanins
Health
Brain
Occupations
Ammonia
Osteogenesis
Drinking Water
Free Radicals
Neurotransmitter Agents
Pancreas
Mitochondria
Liver
Enzymes
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Manganese : Its Role in Disease and Health. / Erikson, Keith M.; Aschner, Michael.

In: Metal ions in life sciences, Vol. 19, 14.01.2019.

Research output: Contribution to journalArticle

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