Manganese-induced dopaminergic neurodegeneration: Insights into mechanisms and genetics shared with parkinson's disease

Alexandre Benedetto, Catherine Au, Michael Aschner

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

A study was conducted to survey the similarities between Parkinson's Disease (PD) and manganese (Mn) neurotoxicity. Investigations focused on the cellular pathway common to both disorders and identified PD genes. Some relevant information was provided about the etiology of PD and Mn toxicity gathered from various model mechanisms. The study also investigated the conservation of PD genes across different species. It was found that the brain areas most susceptible to Mn injury were highly sensitive to oxidative stress. It was found that Mn accumulated in the substantia nigra (SN), globus pallidus (GP), and striatum (STR) where it interfered with ATP synthesis. The accumulation of Mn in these brain regions corresponded to highly dense expression of the divalent metal transporter 1 (DMT1), which was found to be responsible for dietary and olfactory Mn uptake.

Original languageEnglish (US)
Pages (from-to)4862-4884
Number of pages23
JournalChemical Reviews
Volume109
Issue number10
DOIs
StatePublished - Oct 14 2009
Externally publishedYes

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Manganese
Brain
Genes
Oxidative stress
Toxicity
Genetics
Conservation
Adenosine Triphosphate

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Manganese-induced dopaminergic neurodegeneration : Insights into mechanisms and genetics shared with parkinson's disease. / Benedetto, Alexandre; Au, Catherine; Aschner, Michael.

In: Chemical Reviews, Vol. 109, No. 10, 14.10.2009, p. 4862-4884.

Research output: Contribution to journalArticle

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