Manganese-induced dopaminergic neurodegeneration: Insights into mechanisms and genetics shared with parkinson's disease

Alexandre Benedetto; Catherine Au; Michael Aschner

doi:10.1021/cr800536y

Manganese-induced dopaminergic neurodegeneration: Insights into mechanisms and genetics shared with parkinson's disease

Alexandre Benedetto, Catherine Au, Michael Aschner

Research output: Contribution to journal › Article › peer-review

104 Scopus citations

Abstract

A study was conducted to survey the similarities between Parkinson's Disease (PD) and manganese (Mn) neurotoxicity. Investigations focused on the cellular pathway common to both disorders and identified PD genes. Some relevant information was provided about the etiology of PD and Mn toxicity gathered from various model mechanisms. The study also investigated the conservation of PD genes across different species. It was found that the brain areas most susceptible to Mn injury were highly sensitive to oxidative stress. It was found that Mn accumulated in the substantia nigra (SN), globus pallidus (GP), and striatum (STR) where it interfered with ATP synthesis. The accumulation of Mn in these brain regions corresponded to highly dense expression of the divalent metal transporter 1 (DMT1), which was found to be responsible for dietary and olfactory Mn uptake.

Original language	English (US)
Pages (from-to)	4862-4884
Number of pages	23
Journal	Chemical Reviews
Volume	109
Issue number	10
DOIs	https://doi.org/10.1021/cr800536y
State	Published - Oct 14 2009
Externally published	Yes

ASJC Scopus subject areas

General Chemistry

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title = "Manganese-induced dopaminergic neurodegeneration: Insights into mechanisms and genetics shared with parkinson's disease",

abstract = "A study was conducted to survey the similarities between Parkinson's Disease (PD) and manganese (Mn) neurotoxicity. Investigations focused on the cellular pathway common to both disorders and identified PD genes. Some relevant information was provided about the etiology of PD and Mn toxicity gathered from various model mechanisms. The study also investigated the conservation of PD genes across different species. It was found that the brain areas most susceptible to Mn injury were highly sensitive to oxidative stress. It was found that Mn accumulated in the substantia nigra (SN), globus pallidus (GP), and striatum (STR) where it interfered with ATP synthesis. The accumulation of Mn in these brain regions corresponded to highly dense expression of the divalent metal transporter 1 (DMT1), which was found to be responsible for dietary and olfactory Mn uptake.",

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AU - Aschner, Michael

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AB - A study was conducted to survey the similarities between Parkinson's Disease (PD) and manganese (Mn) neurotoxicity. Investigations focused on the cellular pathway common to both disorders and identified PD genes. Some relevant information was provided about the etiology of PD and Mn toxicity gathered from various model mechanisms. The study also investigated the conservation of PD genes across different species. It was found that the brain areas most susceptible to Mn injury were highly sensitive to oxidative stress. It was found that Mn accumulated in the substantia nigra (SN), globus pallidus (GP), and striatum (STR) where it interfered with ATP synthesis. The accumulation of Mn in these brain regions corresponded to highly dense expression of the divalent metal transporter 1 (DMT1), which was found to be responsible for dietary and olfactory Mn uptake.

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Manganese-induced dopaminergic neurodegeneration: Insights into mechanisms and genetics shared with parkinson's disease

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