Manganese homeostasis in the nervous system

Pan Chen, Sudipta Chakraborty, Somshuvra Mukhopadhyay, Eunsook Lee, Monica M.B. Paoliello, Aaron B. Bowman, Michael Aschner

Research output: Contribution to journalReview article

116 Scopus citations

Abstract

Manganese (Mn) is an essential heavy metal that is naturally found in the environment. Daily intake through dietary sources provides the necessary amount required for several key physiological processes, including antioxidant defense, energy metabolism, immune function and others. However, overexposure from environmental sources can result in a condition known as manganism that features symptomatology similar to Parkinson's disease (PD). This disorder presents with debilitating motor and cognitive deficits that arise from a neurodegenerative process. In order to maintain a balance between its essentiality and neurotoxicity, several mechanisms exist to properly buffer cellular Mn levels. These include transporters involved in Mn uptake, and newly discovered Mn efflux mechanisms. This review will focus on current studies related to mechanisms underlying Mn import and export, primarily the Mn transporters, and their function and roles in Mn-induced neurotoxicity.

Original languageEnglish (US)
Pages (from-to)601-610
Number of pages10
JournalJournal of Neurochemistry
Volume134
Issue number4
DOIs
StatePublished - Aug 1 2015

Keywords

  • Parkinson's disease
  • manganese
  • transport

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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    Chen, P., Chakraborty, S., Mukhopadhyay, S., Lee, E., Paoliello, M. M. B., Bowman, A. B., & Aschner, M. (2015). Manganese homeostasis in the nervous system. Journal of Neurochemistry, 134(4), 601-610. https://doi.org/10.1111/jnc.13170