Manganese homeostasis in the nervous system

Pan Chen, Sudipta Chakraborty, Somshuvra Mukhopadhyay, Eunsook Lee, Monica M B Paoliello, Aaron B. Bowman, Michael Aschner

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Manganese (Mn) is an essential heavy metal that is naturally found in the environment. Daily intake through dietary sources provides the necessary amount required for several key physiological processes, including antioxidant defense, energy metabolism, immune function and others. However, overexposure from environmental sources can result in a condition known as manganism that features symptomatology similar to Parkinson's disease (PD). This disorder presents with debilitating motor and cognitive deficits that arise from a neurodegenerative process. In order to maintain a balance between its essentiality and neurotoxicity, several mechanisms exist to properly buffer cellular Mn levels. These include transporters involved in Mn uptake, and newly discovered Mn efflux mechanisms. This review will focus on current studies related to mechanisms underlying Mn import and export, primarily the Mn transporters, and their function and roles in Mn-induced neurotoxicity.

Original languageEnglish (US)
Pages (from-to)601-610
Number of pages10
JournalJournal of Neurochemistry
Volume134
Issue number4
DOIs
StatePublished - Aug 1 2015

Fingerprint

Neurology
Manganese
Nervous System
Homeostasis
Physiological Phenomena
Heavy Metals
Energy Metabolism
Parkinson Disease
Buffers
Antioxidants

Keywords

  • manganese
  • Parkinson's disease
  • transport

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Chen, P., Chakraborty, S., Mukhopadhyay, S., Lee, E., Paoliello, M. M. B., Bowman, A. B., & Aschner, M. (2015). Manganese homeostasis in the nervous system. Journal of Neurochemistry, 134(4), 601-610. https://doi.org/10.1111/jnc.13170

Manganese homeostasis in the nervous system. / Chen, Pan; Chakraborty, Sudipta; Mukhopadhyay, Somshuvra; Lee, Eunsook; Paoliello, Monica M B; Bowman, Aaron B.; Aschner, Michael.

In: Journal of Neurochemistry, Vol. 134, No. 4, 01.08.2015, p. 601-610.

Research output: Contribution to journalArticle

Chen, P, Chakraborty, S, Mukhopadhyay, S, Lee, E, Paoliello, MMB, Bowman, AB & Aschner, M 2015, 'Manganese homeostasis in the nervous system', Journal of Neurochemistry, vol. 134, no. 4, pp. 601-610. https://doi.org/10.1111/jnc.13170
Chen P, Chakraborty S, Mukhopadhyay S, Lee E, Paoliello MMB, Bowman AB et al. Manganese homeostasis in the nervous system. Journal of Neurochemistry. 2015 Aug 1;134(4):601-610. https://doi.org/10.1111/jnc.13170
Chen, Pan ; Chakraborty, Sudipta ; Mukhopadhyay, Somshuvra ; Lee, Eunsook ; Paoliello, Monica M B ; Bowman, Aaron B. ; Aschner, Michael. / Manganese homeostasis in the nervous system. In: Journal of Neurochemistry. 2015 ; Vol. 134, No. 4. pp. 601-610.
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