Manganese and Neurodegeneration

Dinamene Marques dos Santos; Michael Aschner; Ana P. Marreilha dos Santos

doi:10.1016/B978-0-12-804562-6.00008-7

Manganese and Neurodegeneration

Dinamene Marques dos Santos, Michael Aschner, Ana P. Marreilha dos Santos

Molecular Pharmacology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Manganese (Mn; atomic no. 25, weight = 54.94 g/mol, density = 7.43 at 20°C) is a transitional metal (Group VIIa), isolated in 1774, by the Swedish chemist Scheele. Mn is the 12th most abundant element in the earth's crust, naturally present in rocks, soil, water, and food. Mn is known to be an essential trace element for animals since 1931, required for normal mammalian physiological processes, such as bone growth, development of cartilage and connective tissues, reproductive, neuronal, immune, and antioxidant functions. It can exist in 11 oxidation states from -3 to +7, being the normally encountered valences +2 (the most common form in nature), +4 (in dioxide Mn) and +7 (in permanganate ion).

Original language	English (US)
Title of host publication	Biometals in Neurodegenerative Diseases
Subtitle of host publication	Mechanisms and Therapeutics
Publisher	Elsevier Inc.
Pages	117-151
Number of pages	35
ISBN (Electronic)	9780128045633
ISBN (Print)	9780128045626
DOIs	https://doi.org/10.1016/B978-0-12-804562-6.00008-7
Publication status	Published - Apr 28 2017

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Keywords

Biokinetics
Homeostatic control
Manganese
Metabolic functions
Neurodegeneration

ASJC Scopus subject areas

Medicine(all)
Neuroscience(all)

Cite this

Marques dos Santos, D., Aschner, M., & Marreilha dos Santos, A. P. (2017). Manganese and Neurodegeneration. In Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics (pp. 117-151). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-804562-6.00008-7

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Access to Document

10.1016/B978-0-12-804562-6.00008-7