Abstract
Manganese (Mn; atomic no. 25, weight = 54.94 g/mol, density = 7.43 at 20°C) is a transitional metal (Group VIIa), isolated in 1774, by the Swedish chemist Scheele. Mn is the 12th most abundant element in the earth's crust, naturally present in rocks, soil, water, and food. Mn is known to be an essential trace element for animals since 1931, required for normal mammalian physiological processes, such as bone growth, development of cartilage and connective tissues, reproductive, neuronal, immune, and antioxidant functions. It can exist in 11 oxidation states from -3 to +7, being the normally encountered valences +2 (the most common form in nature), +4 (in dioxide Mn) and +7 (in permanganate ion).
| Original language | English (US) |
|---|---|
| Title of host publication | Biometals in Neurodegenerative Diseases |
| Subtitle of host publication | Mechanisms and Therapeutics |
| Publisher | Elsevier Inc. |
| Pages | 117-151 |
| Number of pages | 35 |
| ISBN (Electronic) | 9780128045633 |
| ISBN (Print) | 9780128045626 |
| DOIs | |
| State | Published - Apr 28 2017 |
Keywords
- Biokinetics
- Homeostatic control
- Manganese
- Metabolic functions
- Neurodegeneration
ASJC Scopus subject areas
- Medicine(all)
- Neuroscience(all)
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Cite this
Marques dos Santos, D., Aschner, M., & Marreilha dos Santos, A. P. (2017). Manganese and Neurodegeneration. In Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics (pp. 117-151). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-804562-6.00008-7