Manganese and aging

Nancy L. Parmalee, Michael Aschner

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Manganese (Mn) is an essential metal that is required as a cofactor for many enzymes and is necessary for optimal biological function. Mn is abundant in the earth's crust and is present in soil and well water. Mn is also found in industrial settings, including mining, welding, and battery manufacture. Mn is also present in infant formula, parenteral nutrition, as well as pesticides and gasoline additives. A sufficient amount of Mn is obtained from most diets, and Mn deficiency is exceedingly rare. Excessive exposure to Mn in high doses can result in a condition known as manganism that results in psychological and emotional disturbances and motor symptoms that are reminiscent of Parkinson's disease, including gait disturbance, tremor, rigidity, and bradykinesia. Treatment for manganism is to remove the patient from Mn exposure, though symptoms are generally irreversible. The effects of exposure to Mn at lower doses are less clear. Little work has been done to evaluate the effects of chronic exposure to subclinical levels of Mn, especially in regard to lifelong exposures and the effects on the aging process. Mn is known to have effects on some of the same mechanistic processes that are altered in aging. This review will describe the general effects of Mn exposure and will focus on how Mn may be related to some of the mechanism of aging: neurogenesis, oxidative stress, and microglial activation and inflammation.

Original languageEnglish (US)
Pages (from-to)262-268
Number of pages7
JournalNeuroToxicology
Volume56
DOIs
StatePublished - Sep 1 2016

Fingerprint

Manganese
Aging of materials
Nutrition
Welding
Gasoline
Hypokinesia
Infant Formula
Affective Symptoms
Oxidative stress
Coenzymes
Neurogenesis
Parenteral Nutrition
Tremor
Gait
Pesticides
Rigidity
Parkinson Disease
Oxidative Stress
Soil
Metals

Keywords

  • Manganese
  • Manganism
  • Microglia
  • Neurodegeneration
  • Neurogenesis
  • Oxidative stress

ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology

Cite this

Manganese and aging. / Parmalee, Nancy L.; Aschner, Michael.

In: NeuroToxicology, Vol. 56, 01.09.2016, p. 262-268.

Research output: Contribution to journalArticle

Parmalee, Nancy L. ; Aschner, Michael. / Manganese and aging. In: NeuroToxicology. 2016 ; Vol. 56. pp. 262-268.
@article{5b66dd4c4b314cc7851fad04602d37e9,
title = "Manganese and aging",
abstract = "Manganese (Mn) is an essential metal that is required as a cofactor for many enzymes and is necessary for optimal biological function. Mn is abundant in the earth's crust and is present in soil and well water. Mn is also found in industrial settings, including mining, welding, and battery manufacture. Mn is also present in infant formula, parenteral nutrition, as well as pesticides and gasoline additives. A sufficient amount of Mn is obtained from most diets, and Mn deficiency is exceedingly rare. Excessive exposure to Mn in high doses can result in a condition known as manganism that results in psychological and emotional disturbances and motor symptoms that are reminiscent of Parkinson's disease, including gait disturbance, tremor, rigidity, and bradykinesia. Treatment for manganism is to remove the patient from Mn exposure, though symptoms are generally irreversible. The effects of exposure to Mn at lower doses are less clear. Little work has been done to evaluate the effects of chronic exposure to subclinical levels of Mn, especially in regard to lifelong exposures and the effects on the aging process. Mn is known to have effects on some of the same mechanistic processes that are altered in aging. This review will describe the general effects of Mn exposure and will focus on how Mn may be related to some of the mechanism of aging: neurogenesis, oxidative stress, and microglial activation and inflammation.",
keywords = "Manganese, Manganism, Microglia, Neurodegeneration, Neurogenesis, Oxidative stress",
author = "Parmalee, {Nancy L.} and Michael Aschner",
year = "2016",
month = "9",
day = "1",
doi = "10.1016/j.neuro.2016.06.006",
language = "English (US)",
volume = "56",
pages = "262--268",
journal = "NeuroToxicology",
issn = "0161-813X",
publisher = "Elsevier",

}

TY - JOUR

T1 - Manganese and aging

AU - Parmalee, Nancy L.

AU - Aschner, Michael

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Manganese (Mn) is an essential metal that is required as a cofactor for many enzymes and is necessary for optimal biological function. Mn is abundant in the earth's crust and is present in soil and well water. Mn is also found in industrial settings, including mining, welding, and battery manufacture. Mn is also present in infant formula, parenteral nutrition, as well as pesticides and gasoline additives. A sufficient amount of Mn is obtained from most diets, and Mn deficiency is exceedingly rare. Excessive exposure to Mn in high doses can result in a condition known as manganism that results in psychological and emotional disturbances and motor symptoms that are reminiscent of Parkinson's disease, including gait disturbance, tremor, rigidity, and bradykinesia. Treatment for manganism is to remove the patient from Mn exposure, though symptoms are generally irreversible. The effects of exposure to Mn at lower doses are less clear. Little work has been done to evaluate the effects of chronic exposure to subclinical levels of Mn, especially in regard to lifelong exposures and the effects on the aging process. Mn is known to have effects on some of the same mechanistic processes that are altered in aging. This review will describe the general effects of Mn exposure and will focus on how Mn may be related to some of the mechanism of aging: neurogenesis, oxidative stress, and microglial activation and inflammation.

AB - Manganese (Mn) is an essential metal that is required as a cofactor for many enzymes and is necessary for optimal biological function. Mn is abundant in the earth's crust and is present in soil and well water. Mn is also found in industrial settings, including mining, welding, and battery manufacture. Mn is also present in infant formula, parenteral nutrition, as well as pesticides and gasoline additives. A sufficient amount of Mn is obtained from most diets, and Mn deficiency is exceedingly rare. Excessive exposure to Mn in high doses can result in a condition known as manganism that results in psychological and emotional disturbances and motor symptoms that are reminiscent of Parkinson's disease, including gait disturbance, tremor, rigidity, and bradykinesia. Treatment for manganism is to remove the patient from Mn exposure, though symptoms are generally irreversible. The effects of exposure to Mn at lower doses are less clear. Little work has been done to evaluate the effects of chronic exposure to subclinical levels of Mn, especially in regard to lifelong exposures and the effects on the aging process. Mn is known to have effects on some of the same mechanistic processes that are altered in aging. This review will describe the general effects of Mn exposure and will focus on how Mn may be related to some of the mechanism of aging: neurogenesis, oxidative stress, and microglial activation and inflammation.

KW - Manganese

KW - Manganism

KW - Microglia

KW - Neurodegeneration

KW - Neurogenesis

KW - Oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=84991497603&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84991497603&partnerID=8YFLogxK

U2 - 10.1016/j.neuro.2016.06.006

DO - 10.1016/j.neuro.2016.06.006

M3 - Article

C2 - 27293182

AN - SCOPUS:84991497603

VL - 56

SP - 262

EP - 268

JO - NeuroToxicology

JF - NeuroToxicology

SN - 0161-813X

ER -