Manganese

Dejan Milatovic, Ramesh C. Gupta, Zhaobao Yin, Snjezana Zaja-Milatovic, Michael Aschner

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

This chapter discusses Manganese (Mn), which is a naturally occurring trace metal commonly found in the environment. Mn exposure may start before birth from the maternal exposure through inhalation and ingestion of food items from environmental pollution. Although its accumulation is associated with reproductive effects, Mn is generally described as neurotoxicant selectively affecting the basal ganglia. Mn is essential for maintaining the proper functioning and regulation of many biochemical and cellular reactions, but is a common environmental contaminant, which can cause toxic effects in humans. Postnatal exposure can also be relevant due to a relatively high concentration of Mn in formulas and continued exposure during the childhood and adulthood from both environmental and occupational exposures. Mn accumulation is associated with reproductive and developmental effects; it also affects the neurosystem adversely. The major routes of intake for Mn in humans are via inhalation and ingestion. Mn toxicity is mostly associated with a neurological disorder referred to as manganism. Symptoms of manganism include irritability, aggressiveness, hallucinations, tremors, difficulty in walking and facial muscle spasm. Children exposed to high levels of Mn in drinking water may develop a variety of adverse developmental effects, particularly relevant to their behaviors and ability to learn and remember. Risk assessment qualitative and quantitative health effects information must be related to available exposure information. The chapter also throws some light on the treatment methods of Mn toxicity. © 2011

Original languageEnglish (US)
Title of host publicationReproductive and Developmental Toxicology
PublisherElsevier Inc.
Pages439-450
Number of pages12
ISBN (Print)9780123820327
DOIs
StatePublished - 2011
Externally publishedYes

Fingerprint

Manganese
Inhalation
Eating
Facial Muscles
Mobility Limitation
Maternal Exposure
Environmental Pollution
Aptitude
Poisons
Hallucinations
Environmental Exposure
Spasm
Tremor
Occupational Exposure
Basal Ganglia
Nervous System Diseases
Drinking Water
Metals
Parturition
Food

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Milatovic, D., Gupta, R. C., Yin, Z., Zaja-Milatovic, S., & Aschner, M. (2011). Manganese. In Reproductive and Developmental Toxicology (pp. 439-450). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-382032-7.10034-7

Manganese. / Milatovic, Dejan; Gupta, Ramesh C.; Yin, Zhaobao; Zaja-Milatovic, Snjezana; Aschner, Michael.

Reproductive and Developmental Toxicology. Elsevier Inc., 2011. p. 439-450.

Research output: Chapter in Book/Report/Conference proceedingChapter

Milatovic, D, Gupta, RC, Yin, Z, Zaja-Milatovic, S & Aschner, M 2011, Manganese. in Reproductive and Developmental Toxicology. Elsevier Inc., pp. 439-450. https://doi.org/10.1016/B978-0-12-382032-7.10034-7
Milatovic D, Gupta RC, Yin Z, Zaja-Milatovic S, Aschner M. Manganese. In Reproductive and Developmental Toxicology. Elsevier Inc. 2011. p. 439-450 https://doi.org/10.1016/B978-0-12-382032-7.10034-7
Milatovic, Dejan ; Gupta, Ramesh C. ; Yin, Zhaobao ; Zaja-Milatovic, Snjezana ; Aschner, Michael. / Manganese. Reproductive and Developmental Toxicology. Elsevier Inc., 2011. pp. 439-450
@inbook{4d29d3b2be0d4ec89c12c8daabd78b2a,
title = "Manganese",
abstract = "This chapter discusses Manganese (Mn), which is a naturally occurring trace metal commonly found in the environment. Mn exposure may start before birth from the maternal exposure through inhalation and ingestion of food items from environmental pollution. Although its accumulation is associated with reproductive effects, Mn is generally described as neurotoxicant selectively affecting the basal ganglia. Mn is essential for maintaining the proper functioning and regulation of many biochemical and cellular reactions, but is a common environmental contaminant, which can cause toxic effects in humans. Postnatal exposure can also be relevant due to a relatively high concentration of Mn in formulas and continued exposure during the childhood and adulthood from both environmental and occupational exposures. Mn accumulation is associated with reproductive and developmental effects; it also affects the neurosystem adversely. The major routes of intake for Mn in humans are via inhalation and ingestion. Mn toxicity is mostly associated with a neurological disorder referred to as manganism. Symptoms of manganism include irritability, aggressiveness, hallucinations, tremors, difficulty in walking and facial muscle spasm. Children exposed to high levels of Mn in drinking water may develop a variety of adverse developmental effects, particularly relevant to their behaviors and ability to learn and remember. Risk assessment qualitative and quantitative health effects information must be related to available exposure information. The chapter also throws some light on the treatment methods of Mn toxicity. {\circledC} 2011",
author = "Dejan Milatovic and Gupta, {Ramesh C.} and Zhaobao Yin and Snjezana Zaja-Milatovic and Michael Aschner",
year = "2011",
doi = "10.1016/B978-0-12-382032-7.10034-7",
language = "English (US)",
isbn = "9780123820327",
pages = "439--450",
booktitle = "Reproductive and Developmental Toxicology",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Manganese

AU - Milatovic, Dejan

AU - Gupta, Ramesh C.

AU - Yin, Zhaobao

AU - Zaja-Milatovic, Snjezana

AU - Aschner, Michael

PY - 2011

Y1 - 2011

N2 - This chapter discusses Manganese (Mn), which is a naturally occurring trace metal commonly found in the environment. Mn exposure may start before birth from the maternal exposure through inhalation and ingestion of food items from environmental pollution. Although its accumulation is associated with reproductive effects, Mn is generally described as neurotoxicant selectively affecting the basal ganglia. Mn is essential for maintaining the proper functioning and regulation of many biochemical and cellular reactions, but is a common environmental contaminant, which can cause toxic effects in humans. Postnatal exposure can also be relevant due to a relatively high concentration of Mn in formulas and continued exposure during the childhood and adulthood from both environmental and occupational exposures. Mn accumulation is associated with reproductive and developmental effects; it also affects the neurosystem adversely. The major routes of intake for Mn in humans are via inhalation and ingestion. Mn toxicity is mostly associated with a neurological disorder referred to as manganism. Symptoms of manganism include irritability, aggressiveness, hallucinations, tremors, difficulty in walking and facial muscle spasm. Children exposed to high levels of Mn in drinking water may develop a variety of adverse developmental effects, particularly relevant to their behaviors and ability to learn and remember. Risk assessment qualitative and quantitative health effects information must be related to available exposure information. The chapter also throws some light on the treatment methods of Mn toxicity. © 2011

AB - This chapter discusses Manganese (Mn), which is a naturally occurring trace metal commonly found in the environment. Mn exposure may start before birth from the maternal exposure through inhalation and ingestion of food items from environmental pollution. Although its accumulation is associated with reproductive effects, Mn is generally described as neurotoxicant selectively affecting the basal ganglia. Mn is essential for maintaining the proper functioning and regulation of many biochemical and cellular reactions, but is a common environmental contaminant, which can cause toxic effects in humans. Postnatal exposure can also be relevant due to a relatively high concentration of Mn in formulas and continued exposure during the childhood and adulthood from both environmental and occupational exposures. Mn accumulation is associated with reproductive and developmental effects; it also affects the neurosystem adversely. The major routes of intake for Mn in humans are via inhalation and ingestion. Mn toxicity is mostly associated with a neurological disorder referred to as manganism. Symptoms of manganism include irritability, aggressiveness, hallucinations, tremors, difficulty in walking and facial muscle spasm. Children exposed to high levels of Mn in drinking water may develop a variety of adverse developmental effects, particularly relevant to their behaviors and ability to learn and remember. Risk assessment qualitative and quantitative health effects information must be related to available exposure information. The chapter also throws some light on the treatment methods of Mn toxicity. © 2011

UR - http://www.scopus.com/inward/record.url?scp=84884419992&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884419992&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-382032-7.10034-7

DO - 10.1016/B978-0-12-382032-7.10034-7

M3 - Chapter

SN - 9780123820327

SP - 439

EP - 450

BT - Reproductive and Developmental Toxicology

PB - Elsevier Inc.

ER -