Managing incidentally diagnosed isolated factor VII deficiency perioperatively: A brief expert consensus report

Sujit Sheth, Gerald Soff, Beau Mitchell, David Green, Shipra Kaicker, Fernando Fireman, Oya Tugal, Ludovico Guarini, Patricia Giardina, Louis Aledort

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

While isolated factor VII (FVII) deficiency is being more frequently diagnosed owing to improved preoperative screening procedures, there is no specific guideline for perioperative management of such patients. To complicate the issue, FVII activity levels seem to correlate less well with the risk of hemorrhage than the patient's past and family bleeding history do. We have devised expert consensus recommendations for managing such patients perioperatively, taking into consideration the personal and family bleeding history, the FVII activity level and the inherent bleeding risk of the procedure itself. We hope that clinicians will find this a useful tool in the decision-making process, thereby limiting the use of recombinant factor VIIa to those who need it most, and preventing possible thrombotic complications in those without a strong indication for its use.

Original languageEnglish (US)
Pages (from-to)47-50
Number of pages4
JournalExpert Review of Hematology
Volume5
Issue number1
DOIs
StatePublished - Feb 2012
Externally publishedYes

Keywords

  • FVII deficiency
  • perioperative management algorithm
  • variable bleeding

ASJC Scopus subject areas

  • Hematology

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