Managing hypothyroidism

Lawrence E. Shapiro, Martin I. Surks

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The treatment of hypothyroidism with thyroid hormone-containing medications has entered its second century. The success of treatment for this common disorder stands out among therapies for chronic disease. Due to the slow metabolism and onset of action of thyroxine (T<inf>4</inf>), it is possible to reproduce physiologic serum levels of thyroid hormone and TSH by once daily oral administration of T<inf>4</inf>. Modern assays for serum TSH enable precise regulation of T<inf>4</inf> replacement so that subtle “undertreatment” or “overtreatment” can be prevented. The goals of therapy depend on age, coexisting diseases, and general health of the patient. The initial T<inf>4</inf> dose, its adjustment, and the frequency of follow-up evaluation are also affected by these variables. Adverse effects of overtreatment, such as worsening coronary artery disease or the accelerated loss of bone mineral, can be avoided by following simple management guidelines. Health status changes such as pregnancy, systemic disease, or new medications should prompt a review of the management plan.

Original languageEnglish (US)
Pages (from-to)343-347
Number of pages5
JournalEndocrinologist
Volume1
Issue number4
StatePublished - 1991

Fingerprint

Hypothyroidism
Thyroid Hormones
Therapeutics
Serum
Thyroxine
Health Status
Minerals
Oral Administration
Coronary Artery Disease
Chronic Disease
Guidelines
Bone and Bones
Pregnancy
Health
Medical Overuse

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Shapiro, L. E., & Surks, M. I. (1991). Managing hypothyroidism. Endocrinologist, 1(4), 343-347.

Managing hypothyroidism. / Shapiro, Lawrence E.; Surks, Martin I.

In: Endocrinologist, Vol. 1, No. 4, 1991, p. 343-347.

Research output: Contribution to journalArticle

Shapiro, LE & Surks, MI 1991, 'Managing hypothyroidism', Endocrinologist, vol. 1, no. 4, pp. 343-347.
Shapiro LE, Surks MI. Managing hypothyroidism. Endocrinologist. 1991;1(4):343-347.
Shapiro, Lawrence E. ; Surks, Martin I. / Managing hypothyroidism. In: Endocrinologist. 1991 ; Vol. 1, No. 4. pp. 343-347.
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