TY - JOUR
T1 - Management options and fertility-preserving therapy for premenopausal endometrial hyperplasia and early-stage endometrial cancer
AU - Gressel, Gregory M.
AU - Parkash, Vinita
AU - Pal, Lubna
N1 - Publisher Copyright:
© 2015 International Federation of Gynecology and Obstetrics.
PY - 2015
Y1 - 2015
N2 - Background Definitive management with hysterectomy could be appropriate for some patients with endometrial cancer and its precursor lesions, but poses challenges for those desiring future fertility. Objectives To review risk factors for endometrial hyperplasia/cancer among premenopausal women and discuss management options for fertility preservation. Search strategy A literature search through the PubMed, Ovid, and Cochrane databases was conducted using the terms "endometrial hyperplasia" and "endometrial cancer," cross-referenced with "fertility preservation." Selection criteria All articles published in English between January 1, 2000, and January 1, 2015, were considered if they were readily available online. Data collection and analysis Articles were analyzed and information was synthesized into a comprehensive review. Main results Chronic anovulation, obesity, polycystic ovarian syndrome, metabolic syndrome, insulin resistance, and type 2 diabetes mellitus must be appreciated as risk factors for endometrial pathology. Providers must exert vigilance in identifying patients at risk and in initiating pre-emptive strategies. Risk reduction with lifestyle modification, weight loss, and glycemic control can improve regression and overall health. Fertility outcomes for these patients are promising, especially with assisted reproductive technology. Conclusions Conservative management could be appropriate for carefully selected women with complex atypical endometrial hyperplasia or early-stage endometrial cancer who desire future fertility.
AB - Background Definitive management with hysterectomy could be appropriate for some patients with endometrial cancer and its precursor lesions, but poses challenges for those desiring future fertility. Objectives To review risk factors for endometrial hyperplasia/cancer among premenopausal women and discuss management options for fertility preservation. Search strategy A literature search through the PubMed, Ovid, and Cochrane databases was conducted using the terms "endometrial hyperplasia" and "endometrial cancer," cross-referenced with "fertility preservation." Selection criteria All articles published in English between January 1, 2000, and January 1, 2015, were considered if they were readily available online. Data collection and analysis Articles were analyzed and information was synthesized into a comprehensive review. Main results Chronic anovulation, obesity, polycystic ovarian syndrome, metabolic syndrome, insulin resistance, and type 2 diabetes mellitus must be appreciated as risk factors for endometrial pathology. Providers must exert vigilance in identifying patients at risk and in initiating pre-emptive strategies. Risk reduction with lifestyle modification, weight loss, and glycemic control can improve regression and overall health. Fertility outcomes for these patients are promising, especially with assisted reproductive technology. Conclusions Conservative management could be appropriate for carefully selected women with complex atypical endometrial hyperplasia or early-stage endometrial cancer who desire future fertility.
KW - Complex atypical endometrial hyperplasia
KW - Early-stage endometrial cancer
KW - Fertility preservation
KW - Progestin therapy
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U2 - 10.1016/j.ijgo.2015.06.031
DO - 10.1016/j.ijgo.2015.06.031
M3 - Review article
C2 - 26384790
AN - SCOPUS:84941780215
SN - 0020-7292
VL - 131
SP - 234
EP - 239
JO - International Journal of Gynecology and Obstetrics
JF - International Journal of Gynecology and Obstetrics
IS - 3
ER -