Management options and fertility-preserving therapy for premenopausal endometrial hyperplasia and early-stage endometrial cancer

Gregory M. Gressel, Vinita Parkash, Lubna Pal

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


Background Definitive management with hysterectomy could be appropriate for some patients with endometrial cancer and its precursor lesions, but poses challenges for those desiring future fertility. Objectives To review risk factors for endometrial hyperplasia/cancer among premenopausal women and discuss management options for fertility preservation. Search strategy A literature search through the PubMed, Ovid, and Cochrane databases was conducted using the terms "endometrial hyperplasia" and "endometrial cancer," cross-referenced with "fertility preservation." Selection criteria All articles published in English between January 1, 2000, and January 1, 2015, were considered if they were readily available online. Data collection and analysis Articles were analyzed and information was synthesized into a comprehensive review. Main results Chronic anovulation, obesity, polycystic ovarian syndrome, metabolic syndrome, insulin resistance, and type 2 diabetes mellitus must be appreciated as risk factors for endometrial pathology. Providers must exert vigilance in identifying patients at risk and in initiating pre-emptive strategies. Risk reduction with lifestyle modification, weight loss, and glycemic control can improve regression and overall health. Fertility outcomes for these patients are promising, especially with assisted reproductive technology. Conclusions Conservative management could be appropriate for carefully selected women with complex atypical endometrial hyperplasia or early-stage endometrial cancer who desire future fertility.

Original languageEnglish (US)
Pages (from-to)234-239
Number of pages6
JournalInternational Journal of Gynecology and Obstetrics
Issue number3
StatePublished - Jan 1 2015
Externally publishedYes


  • Complex atypical endometrial hyperplasia
  • Early-stage endometrial cancer
  • Fertility preservation
  • Progestin therapy

ASJC Scopus subject areas

  • Obstetrics and Gynecology


Dive into the research topics of 'Management options and fertility-preserving therapy for premenopausal endometrial hyperplasia and early-stage endometrial cancer'. Together they form a unique fingerprint.

Cite this