Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma: where are we?

Stuart E. Samuels, Avraham Eisbruch, Jonathan J. Beitler, June Corry, Carol R. Bradford, Nabil F. Saba, Michiel W M van Den Brekel, Robert Smee, Primož Strojan, Carlos Suárez, William M. Mendenhall, Robert P. Takes, Juan P. Rodrigo, Missak Haigentz, Alexander D. Rapidis, Alessandra Rinaldo, Alfio Ferlito

Research output: Contribution to journalArticle

13 Scopus citations


HPV-related (HPV+) oropharyngeal cancer (OPC) has a better prognosis compared to HPV unrelated (HPV−) OPC. This review summarizes and discusses several of the controversies regarding the management of HPV+ OPC, including the mechanism of its treatment sensitivity, modern surgical techniques, chemotherapy regimens, and treatment de-intensification protocols. We also discuss and reconsider potential adverse prognostic factors such as tumor EGFR expression, tumor hypoxia, and patient smoking history, as well as the significance of retropharyngeal adenopathy. Finally, we discuss elective nodal treatment of uninvolved lymph node stations. While this review does not exhaust all controversies related to the management of HPV+ OPC, it aims to highlight some of the most clinically relevant ones.

Original languageEnglish (US)
JournalEuropean Archives of Oto-Rhino-Laryngology
StateAccepted/In press - Oct 13 2015



  • Cetuximab
  • EGFR
  • HPV
  • Hypoxia
  • Oropharyngeal carcinoma
  • p16
  • Radiosensitivity
  • TORS
  • Treatment de-intensification

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Samuels, S. E., Eisbruch, A., Beitler, J. J., Corry, J., Bradford, C. R., Saba, N. F., van Den Brekel, M. W. M., Smee, R., Strojan, P., Suárez, C., Mendenhall, W. M., Takes, R. P., Rodrigo, J. P., Haigentz, M., Rapidis, A. D., Rinaldo, A., & Ferlito, A. (Accepted/In press). Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma: where are we? European Archives of Oto-Rhino-Laryngology.