Malignant ovarian germ cell tumor - Role of surgical staging and gonadal dysgenesis

Ken Yu Lin, Stefanie Bryant, David S. Miller, Siobhan M. Kehoe, Debra L. Richardson, Jayanthi S. Lea

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective To evaluate the effect of comprehensive surgical staging and gonadal dysgenesis on the outcomes of patients with malignant ovarian germ cell tumor. Methods We performed a retrospective review of patients with ovarian germ cell tumors who were treated at our institution between 1976 and 2012. Results Malignant ovarian germ cell tumors (MOGCTs) were identified in 50 females. The median age was 24 years (range 13 to 49). Of all MOGCT patients, 42% had dysgerminoma, 20% immature teratoma, 16% endodermal sinus tumor, and 22% mixed germ cell tumor. Univariate analyses revealed that the lack of surgical staging (p = 0.048) and endodermal sinus tumor (p = 0.0085) were associated with disease recurrence, while age at diagnosis, ethnicity, and stage of the disease were not. Multivariate analyses revealed that the lack of surgical staging (p = 0.029) and endodermal sinus tumor (p = 0.016) were independently associated with disease recurrence. In addition, 7 patients (14%) had 46 XY karyotype, including 6 with pure dysgerminoma and 1 with mixed germ cell tumor. Five had Swyer syndrome and 2 had complete androgen insensitivity syndrome. Concurrent gonadoblastoma was found in 5 of the patients. No difference was found in the mean age at presentation, stage distribution, or recurrence rate for MOGCT patients with or without XY phenotype. Conclusions Comprehensive surgical staging was associated with a lower rate of recurrence. Fourteen percent of phenotypic females with MOGCT and 29% of those with dysgerminoma had XY karyotype. The clinical outcome of these patients is similar to that of MOGCT patients with XX karyotype.

Original languageEnglish (US)
Pages (from-to)84-89
Number of pages6
JournalGynecologic Oncology
Volume134
Issue number1
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Gonadal Dysgenesis
Germ Cell and Embryonal Neoplasms
Dysgerminoma
Endodermal Sinus Tumor
Karyotype
Recurrence
46,XY Gonadal Dysgenesis
Gonadoblastoma
Androgen-Insensitivity Syndrome
Teratoma
Multivariate Analysis
Phenotype

Keywords

  • Malignant germ cell tumors
  • Surgical staging
  • XY karyotype

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

Cite this

Malignant ovarian germ cell tumor - Role of surgical staging and gonadal dysgenesis. / Lin, Ken Yu; Bryant, Stefanie; Miller, David S.; Kehoe, Siobhan M.; Richardson, Debra L.; Lea, Jayanthi S.

In: Gynecologic Oncology, Vol. 134, No. 1, 01.01.2014, p. 84-89.

Research output: Contribution to journalArticle

Lin, Ken Yu ; Bryant, Stefanie ; Miller, David S. ; Kehoe, Siobhan M. ; Richardson, Debra L. ; Lea, Jayanthi S. / Malignant ovarian germ cell tumor - Role of surgical staging and gonadal dysgenesis. In: Gynecologic Oncology. 2014 ; Vol. 134, No. 1. pp. 84-89.
@article{f4a5eadc251340c28965c4eb0239e282,
title = "Malignant ovarian germ cell tumor - Role of surgical staging and gonadal dysgenesis",
abstract = "Objective To evaluate the effect of comprehensive surgical staging and gonadal dysgenesis on the outcomes of patients with malignant ovarian germ cell tumor. Methods We performed a retrospective review of patients with ovarian germ cell tumors who were treated at our institution between 1976 and 2012. Results Malignant ovarian germ cell tumors (MOGCTs) were identified in 50 females. The median age was 24 years (range 13 to 49). Of all MOGCT patients, 42{\%} had dysgerminoma, 20{\%} immature teratoma, 16{\%} endodermal sinus tumor, and 22{\%} mixed germ cell tumor. Univariate analyses revealed that the lack of surgical staging (p = 0.048) and endodermal sinus tumor (p = 0.0085) were associated with disease recurrence, while age at diagnosis, ethnicity, and stage of the disease were not. Multivariate analyses revealed that the lack of surgical staging (p = 0.029) and endodermal sinus tumor (p = 0.016) were independently associated with disease recurrence. In addition, 7 patients (14{\%}) had 46 XY karyotype, including 6 with pure dysgerminoma and 1 with mixed germ cell tumor. Five had Swyer syndrome and 2 had complete androgen insensitivity syndrome. Concurrent gonadoblastoma was found in 5 of the patients. No difference was found in the mean age at presentation, stage distribution, or recurrence rate for MOGCT patients with or without XY phenotype. Conclusions Comprehensive surgical staging was associated with a lower rate of recurrence. Fourteen percent of phenotypic females with MOGCT and 29{\%} of those with dysgerminoma had XY karyotype. The clinical outcome of these patients is similar to that of MOGCT patients with XX karyotype.",
keywords = "Malignant germ cell tumors, Surgical staging, XY karyotype",
author = "Lin, {Ken Yu} and Stefanie Bryant and Miller, {David S.} and Kehoe, {Siobhan M.} and Richardson, {Debra L.} and Lea, {Jayanthi S.}",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.ygyno.2014.05.003",
language = "English (US)",
volume = "134",
pages = "84--89",
journal = "Gynecologic Oncology",
issn = "0090-8258",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Malignant ovarian germ cell tumor - Role of surgical staging and gonadal dysgenesis

AU - Lin, Ken Yu

AU - Bryant, Stefanie

AU - Miller, David S.

AU - Kehoe, Siobhan M.

AU - Richardson, Debra L.

AU - Lea, Jayanthi S.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Objective To evaluate the effect of comprehensive surgical staging and gonadal dysgenesis on the outcomes of patients with malignant ovarian germ cell tumor. Methods We performed a retrospective review of patients with ovarian germ cell tumors who were treated at our institution between 1976 and 2012. Results Malignant ovarian germ cell tumors (MOGCTs) were identified in 50 females. The median age was 24 years (range 13 to 49). Of all MOGCT patients, 42% had dysgerminoma, 20% immature teratoma, 16% endodermal sinus tumor, and 22% mixed germ cell tumor. Univariate analyses revealed that the lack of surgical staging (p = 0.048) and endodermal sinus tumor (p = 0.0085) were associated with disease recurrence, while age at diagnosis, ethnicity, and stage of the disease were not. Multivariate analyses revealed that the lack of surgical staging (p = 0.029) and endodermal sinus tumor (p = 0.016) were independently associated with disease recurrence. In addition, 7 patients (14%) had 46 XY karyotype, including 6 with pure dysgerminoma and 1 with mixed germ cell tumor. Five had Swyer syndrome and 2 had complete androgen insensitivity syndrome. Concurrent gonadoblastoma was found in 5 of the patients. No difference was found in the mean age at presentation, stage distribution, or recurrence rate for MOGCT patients with or without XY phenotype. Conclusions Comprehensive surgical staging was associated with a lower rate of recurrence. Fourteen percent of phenotypic females with MOGCT and 29% of those with dysgerminoma had XY karyotype. The clinical outcome of these patients is similar to that of MOGCT patients with XX karyotype.

AB - Objective To evaluate the effect of comprehensive surgical staging and gonadal dysgenesis on the outcomes of patients with malignant ovarian germ cell tumor. Methods We performed a retrospective review of patients with ovarian germ cell tumors who were treated at our institution between 1976 and 2012. Results Malignant ovarian germ cell tumors (MOGCTs) were identified in 50 females. The median age was 24 years (range 13 to 49). Of all MOGCT patients, 42% had dysgerminoma, 20% immature teratoma, 16% endodermal sinus tumor, and 22% mixed germ cell tumor. Univariate analyses revealed that the lack of surgical staging (p = 0.048) and endodermal sinus tumor (p = 0.0085) were associated with disease recurrence, while age at diagnosis, ethnicity, and stage of the disease were not. Multivariate analyses revealed that the lack of surgical staging (p = 0.029) and endodermal sinus tumor (p = 0.016) were independently associated with disease recurrence. In addition, 7 patients (14%) had 46 XY karyotype, including 6 with pure dysgerminoma and 1 with mixed germ cell tumor. Five had Swyer syndrome and 2 had complete androgen insensitivity syndrome. Concurrent gonadoblastoma was found in 5 of the patients. No difference was found in the mean age at presentation, stage distribution, or recurrence rate for MOGCT patients with or without XY phenotype. Conclusions Comprehensive surgical staging was associated with a lower rate of recurrence. Fourteen percent of phenotypic females with MOGCT and 29% of those with dysgerminoma had XY karyotype. The clinical outcome of these patients is similar to that of MOGCT patients with XX karyotype.

KW - Malignant germ cell tumors

KW - Surgical staging

KW - XY karyotype

UR - http://www.scopus.com/inward/record.url?scp=84903145408&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903145408&partnerID=8YFLogxK

U2 - 10.1016/j.ygyno.2014.05.003

DO - 10.1016/j.ygyno.2014.05.003

M3 - Article

VL - 134

SP - 84

EP - 89

JO - Gynecologic Oncology

JF - Gynecologic Oncology

SN - 0090-8258

IS - 1

ER -