Malfolded protein structure and proteostasis in lung diseases

William E. Balch, Jacob I. Sznajder, Scott Budinger, Daniel Finley, Aaron D. Laposky, Ana Maria Cuervo, Ivor J. Benjamin, Esther Barreiro, Richard I. Morimoto, Lisa Postow, Allan M. Weissman, Dorothy Gail, Susan Banks-Schlegel, Thomas Croxton, Weiniu Gan

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Recent discoveries indicate that disorders of protein folding and degradation play a particularly important role in the development of lung diseases and their associated complications. The overarching purpose of the National Heart, Lung, and Blood Institute workshop on "Malformed Protein Structure and Proteostasis in Lung Diseases" was to identify mechanistic and clinical research opportunities indicated by these recent discoveries in proteostasis science that will advance our molecular understanding of lung pathobiology and facilitate the development of new diagnostic and therapeutic strategies for the prevention and treatment of lung disease. The workshop's discussion focused on identifying gaps in scientific knowledge with respect to proteostasis and lung disease, discussing new research advances and opportunities in protein folding science, and highlighting novel technologies with potential therapeutic applications for diagnosis and treatment.

Original languageEnglish (US)
Pages (from-to)96-103
Number of pages8
JournalAmerican journal of respiratory and critical care medicine
Volume189
Issue number1
StatePublished - Jan 1 2014

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Keywords

  • Post-translational processing
  • Protein misfolding
  • Proteosome
  • Pulmonary health
  • Ubiquitination

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Balch, W. E., Sznajder, J. I., Budinger, S., Finley, D., Laposky, A. D., Cuervo, A. M., Benjamin, I. J., Barreiro, E., Morimoto, R. I., Postow, L., Weissman, A. M., Gail, D., Banks-Schlegel, S., Croxton, T., & Gan, W. (2014). Malfolded protein structure and proteostasis in lung diseases. American journal of respiratory and critical care medicine, 189(1), 96-103.