Abstract
Recent discoveries indicate that disorders of protein folding and degradation play a particularly important role in the development of lung diseases and their associated complications. The overarching purpose of the National Heart, Lung, and Blood Institute workshop on "Malformed Protein Structure and Proteostasis in Lung Diseases" was to identify mechanistic and clinical research opportunities indicated by these recent discoveries in proteostasis science that will advance our molecular understanding of lung pathobiology and facilitate the development of new diagnostic and therapeutic strategies for the prevention and treatment of lung disease. The workshop's discussion focused on identifying gaps in scientific knowledge with respect to proteostasis and lung disease, discussing new research advances and opportunities in protein folding science, and highlighting novel technologies with potential therapeutic applications for diagnosis and treatment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 96-103 |
| Number of pages | 8 |
| Journal | American journal of respiratory and critical care medicine |
| Volume | 189 |
| Issue number | 1 |
| State | Published - Jan 1 2014 |
Keywords
- Post-translational processing
- Protein misfolding
- Proteosome
- Pulmonary health
- Ubiquitination
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Critical Care and Intensive Care Medicine