Male sexual dysfunction associated with antiretroviral therapy

Amy E. Colson; Marla J. Keller; Paul E. Sax; Parker T. Pettus; Richard Platt; Peter W. Choo

doi:10.1097/00042560-200205010-00004

Male sexual dysfunction associated with antiretroviral therapy

Amy E. Colson, Marla J. Keller, Paul E. Sax, Parker T. Pettus, Richard Platt, Peter W. Choo

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

To determine whether treatment with protease inhibitors (PIs) is associated with male sexual dysfunction, we conducted a retrospective, cohort study of 254 adult male PI recipients who received care from the staff-model division of a large managed care organization in New England between 1993 and 1998. After a median of 5.0 years of observation, 80 incident cases of sexual dysfunction were observed. Relative to unexposed individuals, the rate of sexual dysfunction adjusted for confounding was most elevated with use of ritonavir (hazard ratio [HR], 2.83; 95% confidence interval [CI], 1.34-5.97; p = .006) followed by indinavir (HR, 1.69; 95% CI, 0.84-3.37; p = .14), nelfinavir (HR, 1.53; 95% CI, 0.66-3.54; p = .32) and saquinavir (HR, 1.25; 95% CI, 0.53-2.96; p = .60). We conclude that Pis, especially ritonavir, appear to increase the risk of sexual dysfunction.

Original language	English (US)
Pages (from-to)	27-32
Number of pages	6
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	30
Issue number	1
DOIs	https://doi.org/10.1097/00042560-200205010-00004
State	Published - May 1 2002
Externally published	Yes

Keywords

Adverse drug effects
Antiretroviral therapy
Protease inhibitors
Sexual dysfunction Pharmacoepidemiology

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/00042560-200205010-00004

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title = "Male sexual dysfunction associated with antiretroviral therapy",

abstract = "To determine whether treatment with protease inhibitors (PIs) is associated with male sexual dysfunction, we conducted a retrospective, cohort study of 254 adult male PI recipients who received care from the staff-model division of a large managed care organization in New England between 1993 and 1998. After a median of 5.0 years of observation, 80 incident cases of sexual dysfunction were observed. Relative to unexposed individuals, the rate of sexual dysfunction adjusted for confounding was most elevated with use of ritonavir (hazard ratio [HR], 2.83; 95% confidence interval [CI], 1.34-5.97; p = .006) followed by indinavir (HR, 1.69; 95% CI, 0.84-3.37; p = .14), nelfinavir (HR, 1.53; 95% CI, 0.66-3.54; p = .32) and saquinavir (HR, 1.25; 95% CI, 0.53-2.96; p = .60). We conclude that Pis, especially ritonavir, appear to increase the risk of sexual dysfunction.",

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AU - Colson, Amy E.

AU - Keller, Marla J.

AU - Sax, Paul E.

AU - Pettus, Parker T.

AU - Platt, Richard

AU - Choo, Peter W.

PY - 2002/5/1

Y1 - 2002/5/1

N2 - To determine whether treatment with protease inhibitors (PIs) is associated with male sexual dysfunction, we conducted a retrospective, cohort study of 254 adult male PI recipients who received care from the staff-model division of a large managed care organization in New England between 1993 and 1998. After a median of 5.0 years of observation, 80 incident cases of sexual dysfunction were observed. Relative to unexposed individuals, the rate of sexual dysfunction adjusted for confounding was most elevated with use of ritonavir (hazard ratio [HR], 2.83; 95% confidence interval [CI], 1.34-5.97; p = .006) followed by indinavir (HR, 1.69; 95% CI, 0.84-3.37; p = .14), nelfinavir (HR, 1.53; 95% CI, 0.66-3.54; p = .32) and saquinavir (HR, 1.25; 95% CI, 0.53-2.96; p = .60). We conclude that Pis, especially ritonavir, appear to increase the risk of sexual dysfunction.

AB - To determine whether treatment with protease inhibitors (PIs) is associated with male sexual dysfunction, we conducted a retrospective, cohort study of 254 adult male PI recipients who received care from the staff-model division of a large managed care organization in New England between 1993 and 1998. After a median of 5.0 years of observation, 80 incident cases of sexual dysfunction were observed. Relative to unexposed individuals, the rate of sexual dysfunction adjusted for confounding was most elevated with use of ritonavir (hazard ratio [HR], 2.83; 95% confidence interval [CI], 1.34-5.97; p = .006) followed by indinavir (HR, 1.69; 95% CI, 0.84-3.37; p = .14), nelfinavir (HR, 1.53; 95% CI, 0.66-3.54; p = .32) and saquinavir (HR, 1.25; 95% CI, 0.53-2.96; p = .60). We conclude that Pis, especially ritonavir, appear to increase the risk of sexual dysfunction.

KW - Adverse drug effects

KW - Antiretroviral therapy

KW - Protease inhibitors

KW - Sexual dysfunction Pharmacoepidemiology

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Male sexual dysfunction associated with antiretroviral therapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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