TY - JOUR
T1 - Malaria var gene expression
T2 - Keeping up with the neighbors
AU - Kim, Kami
N1 - Funding Information:
Work in K.K.'s laboratory is supported by NIH grants R01AI087625 and RC4AI092801.
PY - 2012/1/19
Y1 - 2012/1/19
N2 - Plasmodium falciparum PfEMP1 is a malaria virulence protein whose expression is epigenetically regulated. The parasite's ability to express exclusively only one of the sixty var genes that encode PfEMP1 is essential for disease pathogenesis. Two recent papers identify key molecular players in determining whether a var gene is active or silenced (Volz et al., 2012; Zhang et al., 2011).
AB - Plasmodium falciparum PfEMP1 is a malaria virulence protein whose expression is epigenetically regulated. The parasite's ability to express exclusively only one of the sixty var genes that encode PfEMP1 is essential for disease pathogenesis. Two recent papers identify key molecular players in determining whether a var gene is active or silenced (Volz et al., 2012; Zhang et al., 2011).
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U2 - 10.1016/j.chom.2012.01.002
DO - 10.1016/j.chom.2012.01.002
M3 - Short survey
C2 - 22264506
AN - SCOPUS:84862963374
SN - 1931-3128
VL - 11
SP - 1
EP - 2
JO - Cell Host and Microbe
JF - Cell Host and Microbe
IS - 1
ER -
