Malaria after international travel: A GeoSentinel analysis, 2003-2016

Kristina M. Angelo; Michael Libman; Eric Caumes; Davidson H. Hamer; Kevin C. Kain; Karin Leder; Martin P. Grobusch; Stefan H. Hagmann; Phyllis Kozarsky; David G. Lalloo; Poh Lian Lim; Calvin Patimeteeporn; Philippe Gautret; Silvia Odolini; François Chappuis; Douglas H. Esposito; Emilie Javelle; Francesco Castelli; Alberto Matteelli; Alice Perignon; Camilla Rothe; Christoph Rapp; Cecile Ficko; Eli Schwartz; Frank Von Sonnenburg; Watcharapong Piyaphanee; Udomsak Silachamroon; Andrea Boggild; Perry Van Genderen; Joe Torresi; Mogens Jensenius; Shuzo Kanagawa; Yasuyuki Kato; Cedric Yansouni; Anne McCarthy; Paul Kelly; Bram Goorhuis; Rogelio López-Vélez; Francesco Norman; Marc Mendelson; Peter Vincent; Effrossyni Gkrania-Klotsas; Ben Warne; Denis Malvy; Alexandre Duvignaud; Emanuel Bottieau; Joannes Clerinx; Christina Coyle; Hilmer Àsgeirsson; Hedvig Glans; Patricia Schlagenhauf; Rainer Weber; Frank Mockenhaupt; Gundel Harms-Zwingenberger; Nicholas Beeching; Jan Hajek; Wayne Ghesquiere; Henry Wu; Elizabeth Barnett; Natasha Hockberg; Yukiriro Yoshimura; Natsuo Tachikawa; John Cahill; George McKinley; William Stauffer; Pat Walker; Susan Kuhn; Lin Chen; Daniel Leung; Scott Benson; Carsten Schade Larsen; Christian Wejse; Vanessa Field; Carmelo Licitra; Alena Klochko; Noreen Hynes; Cecilia Perret Perez; Bradley Connor; Holly Murphy; Prativa Pandey; Jean Vincelette; Sapha Barkati; Simin Aysel Florescu; Corneliu Petru Popescu; Lucille Blumberg; Albie De Frey; Susan Anderson; Marc Shaw; Annemarie Hern; Israel Molina; Johnnie Yates; Hugo Siu; Luis Manuel Valdez; Jean Haulman; David Roesel; Phi Truong Hoang Phu; Sarah Borwein

doi:10.1186/s12936-017-1936-3

Malaria after international travel: A GeoSentinel analysis, 2003-2016

Kristina M. Angelo, Michael Libman, Eric Caumes, Davidson H. Hamer, Kevin C. Kain, Karin Leder, Martin P. Grobusch, Stefan H. Hagmann, Phyllis Kozarsky, David G. Lalloo, Poh Lian Lim, Calvin Patimeteeporn, Philippe Gautret, Silvia Odolini, François Chappuis, Douglas H. Esposito, Emilie Javelle, Francesco Castelli, Alberto Matteelli, Alice PerignonCamilla Rothe, Christoph Rapp, Cecile Ficko, Eli Schwartz, Frank Von Sonnenburg, Watcharapong Piyaphanee, Udomsak Silachamroon, Andrea Boggild, Perry Van Genderen, Joe Torresi, Mogens Jensenius, Shuzo Kanagawa, Yasuyuki Kato, Cedric Yansouni, Anne McCarthy, Paul Kelly, Bram Goorhuis, Rogelio López-Vélez, Francesco Norman, Marc Mendelson, Peter Vincent, Effrossyni Gkrania-Klotsas, Ben Warne, Denis Malvy, Alexandre Duvignaud, Emanuel Bottieau, Joannes Clerinx, Christina Coyle, Hilmer Àsgeirsson, Hedvig Glans, Patricia Schlagenhauf, Rainer Weber, Frank Mockenhaupt, Gundel Harms-Zwingenberger, Nicholas Beeching, Jan Hajek, Wayne Ghesquiere, Henry Wu, Elizabeth Barnett, Natasha Hockberg, Yukiriro Yoshimura, Natsuo Tachikawa, John Cahill, George McKinley, William Stauffer, Pat Walker, Susan Kuhn, Lin Chen, Daniel Leung, Scott Benson, Carsten Schade Larsen, Christian Wejse, Vanessa Field, Carmelo Licitra, Alena Klochko, Noreen Hynes, Cecilia Perret Perez, Bradley Connor, Holly Murphy, Prativa Pandey, Jean Vincelette, Sapha Barkati, Simin Aysel Florescu, Corneliu Petru Popescu, Lucille Blumberg, Albie De Frey, Susan Anderson, Marc Shaw, Annemarie Hern, Israel Molina, Johnnie Yates, Hugo Siu, Luis Manuel Valdez, Jean Haulman, David Roesel, Phi Truong Hoang Phu, Sarah Borwein

Medicine

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Background: More than 30,000 malaria cases are reported annually among international travellers. Despite improvements in malaria control, malaria continues to threaten travellers due to inaccurate perception of risk and sub-optimal pre-travel preparation. Methods: Records with a confirmed malaria diagnosis after travel from January 2003 to July 2016 were obtained from GeoSentinel, a global surveillance network of travel and tropical medicine providers that monitors travel-related morbidity. Records were excluded if exposure country was missing or unascertainable or if there was a concomitant acute diagnosis unrelated to malaria. Records were analyzed to describe the demographic and clinical characteristics of international travellers with malaria. Results: There were 5689 travellers included; 325 were children <18 years. More than half (53%) were visiting friends and relatives (VFRs). Most (83%) were exposed in sub-Saharan Africa. The median trip duration was 32 days (interquartile range 20-75); 53% did not have a pre-travel visit. More than half (62%) were hospitalized; children were hospitalized more frequently than adults (73 and 62%, respectively). Ninety-two per cent had a single Plasmodium species diagnosis, most frequently Plasmodium falciparum (4011; 76%). Travellers with P. falciparum were most frequently VFRs (60%). More than 40% of travellers with a trip duration ≤7 days had Plasmodium vivax. There were 444 (8%) travellers with severe malaria; 31 children had severe malaria. Twelve travellers died. Conclusion: Malaria remains a serious threat to international travellers. Efforts must focus on preventive strategies aimed on children and VFRs, and chemoprophylaxis access and preventive measure adherence should be emphasized.

Original language	English (US)
Article number	293
Journal	Malaria Journal
Volume	16
Issue number	1
DOIs	https://doi.org/10.1186/s12936-017-1936-3
State	Published - Jul 20 2017

Keywords

GeoSentinel
International travel
Malaria
Plasmodium spp

ASJC Scopus subject areas

Parasitology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s12936-017-1936-3

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Angelo, K. M., Libman, M., Caumes, E., Hamer, D. H., Kain, K. C., Leder, K., Grobusch, M. P., Hagmann, S. H., Kozarsky, P., Lalloo, D. G., Lim, P. L., Patimeteeporn, C., Gautret, P., Odolini, S., Chappuis, F., Esposito, D. H., Javelle, E., Castelli, F., Matteelli, A., ... Borwein, S. (2017). Malaria after international travel: A GeoSentinel analysis, 2003-2016. Malaria Journal, 16(1), Article 293. https://doi.org/10.1186/s12936-017-1936-3

Angelo, KM, Libman, M, Caumes, E, Hamer, DH, Kain, KC, Leder, K, Grobusch, MP, Hagmann, SH, Kozarsky, P, Lalloo, DG, Lim, PL, Patimeteeporn, C, Gautret, P, Odolini, S, Chappuis, F, Esposito, DH, Javelle, E, Castelli, F, Matteelli, A, Perignon, A, Rothe, C, Rapp, C, Ficko, C, Schwartz, E, Von Sonnenburg, F, Piyaphanee, W, Silachamroon, U, Boggild, A, Van Genderen, P, Torresi, J, Jensenius, M, Kanagawa, S, Kato, Y, Yansouni, C, McCarthy, A, Kelly, P, Goorhuis, B, López-Vélez, R, Norman, F, Mendelson, M, Vincent, P, Gkrania-Klotsas, E, Warne, B, Malvy, D, Duvignaud, A, Bottieau, E, Clerinx, J, Coyle, C, Àsgeirsson, H, Glans, H, Schlagenhauf, P, Weber, R, Mockenhaupt, F, Harms-Zwingenberger, G, Beeching, N, Hajek, J, Ghesquiere, W, Wu, H, Barnett, E, Hockberg, N, Yoshimura, Y, Tachikawa, N, Cahill, J, McKinley, G, Stauffer, W, Walker, P, Kuhn, S, Chen, L, Leung, D, Benson, S, Larsen, CS, Wejse, C, Field, V, Licitra, C, Klochko, A, Hynes, N, Perez, CP, Connor, B, Murphy, H, Pandey, P, Vincelette, J, Barkati, S, Florescu, SA, Popescu, CP, Blumberg, L, De Frey, A, Anderson, S, Shaw, M, Hern, A, Molina, I, Yates, J, Siu, H, Valdez, LM, Haulman, J, Roesel, D, Phu, PTH & Borwein, S 2017, 'Malaria after international travel: A GeoSentinel analysis, 2003-2016', Malaria Journal, vol. 16, no. 1, 293. https://doi.org/10.1186/s12936-017-1936-3

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title = "Malaria after international travel: A GeoSentinel analysis, 2003-2016",

abstract = "Background: More than 30,000 malaria cases are reported annually among international travellers. Despite improvements in malaria control, malaria continues to threaten travellers due to inaccurate perception of risk and sub-optimal pre-travel preparation. Methods: Records with a confirmed malaria diagnosis after travel from January 2003 to July 2016 were obtained from GeoSentinel, a global surveillance network of travel and tropical medicine providers that monitors travel-related morbidity. Records were excluded if exposure country was missing or unascertainable or if there was a concomitant acute diagnosis unrelated to malaria. Records were analyzed to describe the demographic and clinical characteristics of international travellers with malaria. Results: There were 5689 travellers included; 325 were children <18 years. More than half (53%) were visiting friends and relatives (VFRs). Most (83%) were exposed in sub-Saharan Africa. The median trip duration was 32 days (interquartile range 20-75); 53% did not have a pre-travel visit. More than half (62%) were hospitalized; children were hospitalized more frequently than adults (73 and 62%, respectively). Ninety-two per cent had a single Plasmodium species diagnosis, most frequently Plasmodium falciparum (4011; 76%). Travellers with P. falciparum were most frequently VFRs (60%). More than 40% of travellers with a trip duration ≤7 days had Plasmodium vivax. There were 444 (8%) travellers with severe malaria; 31 children had severe malaria. Twelve travellers died. Conclusion: Malaria remains a serious threat to international travellers. Efforts must focus on preventive strategies aimed on children and VFRs, and chemoprophylaxis access and preventive measure adherence should be emphasized.",

keywords = "GeoSentinel, International travel, Malaria, Plasmodium spp",

author = "Angelo, {Kristina M.} and Michael Libman and Eric Caumes and Hamer, {Davidson H.} and Kain, {Kevin C.} and Karin Leder and Grobusch, {Martin P.} and Hagmann, {Stefan H.} and Phyllis Kozarsky and Lalloo, {David G.} and Lim, {Poh Lian} and Calvin Patimeteeporn and Philippe Gautret and Silvia Odolini and Fran{\c c}ois Chappuis and Esposito, {Douglas H.} and Emilie Javelle and Francesco Castelli and Alberto Matteelli and Alice Perignon and Camilla Rothe and Christoph Rapp and Cecile Ficko and Eli Schwartz and {Von Sonnenburg}, Frank and Watcharapong Piyaphanee and Udomsak Silachamroon and Andrea Boggild and {Van Genderen}, Perry and Joe Torresi and Mogens Jensenius and Shuzo Kanagawa and Yasuyuki Kato and Cedric Yansouni and Anne McCarthy and Paul Kelly and Bram Goorhuis and Rogelio L{\'o}pez-V{\'e}lez and Francesco Norman and Marc Mendelson and Peter Vincent and Effrossyni Gkrania-Klotsas and Ben Warne and Denis Malvy and Alexandre Duvignaud and Emanuel Bottieau and Joannes Clerinx and Christina Coyle and Hilmer {\`A}sgeirsson and Hedvig Glans and Patricia Schlagenhauf and Rainer Weber and Frank Mockenhaupt and Gundel Harms-Zwingenberger and Nicholas Beeching and Jan Hajek and Wayne Ghesquiere and Henry Wu and Elizabeth Barnett and Natasha Hockberg and Yukiriro Yoshimura and Natsuo Tachikawa and John Cahill and George McKinley and William Stauffer and Pat Walker and Susan Kuhn and Lin Chen and Daniel Leung and Scott Benson and Larsen, {Carsten Schade} and Christian Wejse and Vanessa Field and Carmelo Licitra and Alena Klochko and Noreen Hynes and Perez, {Cecilia Perret} and Bradley Connor and Holly Murphy and Prativa Pandey and Jean Vincelette and Sapha Barkati and Florescu, {Simin Aysel} and Popescu, {Corneliu Petru} and Lucille Blumberg and {De Frey}, Albie and Susan Anderson and Marc Shaw and Annemarie Hern and Israel Molina and Johnnie Yates and Hugo Siu and Valdez, {Luis Manuel} and Jean Haulman and David Roesel and Phu, {Phi Truong Hoang} and Sarah Borwein",

note = "Publisher Copyright: {\textcopyright} 2017 The Author(s).",

year = "2017",

month = jul,

day = "20",

doi = "10.1186/s12936-017-1936-3",

language = "English (US)",

volume = "16",

journal = "Malaria Journal",

issn = "1475-2875",

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TY - JOUR

T1 - Malaria after international travel

T2 - A GeoSentinel analysis, 2003-2016

AU - Angelo, Kristina M.

AU - Libman, Michael

AU - Caumes, Eric

AU - Hamer, Davidson H.

AU - Kain, Kevin C.

AU - Leder, Karin

AU - Grobusch, Martin P.

AU - Hagmann, Stefan H.

AU - Kozarsky, Phyllis

AU - Lalloo, David G.

AU - Lim, Poh Lian

AU - Patimeteeporn, Calvin

AU - Gautret, Philippe

AU - Odolini, Silvia

AU - Chappuis, François

AU - Esposito, Douglas H.

AU - Javelle, Emilie

AU - Castelli, Francesco

AU - Matteelli, Alberto

AU - Perignon, Alice

AU - Rothe, Camilla

AU - Rapp, Christoph

AU - Ficko, Cecile

AU - Schwartz, Eli

AU - Von Sonnenburg, Frank

AU - Piyaphanee, Watcharapong

AU - Silachamroon, Udomsak

AU - Boggild, Andrea

AU - Van Genderen, Perry

AU - Torresi, Joe

AU - Jensenius, Mogens

AU - Kanagawa, Shuzo

AU - Kato, Yasuyuki

AU - Yansouni, Cedric

AU - McCarthy, Anne

AU - Kelly, Paul

AU - Goorhuis, Bram

AU - López-Vélez, Rogelio

AU - Norman, Francesco

AU - Mendelson, Marc

AU - Vincent, Peter

AU - Gkrania-Klotsas, Effrossyni

AU - Warne, Ben

AU - Malvy, Denis

AU - Duvignaud, Alexandre

AU - Bottieau, Emanuel

AU - Clerinx, Joannes

AU - Coyle, Christina

AU - Àsgeirsson, Hilmer

AU - Glans, Hedvig

AU - Schlagenhauf, Patricia

AU - Weber, Rainer

AU - Mockenhaupt, Frank

AU - Harms-Zwingenberger, Gundel

AU - Beeching, Nicholas

AU - Hajek, Jan

AU - Ghesquiere, Wayne

AU - Wu, Henry

AU - Barnett, Elizabeth

AU - Hockberg, Natasha

AU - Yoshimura, Yukiriro

AU - Tachikawa, Natsuo

AU - Cahill, John

AU - McKinley, George

AU - Stauffer, William

AU - Walker, Pat

AU - Kuhn, Susan

AU - Chen, Lin

AU - Leung, Daniel

AU - Benson, Scott

AU - Larsen, Carsten Schade

AU - Wejse, Christian

AU - Field, Vanessa

AU - Licitra, Carmelo

AU - Klochko, Alena

AU - Hynes, Noreen

AU - Perez, Cecilia Perret

AU - Connor, Bradley

AU - Murphy, Holly

AU - Pandey, Prativa

AU - Vincelette, Jean

AU - Barkati, Sapha

AU - Florescu, Simin Aysel

AU - Popescu, Corneliu Petru

AU - Blumberg, Lucille

AU - De Frey, Albie

AU - Anderson, Susan

AU - Shaw, Marc

AU - Hern, Annemarie

AU - Molina, Israel

AU - Yates, Johnnie

AU - Siu, Hugo

AU - Valdez, Luis Manuel

AU - Haulman, Jean

AU - Roesel, David

AU - Phu, Phi Truong Hoang

AU - Borwein, Sarah

PY - 2017/7/20

Y1 - 2017/7/20

N2 - Background: More than 30,000 malaria cases are reported annually among international travellers. Despite improvements in malaria control, malaria continues to threaten travellers due to inaccurate perception of risk and sub-optimal pre-travel preparation. Methods: Records with a confirmed malaria diagnosis after travel from January 2003 to July 2016 were obtained from GeoSentinel, a global surveillance network of travel and tropical medicine providers that monitors travel-related morbidity. Records were excluded if exposure country was missing or unascertainable or if there was a concomitant acute diagnosis unrelated to malaria. Records were analyzed to describe the demographic and clinical characteristics of international travellers with malaria. Results: There were 5689 travellers included; 325 were children <18 years. More than half (53%) were visiting friends and relatives (VFRs). Most (83%) were exposed in sub-Saharan Africa. The median trip duration was 32 days (interquartile range 20-75); 53% did not have a pre-travel visit. More than half (62%) were hospitalized; children were hospitalized more frequently than adults (73 and 62%, respectively). Ninety-two per cent had a single Plasmodium species diagnosis, most frequently Plasmodium falciparum (4011; 76%). Travellers with P. falciparum were most frequently VFRs (60%). More than 40% of travellers with a trip duration ≤7 days had Plasmodium vivax. There were 444 (8%) travellers with severe malaria; 31 children had severe malaria. Twelve travellers died. Conclusion: Malaria remains a serious threat to international travellers. Efforts must focus on preventive strategies aimed on children and VFRs, and chemoprophylaxis access and preventive measure adherence should be emphasized.

AB - Background: More than 30,000 malaria cases are reported annually among international travellers. Despite improvements in malaria control, malaria continues to threaten travellers due to inaccurate perception of risk and sub-optimal pre-travel preparation. Methods: Records with a confirmed malaria diagnosis after travel from January 2003 to July 2016 were obtained from GeoSentinel, a global surveillance network of travel and tropical medicine providers that monitors travel-related morbidity. Records were excluded if exposure country was missing or unascertainable or if there was a concomitant acute diagnosis unrelated to malaria. Records were analyzed to describe the demographic and clinical characteristics of international travellers with malaria. Results: There were 5689 travellers included; 325 were children <18 years. More than half (53%) were visiting friends and relatives (VFRs). Most (83%) were exposed in sub-Saharan Africa. The median trip duration was 32 days (interquartile range 20-75); 53% did not have a pre-travel visit. More than half (62%) were hospitalized; children were hospitalized more frequently than adults (73 and 62%, respectively). Ninety-two per cent had a single Plasmodium species diagnosis, most frequently Plasmodium falciparum (4011; 76%). Travellers with P. falciparum were most frequently VFRs (60%). More than 40% of travellers with a trip duration ≤7 days had Plasmodium vivax. There were 444 (8%) travellers with severe malaria; 31 children had severe malaria. Twelve travellers died. Conclusion: Malaria remains a serious threat to international travellers. Efforts must focus on preventive strategies aimed on children and VFRs, and chemoprophylaxis access and preventive measure adherence should be emphasized.

KW - GeoSentinel

KW - International travel

KW - Malaria

KW - Plasmodium spp

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U2 - 10.1186/s12936-017-1936-3

DO - 10.1186/s12936-017-1936-3

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SN - 1475-2875

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JO - Malaria Journal

JF - Malaria Journal

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ER -

Malaria after international travel: A GeoSentinel analysis, 2003-2016

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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