Maintaining Translational Relevance in Animal Models of Manganese Neurotoxicity

Cherish A. Taylor, Karin Tuschl, Merle M. Nicolai, Julia Bornhorst, Priscila Gubert, Alexandre M. Varão, Michael Aschner, Donald R. Smith, Somshuvra Mukhopadhyay

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Manganese is an essential metal, but elevated brain Mn concentrations produce a parkinsonian-like movement disorder in adults and fine motor, attentional, cognitive, and intellectual deficits in children. Human Mn neurotoxicity occurs owing to elevated exposure from occupational or environmental sources, defective excretion (e.g., due to cirrhosis), or loss-of-function mutations in the Mn transporters solute carrier family 30 member 10 or solute carrier family 39 member 14. Animal models are essential to study Mn neurotoxicity, but in order to be translationally relevant, such models should utilize environmentally relevant Mn exposure regimens that reproduce changes in brain Mn concentrations and neurological function evident in human patients. Here, we provide guidelines for Mn exposure in mice, rats, nematodes, and zebrafish so that brain Mn concentrations and neurobehavioral sequelae remain directly relatable to the human phenotype.

Original languageEnglish (US)
Pages (from-to)1360-1369
Number of pages10
JournalJournal of Nutrition
Volume150
Issue number6
DOIs
StatePublished - Jun 1 2020

Keywords

  • Caenorhabditis elegans
  • SLC30A10
  • SLC39A14
  • ZIP14
  • ZnT10
  • animal models
  • manganese
  • neurotoxicity
  • zebrafish

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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    Taylor, C. A., Tuschl, K., Nicolai, M. M., Bornhorst, J., Gubert, P., Varão, A. M., Aschner, M., Smith, D. R., & Mukhopadhyay, S. (2020). Maintaining Translational Relevance in Animal Models of Manganese Neurotoxicity. Journal of Nutrition, 150(6), 1360-1369. https://doi.org/10.1093/jn/nxaa066