Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain

Louis N. Manganas, Xueying Zhang, Yao Li, Raphael D. Hazel, S. David Smith, Mark E. Wagshul, Fritz Henn, Helene Benveniste, Petar M. Djurić, Grigori Enikolopov, Mirjana Maletić-Savatić

Research output: Contribution to journalArticle

322 Scopus citations

Abstract

The identification of neural stem and progenitor cells (NPCs) by in vivo brain imaging could have important implications for diagnostic, prognostic, and therapeutic purposes. We describe a metabolic biomarker for the detection and quantification of NPCs in the human brain in vivo. We used proton nuclear magnetic resonance spectroscopy to identify and characterize a biomarker in which NPCs are enriched and demonstrated its use as a reference for monitoring neurogenesis. To detect low concentrations of NPCs in vivo, we developed a signal processing method that enabled the use of magnetic resonance spectroscopy for the analysis of the NPC biomarker in both the rodent brain and the hippocampus of live humans. Our findings thus open the possibility of investigating the role of NPCs and neurogenesis in a wide variety of human brain disorders.

Original languageEnglish (US)
Pages (from-to)980-985
Number of pages6
JournalScience
Volume318
Issue number5852
DOIs
StatePublished - Nov 2 2007
Externally publishedYes

ASJC Scopus subject areas

  • General

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    Manganas, L. N., Zhang, X., Li, Y., Hazel, R. D., Smith, S. D., Wagshul, M. E., Henn, F., Benveniste, H., Djurić, P. M., Enikolopov, G., & Maletić-Savatić, M. (2007). Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain. Science, 318(5852), 980-985. https://doi.org/10.1126/science.1147851