Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis

John S. Condeelis, Jeffrey W. Pollard

Research output: Contribution to journalArticle

1599 Citations (Scopus)

Abstract

Macrophages within the tumor microenvironment facilitate angiogenesis and extracellular-matrix breakdown and remodeling and promote tumor cell motility. Recent studies reveal that direct communication between macrophages and tumor cells leads to invasion and egress of tumor cells into the blood vessels (intravasation). Thus, macrophages are at the center of the invasion microenvironment and are an important drug target for cancer therapy.

Original languageEnglish (US)
Pages (from-to)263-266
Number of pages4
JournalCell
Volume124
Issue number2
DOIs
StatePublished - Jan 27 2006

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Macrophages
Cell Movement
Tumors
Cells
Neoplasm Metastasis
Neoplasms
Tumor Microenvironment
Blood vessels
Extracellular Matrix
Blood Vessels
Communication
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Macrophages : Obligate partners for tumor cell migration, invasion, and metastasis. / Condeelis, John S.; Pollard, Jeffrey W.

In: Cell, Vol. 124, No. 2, 27.01.2006, p. 263-266.

Research output: Contribution to journalArticle

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