Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis

John Condeelis; Jeffrey W. Pollard

doi:10.1016/j.cell.2006.01.007

Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis

John Condeelis, Jeffrey W. Pollard

Cell Biology

Research output: Contribution to journal › Short survey › peer-review

2205 Scopus citations

Abstract

Macrophages within the tumor microenvironment facilitate angiogenesis and extracellular-matrix breakdown and remodeling and promote tumor cell motility. Recent studies reveal that direct communication between macrophages and tumor cells leads to invasion and egress of tumor cells into the blood vessels (intravasation). Thus, macrophages are at the center of the invasion microenvironment and are an important drug target for cancer therapy.

Original language	English (US)
Pages (from-to)	263-266
Number of pages	4
Journal	Cell
Volume	124
Issue number	2
DOIs	https://doi.org/10.1016/j.cell.2006.01.007
State	Published - Jan 27 2006

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cell.2006.01.007

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@article{0d02d768ffca459fa8c8905f584ad173,

title = "Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis",

abstract = "Macrophages within the tumor microenvironment facilitate angiogenesis and extracellular-matrix breakdown and remodeling and promote tumor cell motility. Recent studies reveal that direct communication between macrophages and tumor cells leads to invasion and egress of tumor cells into the blood vessels (intravasation). Thus, macrophages are at the center of the invasion microenvironment and are an important drug target for cancer therapy.",

author = "John Condeelis and Pollard, {Jeffrey W.}",

note = "Funding Information: The authors were supported by CA 94173 (J.W.P.), CA 100324 (J.C. and J.W.P.), and P30 CA 13330. J.W.P. is the Sheldon and Betty E. Feinberg Senior Faculty Scholar in Cancer Research.",

year = "2006",

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day = "27",

doi = "10.1016/j.cell.2006.01.007",

language = "English (US)",

volume = "124",

pages = "263--266",

journal = "Cell",

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TY - JOUR

T1 - Macrophages

T2 - Obligate partners for tumor cell migration, invasion, and metastasis

AU - Condeelis, John

AU - Pollard, Jeffrey W.

N1 - Funding Information: The authors were supported by CA 94173 (J.W.P.), CA 100324 (J.C. and J.W.P.), and P30 CA 13330. J.W.P. is the Sheldon and Betty E. Feinberg Senior Faculty Scholar in Cancer Research.

PY - 2006/1/27

Y1 - 2006/1/27

N2 - Macrophages within the tumor microenvironment facilitate angiogenesis and extracellular-matrix breakdown and remodeling and promote tumor cell motility. Recent studies reveal that direct communication between macrophages and tumor cells leads to invasion and egress of tumor cells into the blood vessels (intravasation). Thus, macrophages are at the center of the invasion microenvironment and are an important drug target for cancer therapy.

AB - Macrophages within the tumor microenvironment facilitate angiogenesis and extracellular-matrix breakdown and remodeling and promote tumor cell motility. Recent studies reveal that direct communication between macrophages and tumor cells leads to invasion and egress of tumor cells into the blood vessels (intravasation). Thus, macrophages are at the center of the invasion microenvironment and are an important drug target for cancer therapy.

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U2 - 10.1016/j.cell.2006.01.007

DO - 10.1016/j.cell.2006.01.007

M3 - Short survey

C2 - 16439202

AN - SCOPUS:31044433663

SN - 0092-8674

VL - 124

SP - 263

EP - 266

JO - Cell

JF - Cell

IS - 2

ER -

Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis

Abstract

ASJC Scopus subject areas

UN SDGs

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