Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis

John Condeelis, Jeffrey W. Pollard

Research output: Contribution to journalShort survey

1659 Scopus citations

Abstract

Macrophages within the tumor microenvironment facilitate angiogenesis and extracellular-matrix breakdown and remodeling and promote tumor cell motility. Recent studies reveal that direct communication between macrophages and tumor cells leads to invasion and egress of tumor cells into the blood vessels (intravasation). Thus, macrophages are at the center of the invasion microenvironment and are an important drug target for cancer therapy.

Original languageEnglish (US)
Pages (from-to)263-266
Number of pages4
JournalCell
Volume124
Issue number2
DOIs
StatePublished - Jan 27 2006

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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