Macrophages and control of granulomatous inflammation in tuberculosis

J. L. Flynn, John Chan, P. L. Lin

Research output: Contribution to journalArticle

167 Citations (Scopus)

Abstract

The granuloma that forms in response to Mycobacterium tuberculosis must be carefully balanced in terms of immune responses to provide sufficient immune cell activation to inhibit the growth of the bacilli, yet modulate the inflammation to prevent pathology. There are likely many scenarios by which this balance can be reached, given the complexity of the immune responses induced by M. tuberculosis. In this review, we focus on the key role of the macrophage in balancing inflammation in the granuloma.

Original languageEnglish (US)
Pages (from-to)271-278
Number of pages8
JournalMucosal Immunology
Volume4
Issue number3
DOIs
StatePublished - May 2011

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Granuloma
Mycobacterium tuberculosis
Tuberculosis
Macrophages
Inflammation
Bacillus
Pathology
Growth

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Macrophages and control of granulomatous inflammation in tuberculosis. / Flynn, J. L.; Chan, John; Lin, P. L.

In: Mucosal Immunology, Vol. 4, No. 3, 05.2011, p. 271-278.

Research output: Contribution to journalArticle

Flynn, J. L. ; Chan, John ; Lin, P. L. / Macrophages and control of granulomatous inflammation in tuberculosis. In: Mucosal Immunology. 2011 ; Vol. 4, No. 3. pp. 271-278.
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