Macrophage-derived simian immunodeficiency virus exhibits enhanced infectivity by comparison with T-cell-derived virus

Peter J. Gaskill, Michelle Zandonatti, Tim Gilmartin, Steven R. Head, Howard S. Fox

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infect and productively replicate in macrophages and T lymphocytes. Here, we show that SIV virions derived from macrophages have higher levels of infectivity than those derived from T cells. The lower infectivity of T-cell-derived viruses is influenced by the quantity or type of mannose residues on the virion. Our results demonstrate that the cellular origin of a virus is a major factor in viral infectivity. Cell-type-specific factors in viral infectivity, and organ-specific or disease stage-specific differences in cellular derivation of virions, can be critical in the pathogenesis of HIV and AIDS.

Original languageEnglish (US)
Pages (from-to)1615-1621
Number of pages7
JournalJournal of virology
Volume82
Issue number3
DOIs
Publication statusPublished - Feb 1 2008

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ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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