Macroglobulinemia with peripheral neuropathy simulating motor neuron disease

L. P. Rowland, R. Defendini, W. Sherman, A. Hirano, M. R. Olarte, N. Latov, R. E. Lovelace, K. Inoue, E. F. Osserman

Research output: Contribution to journalArticle

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Abstract

A 48-year-old man with an IgM plasma cell dyscrasia died after 14 months of symptoms and signs typical of motor neuron disease, including widespread fasciculation and normal sensation. Two laboratory results were atypical: cerebrospinal fluid protein content of 132 mg/dl and slow motor nerve conduction. At autopsy, no loss or atrophy of anterior horn neurons was found; instead, degeneration of ventral and dorsal roots and retrograde changes of chromatolysis in motor neurons implied peripheral neuropathy. Most reported cases of neuropathy associated with plasma cell dyscrasias have been sensorimotor or purely sensory, but there have been 14 previous cases of motor disorders.

Original languageEnglish (US)
Pages (from-to)532-536
Number of pages5
JournalAnnals of Neurology
Volume11
Issue number5
StatePublished - 1982

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Waldenstrom Macroglobulinemia
Motor Neuron Disease
Paraproteinemias
Spinal Nerve Roots
Peripheral Nervous System Diseases
Anterior Horn Cells
Fasciculation
Cerebrospinal Fluid Proteins
Neural Conduction
Motor Neurons
Signs and Symptoms
Atrophy
Immunoglobulin M
Autopsy
Motor Disorders

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Rowland, L. P., Defendini, R., Sherman, W., Hirano, A., Olarte, M. R., Latov, N., ... Osserman, E. F. (1982). Macroglobulinemia with peripheral neuropathy simulating motor neuron disease. Annals of Neurology, 11(5), 532-536.

Macroglobulinemia with peripheral neuropathy simulating motor neuron disease. / Rowland, L. P.; Defendini, R.; Sherman, W.; Hirano, A.; Olarte, M. R.; Latov, N.; Lovelace, R. E.; Inoue, K.; Osserman, E. F.

In: Annals of Neurology, Vol. 11, No. 5, 1982, p. 532-536.

Research output: Contribution to journalArticle

Rowland, LP, Defendini, R, Sherman, W, Hirano, A, Olarte, MR, Latov, N, Lovelace, RE, Inoue, K & Osserman, EF 1982, 'Macroglobulinemia with peripheral neuropathy simulating motor neuron disease', Annals of Neurology, vol. 11, no. 5, pp. 532-536.
Rowland LP, Defendini R, Sherman W, Hirano A, Olarte MR, Latov N et al. Macroglobulinemia with peripheral neuropathy simulating motor neuron disease. Annals of Neurology. 1982;11(5):532-536.
Rowland, L. P. ; Defendini, R. ; Sherman, W. ; Hirano, A. ; Olarte, M. R. ; Latov, N. ; Lovelace, R. E. ; Inoue, K. ; Osserman, E. F. / Macroglobulinemia with peripheral neuropathy simulating motor neuron disease. In: Annals of Neurology. 1982 ; Vol. 11, No. 5. pp. 532-536.
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