MACH14: A multi-site collaboration on ART adherence among 14 institutions

Honghu Liu; Ira B. Wilson; Kathy Goggin; Nancy Reynolds; Jane M. Simoni; Carol E. Golin; Marc I. Rosen; Robert Gross; Glenn Wagner; Robert H. Remien; Neil Schneiderman; Judith A. Erlen; Julia H. Arnsten; David R. Bangsberg

doi:10.1007/s10461-012-0272-4

MACH14: A multi-site collaboration on ART adherence among 14 institutions

Honghu Liu, Ira B. Wilson, Kathy Goggin, Nancy Reynolds, Jane M. Simoni, Carol E. Golin, Marc I. Rosen, Robert Gross, Glenn Wagner, Robert H. Remien, Neil Schneiderman, Judith A. Erlen, Julia H. Arnsten, David R. Bangsberg

Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The integration of original data from multiple antiretroviral (ARV) adherence studies offers a promising, but little used method to generate evidence to advance the field. This paper provides an overview of the design and implementation of MACH14, a collaborative, multi-site study in which a large data system has been created for integrated analyses by pooling original data from 16 longitudinal ARV adherence studies. Studies selected met specific criteria including similar research design and data domains such as adherence measured with medication event monitoring system, psychosocial factors related to adherence behavior, and virologic and clinical outcomes. The data system created contains individual data (collected between 1997 and 2009) from 2,860 HIV patients. Collaboration helped resolve the challenges inherent in pooling data across multiple studies, yet produced a data system with strong statistical power and potentially greater capacity to address key scientific questions than possible with single-sample studies or even meta-analytic designs.

Original language	English (US)
Pages (from-to)	127-141
Number of pages	15
Journal	AIDS and Behavior
Volume	17
Issue number	1
DOIs	https://doi.org/10.1007/s10461-012-0272-4
State	Published - Jan 2013

Keywords

Adherence
Antiretroviral medication
HIV/AIDS
Individual participant data
MEMS
Multi-site

ASJC Scopus subject areas

Social Psychology
Public Health, Environmental and Occupational Health
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10461-012-0272-4

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@article{d5ffaf0ac8204fd48353053278b9728d,

title = "MACH14: A multi-site collaboration on ART adherence among 14 institutions",

abstract = "The integration of original data from multiple antiretroviral (ARV) adherence studies offers a promising, but little used method to generate evidence to advance the field. This paper provides an overview of the design and implementation of MACH14, a collaborative, multi-site study in which a large data system has been created for integrated analyses by pooling original data from 16 longitudinal ARV adherence studies. Studies selected met specific criteria including similar research design and data domains such as adherence measured with medication event monitoring system, psychosocial factors related to adherence behavior, and virologic and clinical outcomes. The data system created contains individual data (collected between 1997 and 2009) from 2,860 HIV patients. Collaboration helped resolve the challenges inherent in pooling data across multiple studies, yet produced a data system with strong statistical power and potentially greater capacity to address key scientific questions than possible with single-sample studies or even meta-analytic designs.",

keywords = "Adherence, Antiretroviral medication, HIV/AIDS, Individual participant data, MEMS, Multi-site",

author = "Honghu Liu and Wilson, {Ira B.} and Kathy Goggin and Nancy Reynolds and Simoni, {Jane M.} and Golin, {Carol E.} and Rosen, {Marc I.} and Robert Gross and Glenn Wagner and Remien, {Robert H.} and Neil Schneiderman and Erlen, {Judith A.} and Arnsten, {Julia H.} and Bangsberg, {David R.}",

note = "Funding Information: Acknowledgments This research was supported by the multi-site adherence collaboration in HIV (MACH14) Grant R01MH078773 from the National Institute of Mental Health (NIMH), Office on AIDS. The original Grants of individual participating studies are: R01DA11869, R01MH54907, 2R01NR04749, R01NR04749, R01MH68197, R01DA 13826, K23MH01862, R01MH01584, R01AI41413, R01 MH61173, NIH/NIAID AI38858, AI069419, K02DA017277, R01DA15215, NIMH P01MH49548, R01MH58986, R01MH61695, CC99-SD003, CC02-SD-003 and R01DA015679. We would like to thank all the subjects who participated in each of the individual studies. The content of the paper is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.",

year = "2013",

month = jan,

doi = "10.1007/s10461-012-0272-4",

language = "English (US)",

volume = "17",

pages = "127--141",

journal = "AIDS and Behavior",

issn = "1090-7165",

publisher = "Springer New York",

number = "1",

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T2 - A multi-site collaboration on ART adherence among 14 institutions

AU - Liu, Honghu

AU - Wilson, Ira B.

AU - Goggin, Kathy

AU - Reynolds, Nancy

AU - Simoni, Jane M.

AU - Golin, Carol E.

AU - Rosen, Marc I.

AU - Gross, Robert

AU - Wagner, Glenn

AU - Remien, Robert H.

AU - Schneiderman, Neil

AU - Erlen, Judith A.

AU - Arnsten, Julia H.

AU - Bangsberg, David R.

N1 - Funding Information: Acknowledgments This research was supported by the multi-site adherence collaboration in HIV (MACH14) Grant R01MH078773 from the National Institute of Mental Health (NIMH), Office on AIDS. The original Grants of individual participating studies are: R01DA11869, R01MH54907, 2R01NR04749, R01NR04749, R01MH68197, R01DA 13826, K23MH01862, R01MH01584, R01AI41413, R01 MH61173, NIH/NIAID AI38858, AI069419, K02DA017277, R01DA15215, NIMH P01MH49548, R01MH58986, R01MH61695, CC99-SD003, CC02-SD-003 and R01DA015679. We would like to thank all the subjects who participated in each of the individual studies. The content of the paper is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

PY - 2013/1

Y1 - 2013/1

N2 - The integration of original data from multiple antiretroviral (ARV) adherence studies offers a promising, but little used method to generate evidence to advance the field. This paper provides an overview of the design and implementation of MACH14, a collaborative, multi-site study in which a large data system has been created for integrated analyses by pooling original data from 16 longitudinal ARV adherence studies. Studies selected met specific criteria including similar research design and data domains such as adherence measured with medication event monitoring system, psychosocial factors related to adherence behavior, and virologic and clinical outcomes. The data system created contains individual data (collected between 1997 and 2009) from 2,860 HIV patients. Collaboration helped resolve the challenges inherent in pooling data across multiple studies, yet produced a data system with strong statistical power and potentially greater capacity to address key scientific questions than possible with single-sample studies or even meta-analytic designs.

AB - The integration of original data from multiple antiretroviral (ARV) adherence studies offers a promising, but little used method to generate evidence to advance the field. This paper provides an overview of the design and implementation of MACH14, a collaborative, multi-site study in which a large data system has been created for integrated analyses by pooling original data from 16 longitudinal ARV adherence studies. Studies selected met specific criteria including similar research design and data domains such as adherence measured with medication event monitoring system, psychosocial factors related to adherence behavior, and virologic and clinical outcomes. The data system created contains individual data (collected between 1997 and 2009) from 2,860 HIV patients. Collaboration helped resolve the challenges inherent in pooling data across multiple studies, yet produced a data system with strong statistical power and potentially greater capacity to address key scientific questions than possible with single-sample studies or even meta-analytic designs.

KW - Adherence

KW - Antiretroviral medication

KW - HIV/AIDS

KW - Individual participant data

KW - MEMS

KW - Multi-site

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DO - 10.1007/s10461-012-0272-4

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SN - 1090-7165

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SP - 127

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JO - AIDS and Behavior

JF - AIDS and Behavior

IS - 1

ER -

MACH14: A multi-site collaboration on ART adherence among 14 institutions

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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