Müller cells upregulate the expression of SAP97 in light-injured rat retina

Hui Ren; Gezhi Xu; Jiang Qian; Min Zhou; John Gonzales; Yingqin Ni

doi:10.1097/WNR.0b013e32833d40ab

Müller cells upregulate the expression of SAP97 in light-injured rat retina

Hui Ren, Gezhi Xu, Jiang Qian, Min Zhou, John Gonzales, Yingqin Ni

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

SAP97 is thought to play key roles in synapse assembly and synaptic plasticity. This study was carried out to determine whether it is involved in the Müller cell response to blue light injury. In light-injured rats, obvious intracellular edema in the outer retina was observed by transmission electron microscopy. The immunostaining of SAP97 was upregulated and concentrated in the Müller cell processes after photic injury, which was similar to the changes of AQP4 and the inwardly rectifying potassium channel, Kir4.1. Western blots showed that SAP97 and AQP4 protein levels were both increased on the third day after light exposure when compared with the control group (P<0.05). The upregulation of SAP97 coincides with the redistribution of AQP4 and Kir4.1 in blue light-injured rat retina.

Original language	English (US)
Pages (from-to)	832-836
Number of pages	5
Journal	NeuroReport
Volume	21
Issue number	12
DOIs	https://doi.org/10.1097/WNR.0b013e32833d40ab
State	Published - Aug 23 2010
Externally published	Yes

Keywords

Kir4.1
Müller cell
SAP97
aquaporin
blue light injury
outer retinal edema

ASJC Scopus subject areas

General Neuroscience

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10.1097/WNR.0b013e32833d40ab

Cite this

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abstract = "SAP97 is thought to play key roles in synapse assembly and synaptic plasticity. This study was carried out to determine whether it is involved in the M{\"u}ller cell response to blue light injury. In light-injured rats, obvious intracellular edema in the outer retina was observed by transmission electron microscopy. The immunostaining of SAP97 was upregulated and concentrated in the M{\"u}ller cell processes after photic injury, which was similar to the changes of AQP4 and the inwardly rectifying potassium channel, Kir4.1. Western blots showed that SAP97 and AQP4 protein levels were both increased on the third day after light exposure when compared with the control group (P<0.05). The upregulation of SAP97 coincides with the redistribution of AQP4 and Kir4.1 in blue light-injured rat retina.",

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AU - Ren, Hui

AU - Xu, Gezhi

AU - Qian, Jiang

AU - Zhou, Min

AU - Gonzales, John

AU - Ni, Yingqin

PY - 2010/8/23

Y1 - 2010/8/23

N2 - SAP97 is thought to play key roles in synapse assembly and synaptic plasticity. This study was carried out to determine whether it is involved in the Müller cell response to blue light injury. In light-injured rats, obvious intracellular edema in the outer retina was observed by transmission electron microscopy. The immunostaining of SAP97 was upregulated and concentrated in the Müller cell processes after photic injury, which was similar to the changes of AQP4 and the inwardly rectifying potassium channel, Kir4.1. Western blots showed that SAP97 and AQP4 protein levels were both increased on the third day after light exposure when compared with the control group (P<0.05). The upregulation of SAP97 coincides with the redistribution of AQP4 and Kir4.1 in blue light-injured rat retina.

AB - SAP97 is thought to play key roles in synapse assembly and synaptic plasticity. This study was carried out to determine whether it is involved in the Müller cell response to blue light injury. In light-injured rats, obvious intracellular edema in the outer retina was observed by transmission electron microscopy. The immunostaining of SAP97 was upregulated and concentrated in the Müller cell processes after photic injury, which was similar to the changes of AQP4 and the inwardly rectifying potassium channel, Kir4.1. Western blots showed that SAP97 and AQP4 protein levels were both increased on the third day after light exposure when compared with the control group (P<0.05). The upregulation of SAP97 coincides with the redistribution of AQP4 and Kir4.1 in blue light-injured rat retina.

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KW - outer retinal edema

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Müller cells upregulate the expression of SAP97 in light-injured rat retina

Abstract

Keywords

ASJC Scopus subject areas

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