Lysophosphatidic acid and apolipoprotein A1 predict increased risk of developing World Trade Center-lung injury: A nested case-control study

Jun Tsukiji, Soo Jung Cho, Ghislaine C. Echevarria, Sophia Kwon, Phillip Joseph, Edward J. Schenck, Bushra Naveed, David J. Prezant, William N. Rom, Ann Marie Schmidt, Michael D. Weiden, Anna Nolan

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Rationale: Metabolic syndrome, inflammatory and vascular injury markers measured in serum after World Trade Center (WTC) exposures predict abnormal FEV1. We hypothesized that elevated LPA levels predict FEV1<LLN. Methods: Nested case-control study of WTC-exposed firefighters. Cases had FEV1<LLN. Controls derived from the baseline cohort. Demographics, pulmonary function, serum lipids, LPA and ApoA1 were measured. Results: LPA and ApoA1 levels were higher in cases than controls and predictive of case status. LPA increased the odds by 13% while ApoA1 increased the odds by 29% of an FEV1<LLN in a multivariable model. Conclusions: Elevated LPA and ApoA1 are predictive of a significantly increased risk of developing an FEV1<LLN.

Original languageEnglish (US)
Pages (from-to)159-165
Number of pages7
JournalBiomarkers
Volume19
Issue number2
DOIs
StatePublished - Mar 2014

Fingerprint

Apolipoprotein A-I
Lung Injury
Case-Control Studies
Firefighters
Vascular System Injuries
Serum
Demography
Lipids
Lung
lysophosphatidic acid

Keywords

  • Biomarkers
  • Dyslipidemia and occupational exposure
  • World Trade Center

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

Cite this

Lysophosphatidic acid and apolipoprotein A1 predict increased risk of developing World Trade Center-lung injury : A nested case-control study. / Tsukiji, Jun; Cho, Soo Jung; Echevarria, Ghislaine C.; Kwon, Sophia; Joseph, Phillip; Schenck, Edward J.; Naveed, Bushra; Prezant, David J.; Rom, William N.; Schmidt, Ann Marie; Weiden, Michael D.; Nolan, Anna.

In: Biomarkers, Vol. 19, No. 2, 03.2014, p. 159-165.

Research output: Contribution to journalArticle

Tsukiji, J, Cho, SJ, Echevarria, GC, Kwon, S, Joseph, P, Schenck, EJ, Naveed, B, Prezant, DJ, Rom, WN, Schmidt, AM, Weiden, MD & Nolan, A 2014, 'Lysophosphatidic acid and apolipoprotein A1 predict increased risk of developing World Trade Center-lung injury: A nested case-control study', Biomarkers, vol. 19, no. 2, pp. 159-165. https://doi.org/10.3109/1354750X.2014.891047
Tsukiji, Jun ; Cho, Soo Jung ; Echevarria, Ghislaine C. ; Kwon, Sophia ; Joseph, Phillip ; Schenck, Edward J. ; Naveed, Bushra ; Prezant, David J. ; Rom, William N. ; Schmidt, Ann Marie ; Weiden, Michael D. ; Nolan, Anna. / Lysophosphatidic acid and apolipoprotein A1 predict increased risk of developing World Trade Center-lung injury : A nested case-control study. In: Biomarkers. 2014 ; Vol. 19, No. 2. pp. 159-165.
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