Lysophosphatidic acid and apolipoprotein A1 predict increased risk of developing World Trade Center-lung injury: A nested case-control study

Jun Tsukiji, Soo Jung Cho, Ghislaine C. Echevarria, Sophia Kwon, Phillip Joseph, Edward J. Schenck, Bushra Naveed, David J. Prezant, William N. Rom, Ann Marie Schmidt, Michael D. Weiden, Anna Nolan

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Rationale: Metabolic syndrome, inflammatory and vascular injury markers measured in serum after World Trade Center (WTC) exposures predict abnormal FEV1. We hypothesized that elevated LPA levels predict FEV1<LLN. Methods: Nested case-control study of WTC-exposed firefighters. Cases had FEV1<LLN. Controls derived from the baseline cohort. Demographics, pulmonary function, serum lipids, LPA and ApoA1 were measured. Results: LPA and ApoA1 levels were higher in cases than controls and predictive of case status. LPA increased the odds by 13% while ApoA1 increased the odds by 29% of an FEV1<LLN in a multivariable model. Conclusions: Elevated LPA and ApoA1 are predictive of a significantly increased risk of developing an FEV1<LLN.

Original languageEnglish (US)
Pages (from-to)159-165
Number of pages7
JournalBiomarkers
Volume19
Issue number2
DOIs
StatePublished - Mar 1 2014

Keywords

  • Biomarkers
  • Dyslipidemia and occupational exposure
  • World Trade Center

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

Fingerprint Dive into the research topics of 'Lysophosphatidic acid and apolipoprotein A1 predict increased risk of developing World Trade Center-lung injury: A nested case-control study'. Together they form a unique fingerprint.

  • Cite this

    Tsukiji, J., Cho, S. J., Echevarria, G. C., Kwon, S., Joseph, P., Schenck, E. J., Naveed, B., Prezant, D. J., Rom, W. N., Schmidt, A. M., Weiden, M. D., & Nolan, A. (2014). Lysophosphatidic acid and apolipoprotein A1 predict increased risk of developing World Trade Center-lung injury: A nested case-control study. Biomarkers, 19(2), 159-165. https://doi.org/10.3109/1354750X.2014.891047