Lymphocyte Subpopulations in Bronchopulmonary Dysplasia

Praveen Ballabh, Maciej Simm, Jaishree Kumari, Alfred N. Krauss, Ajey Jain, Peter A M Auld, Susanna Cunningham-Rundles

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A key role for inflammation in the etiology of bronchopulmonary dysplasia (BPD) has been proposed. In the present study we have evaluated lymphocyte subpopulations in 39 premature infants with respiratory distress syndrome (RDS) who did or did not develop BPD. The absolute number of lymphocytes was lower among infants with RDS who developed BPD compared with those who did not over the first two weeks of life (p < 0.020) as were percentage and absolute number of CD4+ T cells. By contrast, the proportions of CD3 +CD8+ lymphocyte cells were not statistically different between non-BPD and BPD infants. B cell percentage was significantly decreased in BPD infants only on day 7. NK "bright" cells (CD56+) were highly enriched in all RDS groups. Interestingly, the percentage of CD4+ T cells expressing CD62L was selectively reduced in BPD infants. As a whole these data suggest that reduction of CD4+ T cells and especially those important in tissue migration and immune surveillance may be a factor in the pathogenesis of BPD.

Original languageEnglish (US)
Pages (from-to)465-475
Number of pages11
JournalAmerican Journal of Perinatology
Volume20
Issue number8
DOIs
StatePublished - Nov 2003
Externally publishedYes

Fingerprint

Bronchopulmonary Dysplasia
Lymphocyte Subsets
Newborn Respiratory Distress Syndrome
T-Lymphocytes
Lymphocyte Count
Premature Infants
Natural Killer Cells
B-Lymphocytes
Lymphocytes
Inflammation

Keywords

  • Bronchopulmonary dysplasia
  • L-selectin
  • Lymphocyte subsets

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Ballabh, P., Simm, M., Kumari, J., Krauss, A. N., Jain, A., Auld, P. A. M., & Cunningham-Rundles, S. (2003). Lymphocyte Subpopulations in Bronchopulmonary Dysplasia. American Journal of Perinatology, 20(8), 465-475. https://doi.org/10.1055/s-2003-45387

Lymphocyte Subpopulations in Bronchopulmonary Dysplasia. / Ballabh, Praveen; Simm, Maciej; Kumari, Jaishree; Krauss, Alfred N.; Jain, Ajey; Auld, Peter A M; Cunningham-Rundles, Susanna.

In: American Journal of Perinatology, Vol. 20, No. 8, 11.2003, p. 465-475.

Research output: Contribution to journalArticle

Ballabh, P, Simm, M, Kumari, J, Krauss, AN, Jain, A, Auld, PAM & Cunningham-Rundles, S 2003, 'Lymphocyte Subpopulations in Bronchopulmonary Dysplasia', American Journal of Perinatology, vol. 20, no. 8, pp. 465-475. https://doi.org/10.1055/s-2003-45387
Ballabh, Praveen ; Simm, Maciej ; Kumari, Jaishree ; Krauss, Alfred N. ; Jain, Ajey ; Auld, Peter A M ; Cunningham-Rundles, Susanna. / Lymphocyte Subpopulations in Bronchopulmonary Dysplasia. In: American Journal of Perinatology. 2003 ; Vol. 20, No. 8. pp. 465-475.
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