Lymphocyte changes in favism: In vitro evidence of a modifying effect of bilirubin and hemoglobin on t-lymphocyte receptors

Gino Schilirò, Antonella Sciotto, Antonio Russo, Gaetano Bottaro, Caterina Minniti, Salvatore Musumeci, Giuseppe Russo

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Lymphocyte subpopulations were studied in 13 Sicilian glucose-6-phosphate dehydrogenase (G6PD)-deficient children during and after the hemolytic crisis due to fava bean ingestion. A statistically significant reduction of sheep-red-cell (SRC)-rosetting lymphocytes occurred in all patients during the hemolytic crisis, whereas B lymphocytes were not affected. In order to establish the possible relationship between serum changes occurring during hemolysis and reduction of SRC-rosetting lymphocytes, the effect in vitro of varying concentrations of bilirubin and hemoglobin on the rosette formation capacity of lymphocytes was studied. Both substances produced a statistically significant reduction of SRC-rosetting lymphocytes both in normal and deficient subjects. This effect showed a direct relationship with the concentrations of bilirubin and hemoglobin used and was more pronounced on lymphocytes from G6PD-deficient children. These data suggested that the reduction of SRC-rosetting lymphocytes observed during acute hemolysis of favism can be related to a modifying effect of bilirubin and hemoglobin.

Original languageEnglish (US)
Pages (from-to)230-235
Number of pages6
JournalActa Haematologica
Volume69
Issue number4
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

Keywords

  • Favism
  • G6PD deficiency
  • SRC-rosetting lymphocytes

ASJC Scopus subject areas

  • Hematology

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