Lung Mammary Metastases but Not Primary Tumors Induce Accumulation of Atypical Large Platelets and Their Chemokine Expression

Wei Zheng, Hui Zhang, Dejian Zhao, Jinghang Zhang, Jeffrey W. Pollard

Research output: Contribution to journalArticle

Abstract

Zheng et al. show a distinct type of large platelets is specifically enriched in lung metastases but not in primary tumors. Identification of this cell type provides insight into the complexity of the metastatic tumor microenvironment. It also helps clarify confusion about the origin of endothelial progenitor cells.

Original languageEnglish (US)
Pages (from-to)1747-1755.e4
JournalCell Reports
Volume29
Issue number7
DOIs
StatePublished - Nov 12 2019

Keywords

  • angiogenesis
  • breast cancer
  • chemokines
  • endothelial progenitor cells
  • megakaryocytes
  • metastasis
  • platelets
  • tumor microenvironment

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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