Lung function in rescue workers at the world trade center after 7 years

Thomas K. Aldrich, Jackson Gustave, Charles B. Hall, Hillel W. Cohen, Mayris P. Webber, Rachel Zeig-Owens, Kaitlyn Cosenza, Vasilios Christodoulou, Lara Glass, Fairouz Al-Othman, Michael D. Weiden, Kerry J. Kelly, David J. Prezant

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

BACKGROUND The terrorist attacks on the World Trade Center on September 11, 2001, exposed thousands of Fire Department of New York City (FDNY) rescue workers to dust, leading to substantial declines in lung function in the first year. We sought to determine the. longer-term effects of exposure. METHODS Using linear mixed models, we analyzed the forced expiratory volume in 1 second (FEV1) of both active and retired FDNY rescue workers on the basis of spirometry routinely performed at intervals of 12 to 18 months from March 12, 2000, to September 11, 2008. RESULTS Of the 13, 954 FDNY workers who were present at the World Trade Center between September 11, 2001, and September 24, 2001, a total of 12, 781 (91.6%) participjted in this study, contributing 61,746 quality-screened Spirometrie measurements. The median follow-up was 6.1 years for firefighters and 6.4 years for emergency-medical-services (EMS) workers. In the first year, the mean FEV1 decreased significantly for all workers, more for firefighters who had never smoked (a reduction of 439 nn; 95% confidence interval [CI], 408 to 471) than for EMS workers who had neve : smoked (a reduction of 267 ml; 95% CI, 263 to 271) (P<0.001 for both comparisons). There was little or no recovery in FEV1 during the subsequent 6 years, with a mean annualized reduction in FEV1 of 25 ml per year for firefighters and 40 ml per year for EMS workers. The proportion of workers who had never smoked and who had an FEV1 below the lower limit of the normal range increased during the first year, from 3% to 18% for firefighters and from 12% to 22% for EMS workers, stabilizing at about 13% for firefighters and 22% for EMS workers during the subsequent 6 years. CONCLUSIONS Exposure to World Trade Center dust led to large declines in FEV1 for FDNY rescue workers during the first year. Overall, these declines were persistent, without recovery over the next 6 years, leaving a substantial proportion of workers with abnormal lung function.

Original languageEnglish (US)
Pages (from-to)1263-1272
Number of pages10
JournalNew England Journal of Medicine
Volume362
Issue number14
DOIs
StatePublished - Apr 8 2010

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Firefighters
Forced Expiratory Volume
Emergency Medical Services
Lung
Dust
Confidence Intervals
Spirometry
Linear Models
Reference Values

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lung function in rescue workers at the world trade center after 7 years. / Aldrich, Thomas K.; Gustave, Jackson; Hall, Charles B.; Cohen, Hillel W.; Webber, Mayris P.; Zeig-Owens, Rachel; Cosenza, Kaitlyn; Christodoulou, Vasilios; Glass, Lara; Al-Othman, Fairouz; Weiden, Michael D.; Kelly, Kerry J.; Prezant, David J.

In: New England Journal of Medicine, Vol. 362, No. 14, 08.04.2010, p. 1263-1272.

Research output: Contribution to journalArticle

Aldrich, TK, Gustave, J, Hall, CB, Cohen, HW, Webber, MP, Zeig-Owens, R, Cosenza, K, Christodoulou, V, Glass, L, Al-Othman, F, Weiden, MD, Kelly, KJ & Prezant, DJ 2010, 'Lung function in rescue workers at the world trade center after 7 years', New England Journal of Medicine, vol. 362, no. 14, pp. 1263-1272. https://doi.org/10.1056/NEJMoa0910087
Aldrich, Thomas K. ; Gustave, Jackson ; Hall, Charles B. ; Cohen, Hillel W. ; Webber, Mayris P. ; Zeig-Owens, Rachel ; Cosenza, Kaitlyn ; Christodoulou, Vasilios ; Glass, Lara ; Al-Othman, Fairouz ; Weiden, Michael D. ; Kelly, Kerry J. ; Prezant, David J. / Lung function in rescue workers at the world trade center after 7 years. In: New England Journal of Medicine. 2010 ; Vol. 362, No. 14. pp. 1263-1272.
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abstract = "BACKGROUND The terrorist attacks on the World Trade Center on September 11, 2001, exposed thousands of Fire Department of New York City (FDNY) rescue workers to dust, leading to substantial declines in lung function in the first year. We sought to determine the. longer-term effects of exposure. METHODS Using linear mixed models, we analyzed the forced expiratory volume in 1 second (FEV1) of both active and retired FDNY rescue workers on the basis of spirometry routinely performed at intervals of 12 to 18 months from March 12, 2000, to September 11, 2008. RESULTS Of the 13, 954 FDNY workers who were present at the World Trade Center between September 11, 2001, and September 24, 2001, a total of 12, 781 (91.6{\%}) participjted in this study, contributing 61,746 quality-screened Spirometrie measurements. The median follow-up was 6.1 years for firefighters and 6.4 years for emergency-medical-services (EMS) workers. In the first year, the mean FEV1 decreased significantly for all workers, more for firefighters who had never smoked (a reduction of 439 nn; 95{\%} confidence interval [CI], 408 to 471) than for EMS workers who had neve : smoked (a reduction of 267 ml; 95{\%} CI, 263 to 271) (P<0.001 for both comparisons). There was little or no recovery in FEV1 during the subsequent 6 years, with a mean annualized reduction in FEV1 of 25 ml per year for firefighters and 40 ml per year for EMS workers. The proportion of workers who had never smoked and who had an FEV1 below the lower limit of the normal range increased during the first year, from 3{\%} to 18{\%} for firefighters and from 12{\%} to 22{\%} for EMS workers, stabilizing at about 13{\%} for firefighters and 22{\%} for EMS workers during the subsequent 6 years. CONCLUSIONS Exposure to World Trade Center dust led to large declines in FEV1 for FDNY rescue workers during the first year. Overall, these declines were persistent, without recovery over the next 6 years, leaving a substantial proportion of workers with abnormal lung function.",
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AU - Zeig-Owens, Rachel

AU - Cosenza, Kaitlyn

AU - Christodoulou, Vasilios

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N2 - BACKGROUND The terrorist attacks on the World Trade Center on September 11, 2001, exposed thousands of Fire Department of New York City (FDNY) rescue workers to dust, leading to substantial declines in lung function in the first year. We sought to determine the. longer-term effects of exposure. METHODS Using linear mixed models, we analyzed the forced expiratory volume in 1 second (FEV1) of both active and retired FDNY rescue workers on the basis of spirometry routinely performed at intervals of 12 to 18 months from March 12, 2000, to September 11, 2008. RESULTS Of the 13, 954 FDNY workers who were present at the World Trade Center between September 11, 2001, and September 24, 2001, a total of 12, 781 (91.6%) participjted in this study, contributing 61,746 quality-screened Spirometrie measurements. The median follow-up was 6.1 years for firefighters and 6.4 years for emergency-medical-services (EMS) workers. In the first year, the mean FEV1 decreased significantly for all workers, more for firefighters who had never smoked (a reduction of 439 nn; 95% confidence interval [CI], 408 to 471) than for EMS workers who had neve : smoked (a reduction of 267 ml; 95% CI, 263 to 271) (P<0.001 for both comparisons). There was little or no recovery in FEV1 during the subsequent 6 years, with a mean annualized reduction in FEV1 of 25 ml per year for firefighters and 40 ml per year for EMS workers. The proportion of workers who had never smoked and who had an FEV1 below the lower limit of the normal range increased during the first year, from 3% to 18% for firefighters and from 12% to 22% for EMS workers, stabilizing at about 13% for firefighters and 22% for EMS workers during the subsequent 6 years. CONCLUSIONS Exposure to World Trade Center dust led to large declines in FEV1 for FDNY rescue workers during the first year. Overall, these declines were persistent, without recovery over the next 6 years, leaving a substantial proportion of workers with abnormal lung function.

AB - BACKGROUND The terrorist attacks on the World Trade Center on September 11, 2001, exposed thousands of Fire Department of New York City (FDNY) rescue workers to dust, leading to substantial declines in lung function in the first year. We sought to determine the. longer-term effects of exposure. METHODS Using linear mixed models, we analyzed the forced expiratory volume in 1 second (FEV1) of both active and retired FDNY rescue workers on the basis of spirometry routinely performed at intervals of 12 to 18 months from March 12, 2000, to September 11, 2008. RESULTS Of the 13, 954 FDNY workers who were present at the World Trade Center between September 11, 2001, and September 24, 2001, a total of 12, 781 (91.6%) participjted in this study, contributing 61,746 quality-screened Spirometrie measurements. The median follow-up was 6.1 years for firefighters and 6.4 years for emergency-medical-services (EMS) workers. In the first year, the mean FEV1 decreased significantly for all workers, more for firefighters who had never smoked (a reduction of 439 nn; 95% confidence interval [CI], 408 to 471) than for EMS workers who had neve : smoked (a reduction of 267 ml; 95% CI, 263 to 271) (P<0.001 for both comparisons). There was little or no recovery in FEV1 during the subsequent 6 years, with a mean annualized reduction in FEV1 of 25 ml per year for firefighters and 40 ml per year for EMS workers. The proportion of workers who had never smoked and who had an FEV1 below the lower limit of the normal range increased during the first year, from 3% to 18% for firefighters and from 12% to 22% for EMS workers, stabilizing at about 13% for firefighters and 22% for EMS workers during the subsequent 6 years. CONCLUSIONS Exposure to World Trade Center dust led to large declines in FEV1 for FDNY rescue workers during the first year. Overall, these declines were persistent, without recovery over the next 6 years, leaving a substantial proportion of workers with abnormal lung function.

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