Lower circulating insulin-like growth factor-I is associated with better cognition in females with exceptional Longevity without compromise to muscle mass and function

Leland Perice, Nir Barzilai, Joe Verghese, Erica F. Weiss, Roee Holtzer, Pinchas Cohen, Sofiya Milman

Research output: Contribution to journalArticle

12 Scopus citations


Mutations that reduce somatotropic signaling result in improved lifespan and health-span in model organisms and humans. However, whether reduced circulating insulin-like growth factor-I (IGF-I) level is detrimental to cognitive and muscle function in older adults remains understudied. A cross-sectional analysis was performed in Ashkenazi Jews with exceptional longevity (age ≥95 years). Cognition was assessed using the Mini-Mental State Examination and muscle function with the chair rise test, grip-strength, and gait speed. Muscle mass was estimated using the skeletal muscle index. Serum IGF-I was measured with liquid chromatography mass spectrometry. In gender stratified age-adjusted logistic regression analysis, females with IGF-I levels in the first tertile had lower odds of being cognitively impaired compared to females with IGF-I levels within the upper two tertiles, OR (95% CI) 0.39 (0.19-0.82). The result remained significant after adjustment for multiple parameters. No significant association was identified in males between IGF-I and cognition. No relationship was found between IGF-I tertiles and muscle function and muscle mass in females or males. Lower circulating IGF-I is associated with better cognitive function in females with exceptional longevity, with no detriment to skeletal muscle mass and function.

Original languageEnglish (US)
Pages (from-to)2414-2424
Number of pages11
Issue number10
StatePublished - 2016



  • Cognition
  • Exceptional longevity
  • Females
  • IGF-I
  • Insulin-like growth factor-I

ASJC Scopus subject areas

  • Aging
  • Cell Biology

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