Low hypoxia inducible factor-1α (HIF-1α) expression in testicular germ cell tumors — a major reason for enhanced chemosensitivity?

Niraj Shenoy, Roxana Dronca, Fernando Quevedo, Stephen A. Boorjian, John Cheville, Brian Costello, Manish Kohli, Thomas Witzig, Lance Pagliaro

Research output: Contribution to journalArticle

Abstract

The molecular basis for enhanced chemosensitivity of testicular germ cell tumors (GCT) has been an area of great interest, as it could potentially give us therapeutic leads in other resistant malignancies. Thus far, however, the increased sensitivity of GCT has been variously attributed to multiple factors — an inability to detoxify cisplatin, a lack of export pumps, an inability to repair the DNA damage, an intact apoptotic cascade and lack of p53 mutation; but a unifying underlying etiology leading to the aforementioned processes and having a translational implication has so far been elusive. Herein, we offer evidence to support a potential significant role for the previously demonstrated low hypoxia inducible factor-1α (HIF-1α) expression in mediating the general exquisite chemosensitivity of testicular GCT, through the aforementioned processes. This molecular mechanism based hypothesis could have a significant translational implication in platinum refractory GCT as well as other platinum resistant malignancies.

Original languageEnglish (US)
Pages (from-to)374-378
Number of pages5
JournalChinese Journal of Cancer Research
Volume29
Issue number4
DOIs
StatePublished - Aug 2017
Externally publishedYes

Fingerprint

Germ Cell and Embryonal Neoplasms
Platinum
Neoplasms
Cisplatin
DNA Damage
Mutation
Research
Hypoxia
Testicular Germ Cell Tumor
Therapeutics

Keywords

  • Chemosensitivity
  • Hypoxia inducible factor-1α (HIF-1α)
  • Testicular germ cell tumor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Low hypoxia inducible factor-1α (HIF-1α) expression in testicular germ cell tumors — a major reason for enhanced chemosensitivity? / Shenoy, Niraj; Dronca, Roxana; Quevedo, Fernando; Boorjian, Stephen A.; Cheville, John; Costello, Brian; Kohli, Manish; Witzig, Thomas; Pagliaro, Lance.

In: Chinese Journal of Cancer Research, Vol. 29, No. 4, 08.2017, p. 374-378.

Research output: Contribution to journalArticle

Shenoy, Niraj ; Dronca, Roxana ; Quevedo, Fernando ; Boorjian, Stephen A. ; Cheville, John ; Costello, Brian ; Kohli, Manish ; Witzig, Thomas ; Pagliaro, Lance. / Low hypoxia inducible factor-1α (HIF-1α) expression in testicular germ cell tumors — a major reason for enhanced chemosensitivity?. In: Chinese Journal of Cancer Research. 2017 ; Vol. 29, No. 4. pp. 374-378.
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