TY - JOUR
T1 - Low hypoxia inducible factor-1α (HIF-1α) expression in testicular germ cell tumors — a major reason for enhanced chemosensitivity?
AU - Shenoy, Niraj
AU - Dronca, Roxana
AU - Quevedo, Fernando
AU - Boorjian, Stephen A.
AU - Cheville, John
AU - Costello, Brian
AU - Kohli, Manish
AU - Witzig, Thomas
AU - Pagliaro, Lance
N1 - Publisher Copyright:
© Chinese Journal of Cancer Research. All rights reserved.
PY - 2017/8
Y1 - 2017/8
N2 - The molecular basis for enhanced chemosensitivity of testicular germ cell tumors (GCT) has been an area of great interest, as it could potentially give us therapeutic leads in other resistant malignancies. Thus far, however, the increased sensitivity of GCT has been variously attributed to multiple factors — an inability to detoxify cisplatin, a lack of export pumps, an inability to repair the DNA damage, an intact apoptotic cascade and lack of p53 mutation; but a unifying underlying etiology leading to the aforementioned processes and having a translational implication has so far been elusive. Herein, we offer evidence to support a potential significant role for the previously demonstrated low hypoxia inducible factor-1α (HIF-1α) expression in mediating the general exquisite chemosensitivity of testicular GCT, through the aforementioned processes. This molecular mechanism based hypothesis could have a significant translational implication in platinum refractory GCT as well as other platinum resistant malignancies.
AB - The molecular basis for enhanced chemosensitivity of testicular germ cell tumors (GCT) has been an area of great interest, as it could potentially give us therapeutic leads in other resistant malignancies. Thus far, however, the increased sensitivity of GCT has been variously attributed to multiple factors — an inability to detoxify cisplatin, a lack of export pumps, an inability to repair the DNA damage, an intact apoptotic cascade and lack of p53 mutation; but a unifying underlying etiology leading to the aforementioned processes and having a translational implication has so far been elusive. Herein, we offer evidence to support a potential significant role for the previously demonstrated low hypoxia inducible factor-1α (HIF-1α) expression in mediating the general exquisite chemosensitivity of testicular GCT, through the aforementioned processes. This molecular mechanism based hypothesis could have a significant translational implication in platinum refractory GCT as well as other platinum resistant malignancies.
KW - Chemosensitivity
KW - Hypoxia inducible factor-1α (HIF-1α)
KW - Testicular germ cell tumor
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U2 - 10.21147/j.issn.1000-9604.2017.04.11
DO - 10.21147/j.issn.1000-9604.2017.04.11
M3 - Article
AN - SCOPUS:85028469699
SN - 1000-9604
VL - 29
SP - 374
EP - 378
JO - Chinese Journal of Cancer Research
JF - Chinese Journal of Cancer Research
IS - 4
ER -