Low-grade adenosquamous carcinoma of the breast developing around a localization wire fragment

Priyanka Handa, Samer N. Khader, Shalom S. Buchbinder, Mark Guelfguat

Research output: Contribution to journalArticle


We present the case of a 67-year-old white woman with a history of benign biopsy results in the previous 10 years before she developed low-grade adenosquamous carcinoma around a residual localization wire fragment. A possible theory of carcinogenesis may be related to reparative epithelium in a healing biopsy site that underwent squamous metaplasia; alternately, there may have been carcinogenesis related to longterm metal exposure at the wire placement site. In vitro and in vivo studies have demonstrated a link between carcinogenesis and long-term exposure to various metals. This case report raises important questions regarding carcinogenesis in the setting of long-term metal exposure and the reparative response of the body at the site of injury or biopsy.

Original languageEnglish (US)
Pages (from-to)241-247
Number of pages7
JournalLaboratory Medicine
Issue number3
StatePublished - Aug 1 2015



  • Breast carcinoma
  • Carcinogenesis
  • Localization wire
  • Mammography
  • Metaplastic breast carcinoma
  • Ultrasound

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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