Low frequency voltage clamp: Recording of voltage transients at constant average command voltage

Florian Peters, Arne Gennerich, Dirk Czesnik, Detlev Schild

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

We implemented a simple feedback system that modifies the conventional current clamp mode of a patch clamp amplifier so that transient potentials, such as action potentials and synaptic potentials, can be measured as in the usual current clamp, while the average membrane potential is kept constant at a value chosen by the user. The circuit thus works like the current clamp for high frequency signals and like a voltage clamp for low frequency signals. We delineate its transfer properties and give application examples. (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)129-135
Number of pages7
JournalJournal of Neuroscience Methods
Volume99
Issue number1-2
DOIs
StatePublished - Jun 30 2000
Externally publishedYes

Keywords

  • Current clamp
  • Patch clamp
  • Voltage clamp

ASJC Scopus subject areas

  • Neuroscience(all)

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