Low follicular fluid IL-6 levels in IVF patients are associated with increased likelihood of clinical pregnancy

Tugba Altun, Sangita Jindal, Keri Greenseid, Jun Shu, Lubna Pal

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Purpose: Relationships between follicular fluid levels of IL-6 with ovarian response and clinical pregnancy were evaluated in IVF-ET cycles. Methods: Follicular fluid was collected from ovarian follicles ≥∈14 mm, pooled for each patient, and IL-6 levels were assessed using ELISA (n∈=∈68). Relationships between IL-6 levels and IVF cycle parameters were assessed using nonparametric tests, and between IL-6 levels and clinical pregnancy using multivariable logistic regression analyses. Results: Significant positive correlations were observed between IL-6 with age (p∈=∈0.035), and IL-6 with estradiol on the day of hCG (p∈=∈0.011). On adjusted analyses, IVF cycles in patients with IL-6 levels <4.0 pg/ml (median value for the group) demonstrated an almost 4-fold increase in likelihood for clinical pregnancy (p∈=∈0.045). Conclusions: Lower follicular fluid IL-6 levels in IVF patients are associated with increased likelihood of clinical pregnancy. We hypothesize that endometrial receptivity is a likely target for any deleterious influences of elevated IL-6 levels.

Original languageEnglish (US)
Pages (from-to)245-251
Number of pages7
JournalJournal of Assisted Reproduction and Genetics
Volume28
Issue number3
DOIs
Publication statusPublished - Mar 1 2011

Keywords

  • Clinical pregnancy
  • Follicular fluid
  • IL-6
  • IVF

ASJC Scopus subject areas

  • Reproductive Medicine
  • Genetics
  • Obstetrics and Gynecology
  • Developmental Biology
  • Genetics(clinical)

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