Low eGFR is associated with dysexecutive and amnestic mild cognitive impairment

Andrea R. Zammit; Mindy J. Katz; Molly E. Zimmerman; Markus Bitzer; Richard B. Lipton

doi:10.1016/j.dadm.2014.12.002

Low eGFR is associated with dysexecutive and amnestic mild cognitive impairment

Andrea R. Zammit, Mindy J. Katz, Molly E. Zimmerman, Markus Bitzer, Richard B. Lipton

Neurology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Background: Few studies have explored the association between renal function and major subtypes of mild cognitive impairment (MCI). Methods: The sample was from the Einstein Aging Study. The estimated glomerular filtration rate (eGFR, calculated in mL/min/1.73 m² units) was classified into low (<45), moderate (45-59), and high (≥60). Separate binary logistic regression models were run to determine if eGFR is associated with amnestic MCI (aMCI) and dysexecutive MCI (dMCI). Results: Of 622 eligible participants 65 (10.5%) had low eGFR, 43 (7.1%) had aMCI, and 46 (7.6) had dMCI. Low eGFR was independently associated with dMCI and aMCI in fully adjusted models. Conclusion: At cross-section low eGFR is associated with a higher risk of both dMCI and aMCI. eGFR may contribute to the development of these cognitive states directly. Alternatively, low eGFR may be a marker for risk factors that influence both the kidney and the brain, such as coronary microvascular disease.

Original language	English (US)
Pages (from-to)	152-159
Number of pages	8
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	1
Issue number	2
DOIs	https://doi.org/10.1016/j.dadm.2014.12.002
State	Published - 2015

Keywords

Amnestic MCI
Dysexecutive MCI
Renal function

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.dadm.2014.12.002

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title = "Low eGFR is associated with dysexecutive and amnestic mild cognitive impairment",

abstract = "Background: Few studies have explored the association between renal function and major subtypes of mild cognitive impairment (MCI). Methods: The sample was from the Einstein Aging Study. The estimated glomerular filtration rate (eGFR, calculated in mL/min/1.73 m2 units) was classified into low (<45), moderate (45-59), and high (≥60). Separate binary logistic regression models were run to determine if eGFR is associated with amnestic MCI (aMCI) and dysexecutive MCI (dMCI). Results: Of 622 eligible participants 65 (10.5%) had low eGFR, 43 (7.1%) had aMCI, and 46 (7.6) had dMCI. Low eGFR was independently associated with dMCI and aMCI in fully adjusted models. Conclusion: At cross-section low eGFR is associated with a higher risk of both dMCI and aMCI. eGFR may contribute to the development of these cognitive states directly. Alternatively, low eGFR may be a marker for risk factors that influence both the kidney and the brain, such as coronary microvascular disease.",

keywords = "Amnestic MCI, Dysexecutive MCI, Renal function",

author = "Zammit, {Andrea R.} and Katz, {Mindy J.} and Zimmerman, {Molly E.} and Markus Bitzer and Lipton, {Richard B.}",

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year = "2015",

doi = "10.1016/j.dadm.2014.12.002",

language = "English (US)",

volume = "1",

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T1 - Low eGFR is associated with dysexecutive and amnestic mild cognitive impairment

AU - Zammit, Andrea R.

AU - Katz, Mindy J.

AU - Zimmerman, Molly E.

AU - Bitzer, Markus

AU - Lipton, Richard B.

PY - 2015

Y1 - 2015

N2 - Background: Few studies have explored the association between renal function and major subtypes of mild cognitive impairment (MCI). Methods: The sample was from the Einstein Aging Study. The estimated glomerular filtration rate (eGFR, calculated in mL/min/1.73 m2 units) was classified into low (<45), moderate (45-59), and high (≥60). Separate binary logistic regression models were run to determine if eGFR is associated with amnestic MCI (aMCI) and dysexecutive MCI (dMCI). Results: Of 622 eligible participants 65 (10.5%) had low eGFR, 43 (7.1%) had aMCI, and 46 (7.6) had dMCI. Low eGFR was independently associated with dMCI and aMCI in fully adjusted models. Conclusion: At cross-section low eGFR is associated with a higher risk of both dMCI and aMCI. eGFR may contribute to the development of these cognitive states directly. Alternatively, low eGFR may be a marker for risk factors that influence both the kidney and the brain, such as coronary microvascular disease.

AB - Background: Few studies have explored the association between renal function and major subtypes of mild cognitive impairment (MCI). Methods: The sample was from the Einstein Aging Study. The estimated glomerular filtration rate (eGFR, calculated in mL/min/1.73 m2 units) was classified into low (<45), moderate (45-59), and high (≥60). Separate binary logistic regression models were run to determine if eGFR is associated with amnestic MCI (aMCI) and dysexecutive MCI (dMCI). Results: Of 622 eligible participants 65 (10.5%) had low eGFR, 43 (7.1%) had aMCI, and 46 (7.6) had dMCI. Low eGFR was independently associated with dMCI and aMCI in fully adjusted models. Conclusion: At cross-section low eGFR is associated with a higher risk of both dMCI and aMCI. eGFR may contribute to the development of these cognitive states directly. Alternatively, low eGFR may be a marker for risk factors that influence both the kidney and the brain, such as coronary microvascular disease.

KW - Amnestic MCI

KW - Dysexecutive MCI

KW - Renal function

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Low eGFR is associated with dysexecutive and amnestic mild cognitive impairment

Abstract

Keywords

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UN SDGs

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