Low eGFR is associated with dysexecutive and amnestic mild cognitive impairment

Andrea R. Zammit, Mindy J. Katz, Molly E. Zimmerman, Markus Bitzer, Richard B. Lipton

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Background: Few studies have explored the association between renal function and major subtypes of mild cognitive impairment (MCI). Methods: The sample was from the Einstein Aging Study. The estimated glomerular filtration rate (eGFR, calculated in mL/min/1.73 m2 units) was classified into low (<45), moderate (45-59), and high (≥60). Separate binary logistic regression models were run to determine if eGFR is associated with amnestic MCI (aMCI) and dysexecutive MCI (dMCI). Results: Of 622 eligible participants 65 (10.5%) had low eGFR, 43 (7.1%) had aMCI, and 46 (7.6) had dMCI. Low eGFR was independently associated with dMCI and aMCI in fully adjusted models. Conclusion: At cross-section low eGFR is associated with a higher risk of both dMCI and aMCI. eGFR may contribute to the development of these cognitive states directly. Alternatively, low eGFR may be a marker for risk factors that influence both the kidney and the brain, such as coronary microvascular disease.

Original languageEnglish (US)
Pages (from-to)152-159
Number of pages8
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Issue number2
StatePublished - 2015


  • Amnestic MCI
  • Dysexecutive MCI
  • Renal function

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


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