Low-dose radiation therapy of cancer: Role of immune enhancement

Abdullah Farooque, Rohit Mathur, Amit Verma, Vandana Kaul, Anant Narayan Bhatt, Jawahar Singh Adhikari, Farhat Afrin, Saurabh Singh, Bilikere S. Dwarakanath

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations

Abstract

The efficacy of conventional radiation therapy, one of the most widely used treatment modalities of cancer, is limited by resistance of tumors as well as normal tissue toxicity. In the last decade, several studies have shown that protocols using low-dose radiation (LDR) are more effective in providing local tumor control with negligible normal tissue toxicity. LDR stimulates antioxidant capacity, repair of DNA damage, apoptosis and induction of immune responses, which might be collectively responsible for providing effective local tumor control. This article focuses on the immunostimulatory effects of LDR in in vivo models and its clinical efficacy, supporting the use of LDR regimens (alone or as adjuvant) as an anticancer treatment.

Original languageEnglish (US)
Pages (from-to)791-802
Number of pages12
JournalExpert Review of Anticancer Therapy
Volume11
Issue number5
DOIs
StatePublished - May 2011
Externally publishedYes

Keywords

  • NK cell
  • T-regulatory cell
  • cancer radiotherapy
  • dendritic cells
  • immune enhancement
  • low-dose radiation

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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