Low-dose pimozide augmentation of serotonin reuptake blockers in the treatment of trichotillomania

D. J. Stein, Eric Hollander

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

Background: There is some overlap in the phenomenology and treatment response of trichotillomania, Gilles de la Tourette's syndrome (TS), and obsessive compulsive disorder (OCD). Neuroleptics may play a role in the treatment of TS as well as refractory OCD, and the question arises whether this also holds for trichotillomania. Method: Patients with trichotillomania were treated in open clinical practice with serotonin reuptake blockers. When symptom resolution was incomplete or symptom relapse occurred, low-dose pimozide was added. Results: In six out of seven patients, the addition of pimozide to a serotonin reuptake blocker led to an improvement in hair pulling. In patients who were able to tolerate their medication, this response was sustained. Conclusion: Augmentation of serotonergic agents with dopamine blockers may play a role in the treatment of trichotillomania. Further controlled trials of pimozide augmentation in trichotillomania are needed.

Original languageEnglish (US)
Pages (from-to)123-126
Number of pages4
JournalJournal of Clinical Psychiatry
Volume53
Issue number4
StatePublished - 1992
Externally publishedYes

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Trichotillomania
Pimozide
Serotonin
Tourette Syndrome
Obsessive-Compulsive Disorder
Serotonin Agents
Therapeutics
Dopamine Antagonists
Hair
Antipsychotic Agents
Recurrence

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Low-dose pimozide augmentation of serotonin reuptake blockers in the treatment of trichotillomania. / Stein, D. J.; Hollander, Eric.

In: Journal of Clinical Psychiatry, Vol. 53, No. 4, 1992, p. 123-126.

Research output: Contribution to journalArticle

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