Low-dose acebutolol given once daily in the treatment of chronic angina pectoris

Ileana L. Pina, E. V. Smith, D. J. Weidler

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Acebutolol, a beta-1 selective beta blocker with intrinsic sympathomimetic activity has been shown to be an effective agent in chronic angina pectoris therapy, with twice or three times daily dosing. The long-term effects of 400 mg of acebutolol given only once a day versus placebo on exercise hemodynamics, ST segment depression, and rate pressure product were studied. Eleven patients (mean age, 60 ± 12 years) with hypertension and chronic angina pectoris were enrolled. Resting heart rate was not significantly altered after therapy, (80 vs 72 bpm). Objective measurements from exercise treadmill tests showed significant reduction in peak heart rate from 130 to 103 bpm, systolic blood pressure from 197 to 167 mm Hg, rate pressure product (from 25 to 18 bpm-mm Hg x 1000), and ST depression in patients receiving acebutolol compared with those receiving placebo. No significant adverse effects were reported. These data indicate that acebutolol may be efficacious as once daily therapy for chronic stable angina pectoris.

Original languageEnglish (US)
Pages (from-to)427-430
Number of pages4
JournalJournal of Clinical Pharmacology
Volume28
Issue number5
StatePublished - 1988
Externally publishedYes

Fingerprint

Acebutolol
Angina Pectoris
Stable Angina
Exercise Test
Heart Rate
Placebos
Blood Pressure
Pressure
Sympathomimetics
Therapeutics
Hemodynamics
Exercise
Hypertension

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Low-dose acebutolol given once daily in the treatment of chronic angina pectoris. / Pina, Ileana L.; Smith, E. V.; Weidler, D. J.

In: Journal of Clinical Pharmacology, Vol. 28, No. 5, 1988, p. 427-430.

Research output: Contribution to journalArticle

Pina, Ileana L. ; Smith, E. V. ; Weidler, D. J. / Low-dose acebutolol given once daily in the treatment of chronic angina pectoris. In: Journal of Clinical Pharmacology. 1988 ; Vol. 28, No. 5. pp. 427-430.
@article{af5dc915080f45a8b87cbb8104eb6658,
title = "Low-dose acebutolol given once daily in the treatment of chronic angina pectoris",
abstract = "Acebutolol, a beta-1 selective beta blocker with intrinsic sympathomimetic activity has been shown to be an effective agent in chronic angina pectoris therapy, with twice or three times daily dosing. The long-term effects of 400 mg of acebutolol given only once a day versus placebo on exercise hemodynamics, ST segment depression, and rate pressure product were studied. Eleven patients (mean age, 60 ± 12 years) with hypertension and chronic angina pectoris were enrolled. Resting heart rate was not significantly altered after therapy, (80 vs 72 bpm). Objective measurements from exercise treadmill tests showed significant reduction in peak heart rate from 130 to 103 bpm, systolic blood pressure from 197 to 167 mm Hg, rate pressure product (from 25 to 18 bpm-mm Hg x 1000), and ST depression in patients receiving acebutolol compared with those receiving placebo. No significant adverse effects were reported. These data indicate that acebutolol may be efficacious as once daily therapy for chronic stable angina pectoris.",
author = "Pina, {Ileana L.} and Smith, {E. V.} and Weidler, {D. J.}",
year = "1988",
language = "English (US)",
volume = "28",
pages = "427--430",
journal = "Journal of Clinical Pharmacology",
issn = "0091-2700",
publisher = "SAGE Publications Inc.",
number = "5",

}

TY - JOUR

T1 - Low-dose acebutolol given once daily in the treatment of chronic angina pectoris

AU - Pina, Ileana L.

AU - Smith, E. V.

AU - Weidler, D. J.

PY - 1988

Y1 - 1988

N2 - Acebutolol, a beta-1 selective beta blocker with intrinsic sympathomimetic activity has been shown to be an effective agent in chronic angina pectoris therapy, with twice or three times daily dosing. The long-term effects of 400 mg of acebutolol given only once a day versus placebo on exercise hemodynamics, ST segment depression, and rate pressure product were studied. Eleven patients (mean age, 60 ± 12 years) with hypertension and chronic angina pectoris were enrolled. Resting heart rate was not significantly altered after therapy, (80 vs 72 bpm). Objective measurements from exercise treadmill tests showed significant reduction in peak heart rate from 130 to 103 bpm, systolic blood pressure from 197 to 167 mm Hg, rate pressure product (from 25 to 18 bpm-mm Hg x 1000), and ST depression in patients receiving acebutolol compared with those receiving placebo. No significant adverse effects were reported. These data indicate that acebutolol may be efficacious as once daily therapy for chronic stable angina pectoris.

AB - Acebutolol, a beta-1 selective beta blocker with intrinsic sympathomimetic activity has been shown to be an effective agent in chronic angina pectoris therapy, with twice or three times daily dosing. The long-term effects of 400 mg of acebutolol given only once a day versus placebo on exercise hemodynamics, ST segment depression, and rate pressure product were studied. Eleven patients (mean age, 60 ± 12 years) with hypertension and chronic angina pectoris were enrolled. Resting heart rate was not significantly altered after therapy, (80 vs 72 bpm). Objective measurements from exercise treadmill tests showed significant reduction in peak heart rate from 130 to 103 bpm, systolic blood pressure from 197 to 167 mm Hg, rate pressure product (from 25 to 18 bpm-mm Hg x 1000), and ST depression in patients receiving acebutolol compared with those receiving placebo. No significant adverse effects were reported. These data indicate that acebutolol may be efficacious as once daily therapy for chronic stable angina pectoris.

UR - http://www.scopus.com/inward/record.url?scp=0024271363&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024271363&partnerID=8YFLogxK

M3 - Article

C2 - 3392240

AN - SCOPUS:0024271363

VL - 28

SP - 427

EP - 430

JO - Journal of Clinical Pharmacology

JF - Journal of Clinical Pharmacology

SN - 0091-2700

IS - 5

ER -