Low adherence achieves high HCV cure rates among people who inject drugs treated with direct-acting antiviral agents

Brianna L. Norton, Matthew J. Akiyama, Linda Agyemang, Moonseong Heo, Irene Pericot-Valverde, Alain H. Litwin

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

We measured hepatitis C virus (HCV) adherence via electronic blister packs for 145 people who inject drugs treated on-site in a methadone program. The overall sustained virologic response (SVR) rate was 96% (95% CI, 91%–98%), and overall daily adherence was 78% (95% CI, 76%–81%). Participants who achieved at least 50% adherence had an overall SVR rate of 99%, with each 5% adherence interval >50% achieving at least 90% adherence. Suboptimal adherence may still lead to cure in the direct-acting antiviral era.

Original languageEnglish (US)
Pages (from-to)1-3
Number of pages3
JournalOpen Forum Infectious Diseases
Volume7
Issue number10
DOIs
StatePublished - Oct 1 2020

Keywords

  • Adherence rates
  • HCV
  • PWID

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology

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