Low adherence achieves high HCV cure rates among people who inject drugs treated with direct-acting antiviral agents

Brianna L. Norton; Matthew J. Akiyama; Linda Agyemang; Moonseong Heo; Irene Pericot-Valverde; Alain H. Litwin

doi:10.1093/ofid/ofaa377

Low adherence achieves high HCV cure rates among people who inject drugs treated with direct-acting antiviral agents

Brianna L. Norton, Matthew J. Akiyama, Linda Agyemang, Moonseong Heo, Irene Pericot-Valverde, Alain H. Litwin

Medicine

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

We measured hepatitis C virus (HCV) adherence via electronic blister packs for 145 people who inject drugs treated on-site in a methadone program. The overall sustained virologic response (SVR) rate was 96% (95% CI, 91%–98%), and overall daily adherence was 78% (95% CI, 76%–81%). Participants who achieved at least 50% adherence had an overall SVR rate of 99%, with each 5% adherence interval >50% achieving at least 90% adherence. Suboptimal adherence may still lead to cure in the direct-acting antiviral era.

Original language	English (US)
Pages (from-to)	1-3
Number of pages	3
Journal	Open Forum Infectious Diseases
Volume	7
Issue number	10
DOIs	https://doi.org/10.1093/ofid/ofaa377
State	Published - Oct 1 2020

Keywords

Adherence rates
HCV
PWID

ASJC Scopus subject areas

Oncology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/ofid/ofaa377

Cite this

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abstract = "We measured hepatitis C virus (HCV) adherence via electronic blister packs for 145 people who inject drugs treated on-site in a methadone program. The overall sustained virologic response (SVR) rate was 96% (95% CI, 91%–98%), and overall daily adherence was 78% (95% CI, 76%–81%). Participants who achieved at least 50% adherence had an overall SVR rate of 99%, with each 5% adherence interval >50% achieving at least 90% adherence. Suboptimal adherence may still lead to cure in the direct-acting antiviral era.",

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AU - Heo, Moonseong

AU - Pericot-Valverde, Irene

AU - Litwin, Alain H.

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AB - We measured hepatitis C virus (HCV) adherence via electronic blister packs for 145 people who inject drugs treated on-site in a methadone program. The overall sustained virologic response (SVR) rate was 96% (95% CI, 91%–98%), and overall daily adherence was 78% (95% CI, 76%–81%). Participants who achieved at least 50% adherence had an overall SVR rate of 99%, with each 5% adherence interval >50% achieving at least 90% adherence. Suboptimal adherence may still lead to cure in the direct-acting antiviral era.

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Low adherence achieves high HCV cure rates among people who inject drugs treated with direct-acting antiviral agents

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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