Loss of CCAAT/enhancer binding protein δ promotes chromosomal instability

A. Mei Huang, Cristina Montagna, Shikha Sharan, Yajun Ni, Thomas Ried, Esta Sterneck

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

The transcription factor CCAAT/enhancer binding protein δ (Cebpd, also known as C/EBPδ, CRP3, CELF, NF-IL6β) is implicated in diverse cellular functions such as the acute phase response, adipocyte differentiation, learning and memory, and mammary epithelial cell growth control. Here, we report that lack of Cebpd causes genomic instability and centrosome amplifications in primary embryonic fibroblasts derived from 129S1 mice. Upon spontaneous immortalization, Cebpd-deficient fibroblasts acquire transformed features such as impaired contact inhibition and reduced serum dependence. These data identify a novel role for Cebpd in the maintenance of chromosomal stability and suggest a potential tumor suppressor function in vivo.

Original languageEnglish (US)
Pages (from-to)1549-1557
Number of pages9
JournalOncogene
Volume23
Issue number8
DOIs
StatePublished - Feb 26 2004
Externally publishedYes

Fingerprint

CCAAT-Enhancer-Binding Proteins
Chromosomal Instability
Fibroblasts
CCAAT-Enhancer-Binding Protein-beta
Contact Inhibition
Centrosome
Acute-Phase Reaction
Genomic Instability
Adipocytes
Breast
Transcription Factors
Epithelial Cells
Maintenance
Learning
Growth
Serum
Neoplasms

Keywords

  • C/EBP
  • Chromosomal rearrangements
  • Genomic instability
  • Mouse embryo fibroblast
  • Tumor suppressor

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

Cite this

Loss of CCAAT/enhancer binding protein δ promotes chromosomal instability. / Huang, A. Mei; Montagna, Cristina; Sharan, Shikha; Ni, Yajun; Ried, Thomas; Sterneck, Esta.

In: Oncogene, Vol. 23, No. 8, 26.02.2004, p. 1549-1557.

Research output: Contribution to journalArticle

Huang, AM, Montagna, C, Sharan, S, Ni, Y, Ried, T & Sterneck, E 2004, 'Loss of CCAAT/enhancer binding protein δ promotes chromosomal instability', Oncogene, vol. 23, no. 8, pp. 1549-1557. https://doi.org/10.1038/sj.onc.1207285
Huang, A. Mei ; Montagna, Cristina ; Sharan, Shikha ; Ni, Yajun ; Ried, Thomas ; Sterneck, Esta. / Loss of CCAAT/enhancer binding protein δ promotes chromosomal instability. In: Oncogene. 2004 ; Vol. 23, No. 8. pp. 1549-1557.
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