Long‐Term Follow‐Up of Patients with Nonischemic Dilated Cardiomyopathy and Ventricular Tachyarrhythmias Treated with Implantable Cardioverter Defibrillators

GREGORY FAZIO, ENRICO P. VELTRI, Gordon F. Tomaselli, RICHARD LEWIS, LAWRENCE S.C. GRIFFITH, THOMAS GUARNIERI

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

We analyzed our 10‐year cumulative experience of 40 consecutive patients with idiopathic dilated Cardiomyopathy and associated ventricular tachyarrhythmias, treated with implantable Cardioverter defibrillators. Dilated Cardiomyopathy was defined as left ventricular ejection fraction (EF) ≤50% with no defineable etiology. Patient characteristics included: 24 male, mean age 52 years, mean EF = 33%, New York Heart Association Class I–III, presenting syndrome—cardiac arrest (n = 28), syncope/near syncope (n = 12). At 2.5 years mean follow‐up, there were 16 deaths: one operative, three sudden, two incessant ventricular tachycardia/ventricular fibrillation (VT/VF), six heart failure, and four noncardiac. The actuarial mortality at 1 and 4 years was 0% and 14% for sudden death, 11% and 34% for cardiac death. The projected mortality was 52% and 78% for same time intervals (P < 0.01). No useful baseline variable predicted who would or would not receive an ICD shock in follow‐up. ICD therapy appears effective in reducing sudden death mortality in this high risk population.

Original languageEnglish (US)
Pages (from-to)1905-1910
Number of pages6
JournalPacing and Clinical Electrophysiology
Volume14
Issue number11
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

Fingerprint

Implantable Defibrillators
Dilated Cardiomyopathy
Tachycardia
Syncope
Sudden Death
Mortality
Ventricular Fibrillation
Ventricular Tachycardia
Stroke Volume
Shock
Heart Failure
Population
Therapeutics

Keywords

  • dilated Cardiomyopathy
  • implantable Cardioverter defibrillator

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Long‐Term Follow‐Up of Patients with Nonischemic Dilated Cardiomyopathy and Ventricular Tachyarrhythmias Treated with Implantable Cardioverter Defibrillators. / FAZIO, GREGORY; VELTRI, ENRICO P.; Tomaselli, Gordon F.; LEWIS, RICHARD; GRIFFITH, LAWRENCE S.C.; GUARNIERI, THOMAS.

In: Pacing and Clinical Electrophysiology, Vol. 14, No. 11, 01.01.1991, p. 1905-1910.

Research output: Contribution to journalArticle

@article{1c984da4c6a045baadd7e5626bceb9ac,
title = "Long‐Term Follow‐Up of Patients with Nonischemic Dilated Cardiomyopathy and Ventricular Tachyarrhythmias Treated with Implantable Cardioverter Defibrillators",
abstract = "We analyzed our 10‐year cumulative experience of 40 consecutive patients with idiopathic dilated Cardiomyopathy and associated ventricular tachyarrhythmias, treated with implantable Cardioverter defibrillators. Dilated Cardiomyopathy was defined as left ventricular ejection fraction (EF) ≤50{\%} with no defineable etiology. Patient characteristics included: 24 male, mean age 52 years, mean EF = 33{\%}, New York Heart Association Class I–III, presenting syndrome—cardiac arrest (n = 28), syncope/near syncope (n = 12). At 2.5 years mean follow‐up, there were 16 deaths: one operative, three sudden, two incessant ventricular tachycardia/ventricular fibrillation (VT/VF), six heart failure, and four noncardiac. The actuarial mortality at 1 and 4 years was 0{\%} and 14{\%} for sudden death, 11{\%} and 34{\%} for cardiac death. The projected mortality was 52{\%} and 78{\%} for same time intervals (P < 0.01). No useful baseline variable predicted who would or would not receive an ICD shock in follow‐up. ICD therapy appears effective in reducing sudden death mortality in this high risk population.",
keywords = "dilated Cardiomyopathy, implantable Cardioverter defibrillator",
author = "GREGORY FAZIO and VELTRI, {ENRICO P.} and Tomaselli, {Gordon F.} and RICHARD LEWIS and GRIFFITH, {LAWRENCE S.C.} and THOMAS GUARNIERI",
year = "1991",
month = "1",
day = "1",
doi = "10.1111/j.1540-8159.1991.tb02788.x",
language = "English (US)",
volume = "14",
pages = "1905--1910",
journal = "PACE - Pacing and Clinical Electrophysiology",
issn = "0147-8389",
publisher = "Wiley-Blackwell",
number = "11",

}

TY - JOUR

T1 - Long‐Term Follow‐Up of Patients with Nonischemic Dilated Cardiomyopathy and Ventricular Tachyarrhythmias Treated with Implantable Cardioverter Defibrillators

AU - FAZIO, GREGORY

AU - VELTRI, ENRICO P.

AU - Tomaselli, Gordon F.

AU - LEWIS, RICHARD

AU - GRIFFITH, LAWRENCE S.C.

AU - GUARNIERI, THOMAS

PY - 1991/1/1

Y1 - 1991/1/1

N2 - We analyzed our 10‐year cumulative experience of 40 consecutive patients with idiopathic dilated Cardiomyopathy and associated ventricular tachyarrhythmias, treated with implantable Cardioverter defibrillators. Dilated Cardiomyopathy was defined as left ventricular ejection fraction (EF) ≤50% with no defineable etiology. Patient characteristics included: 24 male, mean age 52 years, mean EF = 33%, New York Heart Association Class I–III, presenting syndrome—cardiac arrest (n = 28), syncope/near syncope (n = 12). At 2.5 years mean follow‐up, there were 16 deaths: one operative, three sudden, two incessant ventricular tachycardia/ventricular fibrillation (VT/VF), six heart failure, and four noncardiac. The actuarial mortality at 1 and 4 years was 0% and 14% for sudden death, 11% and 34% for cardiac death. The projected mortality was 52% and 78% for same time intervals (P < 0.01). No useful baseline variable predicted who would or would not receive an ICD shock in follow‐up. ICD therapy appears effective in reducing sudden death mortality in this high risk population.

AB - We analyzed our 10‐year cumulative experience of 40 consecutive patients with idiopathic dilated Cardiomyopathy and associated ventricular tachyarrhythmias, treated with implantable Cardioverter defibrillators. Dilated Cardiomyopathy was defined as left ventricular ejection fraction (EF) ≤50% with no defineable etiology. Patient characteristics included: 24 male, mean age 52 years, mean EF = 33%, New York Heart Association Class I–III, presenting syndrome—cardiac arrest (n = 28), syncope/near syncope (n = 12). At 2.5 years mean follow‐up, there were 16 deaths: one operative, three sudden, two incessant ventricular tachycardia/ventricular fibrillation (VT/VF), six heart failure, and four noncardiac. The actuarial mortality at 1 and 4 years was 0% and 14% for sudden death, 11% and 34% for cardiac death. The projected mortality was 52% and 78% for same time intervals (P < 0.01). No useful baseline variable predicted who would or would not receive an ICD shock in follow‐up. ICD therapy appears effective in reducing sudden death mortality in this high risk population.

KW - dilated Cardiomyopathy

KW - implantable Cardioverter defibrillator

UR - http://www.scopus.com/inward/record.url?scp=0025748751&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025748751&partnerID=8YFLogxK

U2 - 10.1111/j.1540-8159.1991.tb02788.x

DO - 10.1111/j.1540-8159.1991.tb02788.x

M3 - Article

VL - 14

SP - 1905

EP - 1910

JO - PACE - Pacing and Clinical Electrophysiology

JF - PACE - Pacing and Clinical Electrophysiology

SN - 0147-8389

IS - 11

ER -