Longitudinal variability of human immunodeficiency virus type 1 RNA viral load measurements by nucleic acid sequence-based amplification and nucliSens assays in a large multicenter study

M. J. Nowicki, L. Benning, J. W. Bremer, W. A. Meyer, C. Hanson, D. Brambilla, S. Silver, A. Kovacs, Kathryn Anastos, H. Minkoff, M. Young, R. Greenblatt, H. Palacio, A. Levine, M. Cohen, A. Muñoz, S. J. Gange

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Human immunodeficiency virus type 1 (HIV-1) RNA measurements were evaluated within an externally controlled multilaboratory program. Three external standards (1.5×103 to 1.5×106 copies/ml) were included in 814 assay runs by four laboratories. Results indicate that HIV-1 RNA levels can be measured with a precision equal to that of the pre-highly active antiretroviral therapy era (standard deviations, ±0.16 to 0.25 log10 units).

Original languageEnglish (US)
Pages (from-to)3760-3763
Number of pages4
JournalJournal of Clinical Microbiology
Volume39
Issue number10
DOIs
StatePublished - 2001
Externally publishedYes

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Self-Sustained Sequence Replication
Viral Load
Multicenter Studies
HIV-1
RNA
Highly Active Antiretroviral Therapy

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Longitudinal variability of human immunodeficiency virus type 1 RNA viral load measurements by nucleic acid sequence-based amplification and nucliSens assays in a large multicenter study. / Nowicki, M. J.; Benning, L.; Bremer, J. W.; Meyer, W. A.; Hanson, C.; Brambilla, D.; Silver, S.; Kovacs, A.; Anastos, Kathryn; Minkoff, H.; Young, M.; Greenblatt, R.; Palacio, H.; Levine, A.; Cohen, M.; Muñoz, A.; Gange, S. J.

In: Journal of Clinical Microbiology, Vol. 39, No. 10, 2001, p. 3760-3763.

Research output: Contribution to journalArticle

Nowicki, MJ, Benning, L, Bremer, JW, Meyer, WA, Hanson, C, Brambilla, D, Silver, S, Kovacs, A, Anastos, K, Minkoff, H, Young, M, Greenblatt, R, Palacio, H, Levine, A, Cohen, M, Muñoz, A & Gange, SJ 2001, 'Longitudinal variability of human immunodeficiency virus type 1 RNA viral load measurements by nucleic acid sequence-based amplification and nucliSens assays in a large multicenter study', Journal of Clinical Microbiology, vol. 39, no. 10, pp. 3760-3763. https://doi.org/10.1128/JCM.39.10.3760-3763.2001
Nowicki, M. J. ; Benning, L. ; Bremer, J. W. ; Meyer, W. A. ; Hanson, C. ; Brambilla, D. ; Silver, S. ; Kovacs, A. ; Anastos, Kathryn ; Minkoff, H. ; Young, M. ; Greenblatt, R. ; Palacio, H. ; Levine, A. ; Cohen, M. ; Muñoz, A. ; Gange, S. J. / Longitudinal variability of human immunodeficiency virus type 1 RNA viral load measurements by nucleic acid sequence-based amplification and nucliSens assays in a large multicenter study. In: Journal of Clinical Microbiology. 2001 ; Vol. 39, No. 10. pp. 3760-3763.
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AU - Meyer, W. A.

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AU - Silver, S.

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AU - Young, M.

AU - Greenblatt, R.

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AU - Gange, S. J.

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