Longitudinal variability of human immunodeficiency virus type 1 RNA viral load measurements by nucleic acid sequence-based amplification and nucliSens assays in a large multicenter study

M. J. Nowicki, L. Benning, J. W. Bremer, W. A. Meyer, C. Hanson, D. Brambilla, S. Silver, A. Kovacs, K. Anastos, H. Minkoff, M. Young, R. Greenblatt, H. Palacio, A. Levine, M. Cohen, A. Muñoz, S. J. Gange

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Human immunodeficiency virus type 1 (HIV-1) RNA measurements were evaluated within an externally controlled multilaboratory program. Three external standards (1.5×103 to 1.5×106 copies/ml) were included in 814 assay runs by four laboratories. Results indicate that HIV-1 RNA levels can be measured with a precision equal to that of the pre-highly active antiretroviral therapy era (standard deviations, ±0.16 to 0.25 log10 units).

Original languageEnglish (US)
Pages (from-to)3760-3763
Number of pages4
JournalJournal of Clinical Microbiology
Volume39
Issue number10
DOIs
StatePublished - Oct 22 2001
Externally publishedYes

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ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Nowicki, M. J., Benning, L., Bremer, J. W., Meyer, W. A., Hanson, C., Brambilla, D., Silver, S., Kovacs, A., Anastos, K., Minkoff, H., Young, M., Greenblatt, R., Palacio, H., Levine, A., Cohen, M., Muñoz, A., & Gange, S. J. (2001). Longitudinal variability of human immunodeficiency virus type 1 RNA viral load measurements by nucleic acid sequence-based amplification and nucliSens assays in a large multicenter study. Journal of Clinical Microbiology, 39(10), 3760-3763. https://doi.org/10.1128/JCM.39.10.3760-3763.2001