Longitudinal Changes in Lens Thickness in Myopic Children Enrolled in the Correction of Myopia Evaluation Trial (COMET)

Jane Gwiazda; Thomas T. Norton; Wei Hou; Leslie Hyman; Ruth Manny; Jane Gwiazda; Li Deng; Kenneth Grice; Christine Fortunato; Cara Weber; Alexandra Beale; David Kern; Sally Bittinger; Debanjali Ghosh; Rosemarie Smith; Rosanna Pacella; Leslie Hyman; M. Cristina Leske; Mohamed Hussein; Li Ming Dong; Melissa Fazzari; Wei Hou; Lynette Dias; Rachel Harrison; Wen Zhu; Elinor Schoenfeld; Qinghua Zhang; Ying Wang; Ahmed Yassin; Elissa Schnall; Cristi Rau; Jennifer Thomas; Marcela Wasserman; Yi Ju Chen; Sakeena Ahmed; Leanne Merill; Lauretta Passanant; Maria Rodriguez; Allison Schmertz; Ann Park; Phyllis Neuschwender; Geeta Veeraraghavan; Angela Santomarco; Laura Sisti; Lydia Seib; Donald Everett; Wendy Marsh-Tootle; Katherine Weise; Marcela Frazier; Catherine Baldwin; Carey Dillard; Kristine Becker; James Raley; Angela Rawden; Nicholas Harris; Trana Mars; Robert Rutstein; Daniel Kurtz; Erik Weissberg; Bruce Moore; Elise Harb; Robert Owens; Sheila Martin; Joanne Bolden; Justin Smith; David Kern; Sally Bittinger; Debanjali Ghosh; Benny Jaramillo; Stacy Hamlett; Laura Vasilakos; Sarah Gladstone; Chris Owens; Patricia Kowalski; Jennifer Hazelwood; Connie Crossnoe; Karen Fern; Heather Anderson; Sheila Deatherage; Charles Dudonis; Sally Henry; Jennifer McLeod; Mamie Batres; Julio Quiralte; Giselle Garza; Gabynely Solis; Joan Do; Andy Ketcham; Mitchell Scheiman; Kathleen Zinzer; Karen Pollack; Timothy Lancaster; Theresa Elliott; Mark Bernhardt; Daniel Ferrara; Jeff Miles; Scott Wilkins; Renee Wilkins; Jennifer Nicole Lynch; Dawn D’Antonio; Lindsey Lear; Sandy Dang; Charles Sporer; Mary Jameson; Abby Grossman; Mariel Torres; Heather Jones; Melissa Madigan-Carr; Theresa Sanogo; Jo Ann Bailey; Robert Hardy; Argye Hillis; Donald Mutti; Richard Stone; Carol Taylor

doi:10.3109/02713683.2015.1034372

Longitudinal Changes in Lens Thickness in Myopic Children Enrolled in the Correction of Myopia Evaluation Trial (COMET)

Jane Gwiazda, Thomas T. Norton, Wei Hou, Leslie Hyman, Ruth Manny, Jane Gwiazda, Li Deng, Kenneth Grice, Christine Fortunato, Cara Weber, Alexandra Beale, David Kern, Sally Bittinger, Debanjali Ghosh, Rosemarie Smith, Rosanna Pacella, Leslie Hyman, M. Cristina Leske, Mohamed Hussein, Li Ming DongMelissa Fazzari, Wei Hou, Lynette Dias, Rachel Harrison, Wen Zhu, Elinor Schoenfeld, Qinghua Zhang, Ying Wang, Ahmed Yassin, Elissa Schnall, Cristi Rau, Jennifer Thomas, Marcela Wasserman, Yi Ju Chen, Sakeena Ahmed, Leanne Merill, Lauretta Passanant, Maria Rodriguez, Allison Schmertz, Ann Park, Phyllis Neuschwender, Geeta Veeraraghavan, Angela Santomarco, Laura Sisti, Lydia Seib, Donald Everett, Wendy Marsh-Tootle, Katherine Weise, Marcela Frazier, Catherine Baldwin, Carey Dillard, Kristine Becker, James Raley, Angela Rawden, Nicholas Harris, Trana Mars, Robert Rutstein, Daniel Kurtz, Erik Weissberg, Bruce Moore, Elise Harb, Robert Owens, Sheila Martin, Joanne Bolden, Justin Smith, David Kern, Sally Bittinger, Debanjali Ghosh, Benny Jaramillo, Stacy Hamlett, Laura Vasilakos, Sarah Gladstone, Chris Owens, Patricia Kowalski, Jennifer Hazelwood, Connie Crossnoe, Karen Fern, Heather Anderson, Sheila Deatherage, Charles Dudonis, Sally Henry, Jennifer McLeod, Mamie Batres, Julio Quiralte, Giselle Garza, Gabynely Solis, Joan Do, Andy Ketcham, Mitchell Scheiman, Kathleen Zinzer, Karen Pollack, Timothy Lancaster, Theresa Elliott, Mark Bernhardt, Daniel Ferrara, Jeff Miles, Scott Wilkins, Renee Wilkins, Jennifer Nicole Lynch, Dawn D’Antonio, Lindsey Lear, Sandy Dang, Charles Sporer, Mary Jameson, Abby Grossman, Mariel Torres, Heather Jones, Melissa Madigan-Carr, Theresa Sanogo, Jo Ann Bailey, Robert Hardy, Argye Hillis, Donald Mutti, Richard Stone, Carol Taylor

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Purpose: To describe longitudinal changes in lens thickness in myopic children in the Correction of Myopia Evaluation Trial (COMET) and to investigate the association between these changes and myopia progression. Methods: Four-hundred sixty-nine 6 to <12-year-old children with −1.25 to −4.50 D of myopia were enrolled in COMET, a clinical trial comparing single vision lenses (SVLs) versus progressive addition lenses (PALs) for slowing myopia. Children remained in their original lenses for 5 years and then could wear contact lenses, SVLs or PALs. Myopia by cycloplegic autorefraction (Nidek ARK 700A) and ocular components, including lens thickness, by A-scan ultrasound (Sonomed A2500) were measured annually over 11 years. Analyses of lens thickness were based on right eye data from 426 children with refractions fit with Gompertz functions. Longitudinal lens thickness measurements for each participant were fit with a third-degree polynomial function, and average polynomial functions were calculated for three groups of children previously identified based on Gompertz functions: 6–7 years at baseline (n = 40), ≥8 years with progressing myopia (n = 329), and ≥8 years with non-progressing myopia (n = 56). ANOVAs were used for comparing the lens curve-based parameters among the three groups. Associations between lens and Gompertz parameters were assessed using Pearson correlations. Results: Overall, between 6 and 18 years the lenses thinned and then thickened, with the minimum value of 3.37 ± 0.15mm reached at 11.56 ± 2.04 years. The minimum lens thickness did not differ among the three myopia groups (p = 0.09), nor was it correlated with the amount of myopia at lens minimum or amount of final myopia (r’s = −0.01 and −0.03, respectively, p’s > 0.05). Conclusion: As a similar pattern of change in lens thickness with age was found in all children, whether their myopia progressed or not, these results suggest that the association of lens thinning and thickening with the course of myopia is coincidental rather than causal.

Original language	English (US)
Pages (from-to)	492-500
Number of pages	9
Journal	Current Eye Research
Volume	41
Issue number	4
DOIs	https://doi.org/10.3109/02713683.2015.1034372
State	Published - Apr 2 2016
Externally published	Yes

Keywords

Children’s vision
lens
myopia

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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10.3109/02713683.2015.1034372

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Gwiazda, J., Norton, T. T., Hou, W., Hyman, L., Manny, R., Gwiazda, J., Deng, L., Grice, K., Fortunato, C., Weber, C., Beale, A., Kern, D., Bittinger, S., Ghosh, D., Smith, R., Pacella, R., Hyman, L., Cristina Leske, M., Hussein, M., ... Taylor, C. (2016). Longitudinal Changes in Lens Thickness in Myopic Children Enrolled in the Correction of Myopia Evaluation Trial (COMET). Current Eye Research, 41(4), 492-500. https://doi.org/10.3109/02713683.2015.1034372

Gwiazda, J, Norton, TT, Hou, W, Hyman, L, Manny, R, Gwiazda, J, Deng, L, Grice, K, Fortunato, C, Weber, C, Beale, A, Kern, D, Bittinger, S, Ghosh, D, Smith, R, Pacella, R, Hyman, L, Cristina Leske, M, Hussein, M, Ming Dong, L, Fazzari, M, Hou, W, Dias, L, Harrison, R, Zhu, W, Schoenfeld, E, Zhang, Q, Wang, Y, Yassin, A, Schnall, E, Rau, C, Thomas, J, Wasserman, M, Chen, YJ, Ahmed, S, Merill, L, Passanant, L, Rodriguez, M, Schmertz, A, Park, A, Neuschwender, P, Veeraraghavan, G, Santomarco, A, Sisti, L, Seib, L, Everett, D, Marsh-Tootle, W, Weise, K, Frazier, M, Baldwin, C, Dillard, C, Becker, K, Raley, J, Rawden, A, Harris, N, Mars, T, Rutstein, R, Kurtz, D, Weissberg, E, Moore, B, Harb, E, Owens, R, Martin, S, Bolden, J, Smith, J, Kern, D, Bittinger, S, Ghosh, D, Jaramillo, B, Hamlett, S, Vasilakos, L, Gladstone, S, Owens, C, Kowalski, P, Hazelwood, J, Crossnoe, C, Fern, K, Anderson, H, Deatherage, S, Dudonis, C, Henry, S, McLeod, J, Batres, M, Quiralte, J, Garza, G, Solis, G, Do, J, Ketcham, A, Scheiman, M, Zinzer, K, Pollack, K, Lancaster, T, Elliott, T, Bernhardt, M, Ferrara, D, Miles, J, Wilkins, S, Wilkins, R, Nicole Lynch, J, D’Antonio, D, Lear, L, Dang, S, Sporer, C, Jameson, M, Grossman, A, Torres, M, Jones, H, Madigan-Carr, M, Sanogo, T, Bailey, JA, Hardy, R, Hillis, A, Mutti, D, Stone, R & Taylor, C 2016, 'Longitudinal Changes in Lens Thickness in Myopic Children Enrolled in the Correction of Myopia Evaluation Trial (COMET)', Current Eye Research, vol. 41, no. 4, pp. 492-500. https://doi.org/10.3109/02713683.2015.1034372

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title = "Longitudinal Changes in Lens Thickness in Myopic Children Enrolled in the Correction of Myopia Evaluation Trial (COMET)",

abstract = "Purpose: To describe longitudinal changes in lens thickness in myopic children in the Correction of Myopia Evaluation Trial (COMET) and to investigate the association between these changes and myopia progression. Methods: Four-hundred sixty-nine 6 to <12-year-old children with −1.25 to −4.50 D of myopia were enrolled in COMET, a clinical trial comparing single vision lenses (SVLs) versus progressive addition lenses (PALs) for slowing myopia. Children remained in their original lenses for 5 years and then could wear contact lenses, SVLs or PALs. Myopia by cycloplegic autorefraction (Nidek ARK 700A) and ocular components, including lens thickness, by A-scan ultrasound (Sonomed A2500) were measured annually over 11 years. Analyses of lens thickness were based on right eye data from 426 children with refractions fit with Gompertz functions. Longitudinal lens thickness measurements for each participant were fit with a third-degree polynomial function, and average polynomial functions were calculated for three groups of children previously identified based on Gompertz functions: 6–7 years at baseline (n = 40), ≥8 years with progressing myopia (n = 329), and ≥8 years with non-progressing myopia (n = 56). ANOVAs were used for comparing the lens curve-based parameters among the three groups. Associations between lens and Gompertz parameters were assessed using Pearson correlations. Results: Overall, between 6 and 18 years the lenses thinned and then thickened, with the minimum value of 3.37 ± 0.15mm reached at 11.56 ± 2.04 years. The minimum lens thickness did not differ among the three myopia groups (p = 0.09), nor was it correlated with the amount of myopia at lens minimum or amount of final myopia (r{\textquoteright}s = −0.01 and −0.03, respectively, p{\textquoteright}s > 0.05). Conclusion: As a similar pattern of change in lens thickness with age was found in all children, whether their myopia progressed or not, these results suggest that the association of lens thinning and thickening with the course of myopia is coincidental rather than causal.",

keywords = "Children{\textquoteright}s vision, lens, myopia",

author = "Jane Gwiazda and Norton, {Thomas T.} and Wei Hou and Leslie Hyman and Ruth Manny and Jane Gwiazda and Li Deng and Kenneth Grice and Christine Fortunato and Cara Weber and Alexandra Beale and David Kern and Sally Bittinger and Debanjali Ghosh and Rosemarie Smith and Rosanna Pacella and Leslie Hyman and {Cristina Leske}, M. and Mohamed Hussein and {Ming Dong}, Li and Melissa Fazzari and Wei Hou and Lynette Dias and Rachel Harrison and Wen Zhu and Elinor Schoenfeld and Qinghua Zhang and Ying Wang and Ahmed Yassin and Elissa Schnall and Cristi Rau and Jennifer Thomas and Marcela Wasserman and Chen, {Yi Ju} and Sakeena Ahmed and Leanne Merill and Lauretta Passanant and Maria Rodriguez and Allison Schmertz and Ann Park and Phyllis Neuschwender and Geeta Veeraraghavan and Angela Santomarco and Laura Sisti and Lydia Seib and Donald Everett and Wendy Marsh-Tootle and Katherine Weise and Marcela Frazier and Catherine Baldwin and Carey Dillard and Kristine Becker and James Raley and Angela Rawden and Nicholas Harris and Trana Mars and Robert Rutstein and Daniel Kurtz and Erik Weissberg and Bruce Moore and Elise Harb and Robert Owens and Sheila Martin and Joanne Bolden and Justin Smith and David Kern and Sally Bittinger and Debanjali Ghosh and Benny Jaramillo and Stacy Hamlett and Laura Vasilakos and Sarah Gladstone and Chris Owens and Patricia Kowalski and Jennifer Hazelwood and Connie Crossnoe and Karen Fern and Heather Anderson and Sheila Deatherage and Charles Dudonis and Sally Henry and Jennifer McLeod and Mamie Batres and Julio Quiralte and Giselle Garza and Gabynely Solis and Joan Do and Andy Ketcham and Mitchell Scheiman and Kathleen Zinzer and Karen Pollack and Timothy Lancaster and Theresa Elliott and Mark Bernhardt and Daniel Ferrara and Jeff Miles and Scott Wilkins and Renee Wilkins and {Nicole Lynch}, Jennifer and Dawn D{\textquoteright}Antonio and Lindsey Lear and Sandy Dang and Charles Sporer and Mary Jameson and Abby Grossman and Mariel Torres and Heather Jones and Melissa Madigan-Carr and Theresa Sanogo and Bailey, {Jo Ann} and Robert Hardy and Argye Hillis and Donald Mutti and Richard Stone and Carol Taylor",

note = "Publisher Copyright: {\textcopyright} 2016 Taylor & Francis, LLC.",

year = "2016",

month = apr,

day = "2",

doi = "10.3109/02713683.2015.1034372",

language = "English (US)",

volume = "41",

pages = "492--500",

journal = "Current Eye Research",

issn = "0271-3683",

publisher = "Informa Healthcare",

number = "4",

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TY - JOUR

T1 - Longitudinal Changes in Lens Thickness in Myopic Children Enrolled in the Correction of Myopia Evaluation Trial (COMET)

AU - Gwiazda, Jane

AU - Norton, Thomas T.

AU - Hou, Wei

AU - Hyman, Leslie

AU - Manny, Ruth

AU - Gwiazda, Jane

AU - Deng, Li

AU - Grice, Kenneth

AU - Fortunato, Christine

AU - Weber, Cara

AU - Beale, Alexandra

AU - Kern, David

AU - Bittinger, Sally

AU - Ghosh, Debanjali

AU - Smith, Rosemarie

AU - Pacella, Rosanna

AU - Hyman, Leslie

AU - Cristina Leske, M.

AU - Hussein, Mohamed

AU - Ming Dong, Li

AU - Fazzari, Melissa

AU - Hou, Wei

AU - Dias, Lynette

AU - Harrison, Rachel

AU - Zhu, Wen

AU - Schoenfeld, Elinor

AU - Zhang, Qinghua

AU - Wang, Ying

AU - Yassin, Ahmed

AU - Schnall, Elissa

AU - Rau, Cristi

AU - Thomas, Jennifer

AU - Wasserman, Marcela

AU - Chen, Yi Ju

AU - Ahmed, Sakeena

AU - Merill, Leanne

AU - Passanant, Lauretta

AU - Rodriguez, Maria

AU - Schmertz, Allison

AU - Park, Ann

AU - Neuschwender, Phyllis

AU - Veeraraghavan, Geeta

AU - Santomarco, Angela

AU - Sisti, Laura

AU - Seib, Lydia

AU - Everett, Donald

AU - Marsh-Tootle, Wendy

AU - Weise, Katherine

AU - Frazier, Marcela

AU - Baldwin, Catherine

AU - Dillard, Carey

AU - Becker, Kristine

AU - Raley, James

AU - Rawden, Angela

AU - Harris, Nicholas

AU - Mars, Trana

AU - Rutstein, Robert

AU - Kurtz, Daniel

AU - Weissberg, Erik

AU - Moore, Bruce

AU - Harb, Elise

AU - Owens, Robert

AU - Martin, Sheila

AU - Bolden, Joanne

AU - Smith, Justin

AU - Kern, David

AU - Bittinger, Sally

AU - Ghosh, Debanjali

AU - Jaramillo, Benny

AU - Hamlett, Stacy

AU - Vasilakos, Laura

AU - Gladstone, Sarah

AU - Owens, Chris

AU - Kowalski, Patricia

AU - Hazelwood, Jennifer

AU - Crossnoe, Connie

AU - Fern, Karen

AU - Anderson, Heather

AU - Deatherage, Sheila

AU - Dudonis, Charles

AU - Henry, Sally

AU - McLeod, Jennifer

AU - Batres, Mamie

AU - Quiralte, Julio

AU - Garza, Giselle

AU - Solis, Gabynely

AU - Do, Joan

AU - Ketcham, Andy

AU - Scheiman, Mitchell

AU - Zinzer, Kathleen

AU - Pollack, Karen

AU - Lancaster, Timothy

AU - Elliott, Theresa

AU - Bernhardt, Mark

AU - Ferrara, Daniel

AU - Miles, Jeff

AU - Wilkins, Scott

AU - Wilkins, Renee

AU - Nicole Lynch, Jennifer

AU - D’Antonio, Dawn

AU - Lear, Lindsey

AU - Dang, Sandy

AU - Sporer, Charles

AU - Jameson, Mary

AU - Grossman, Abby

AU - Torres, Mariel

AU - Jones, Heather

AU - Madigan-Carr, Melissa

AU - Sanogo, Theresa

AU - Bailey, Jo Ann

AU - Hardy, Robert

AU - Hillis, Argye

AU - Mutti, Donald

AU - Stone, Richard

AU - Taylor, Carol

PY - 2016/4/2

Y1 - 2016/4/2

N2 - Purpose: To describe longitudinal changes in lens thickness in myopic children in the Correction of Myopia Evaluation Trial (COMET) and to investigate the association between these changes and myopia progression. Methods: Four-hundred sixty-nine 6 to <12-year-old children with −1.25 to −4.50 D of myopia were enrolled in COMET, a clinical trial comparing single vision lenses (SVLs) versus progressive addition lenses (PALs) for slowing myopia. Children remained in their original lenses for 5 years and then could wear contact lenses, SVLs or PALs. Myopia by cycloplegic autorefraction (Nidek ARK 700A) and ocular components, including lens thickness, by A-scan ultrasound (Sonomed A2500) were measured annually over 11 years. Analyses of lens thickness were based on right eye data from 426 children with refractions fit with Gompertz functions. Longitudinal lens thickness measurements for each participant were fit with a third-degree polynomial function, and average polynomial functions were calculated for three groups of children previously identified based on Gompertz functions: 6–7 years at baseline (n = 40), ≥8 years with progressing myopia (n = 329), and ≥8 years with non-progressing myopia (n = 56). ANOVAs were used for comparing the lens curve-based parameters among the three groups. Associations between lens and Gompertz parameters were assessed using Pearson correlations. Results: Overall, between 6 and 18 years the lenses thinned and then thickened, with the minimum value of 3.37 ± 0.15mm reached at 11.56 ± 2.04 years. The minimum lens thickness did not differ among the three myopia groups (p = 0.09), nor was it correlated with the amount of myopia at lens minimum or amount of final myopia (r’s = −0.01 and −0.03, respectively, p’s > 0.05). Conclusion: As a similar pattern of change in lens thickness with age was found in all children, whether their myopia progressed or not, these results suggest that the association of lens thinning and thickening with the course of myopia is coincidental rather than causal.

AB - Purpose: To describe longitudinal changes in lens thickness in myopic children in the Correction of Myopia Evaluation Trial (COMET) and to investigate the association between these changes and myopia progression. Methods: Four-hundred sixty-nine 6 to <12-year-old children with −1.25 to −4.50 D of myopia were enrolled in COMET, a clinical trial comparing single vision lenses (SVLs) versus progressive addition lenses (PALs) for slowing myopia. Children remained in their original lenses for 5 years and then could wear contact lenses, SVLs or PALs. Myopia by cycloplegic autorefraction (Nidek ARK 700A) and ocular components, including lens thickness, by A-scan ultrasound (Sonomed A2500) were measured annually over 11 years. Analyses of lens thickness were based on right eye data from 426 children with refractions fit with Gompertz functions. Longitudinal lens thickness measurements for each participant were fit with a third-degree polynomial function, and average polynomial functions were calculated for three groups of children previously identified based on Gompertz functions: 6–7 years at baseline (n = 40), ≥8 years with progressing myopia (n = 329), and ≥8 years with non-progressing myopia (n = 56). ANOVAs were used for comparing the lens curve-based parameters among the three groups. Associations between lens and Gompertz parameters were assessed using Pearson correlations. Results: Overall, between 6 and 18 years the lenses thinned and then thickened, with the minimum value of 3.37 ± 0.15mm reached at 11.56 ± 2.04 years. The minimum lens thickness did not differ among the three myopia groups (p = 0.09), nor was it correlated with the amount of myopia at lens minimum or amount of final myopia (r’s = −0.01 and −0.03, respectively, p’s > 0.05). Conclusion: As a similar pattern of change in lens thickness with age was found in all children, whether their myopia progressed or not, these results suggest that the association of lens thinning and thickening with the course of myopia is coincidental rather than causal.

KW - Children’s vision

KW - lens

KW - myopia

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DO - 10.3109/02713683.2015.1034372

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SN - 0271-3683

VL - 41

SP - 492

EP - 500

JO - Current Eye Research

JF - Current Eye Research

IS - 4

ER -

Longitudinal Changes in Lens Thickness in Myopic Children Enrolled in the Correction of Myopia Evaluation Trial (COMET)

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