Longitudinal Changes in Lens Thickness in Myopic Children Enrolled in the Correction of Myopia Evaluation Trial (COMET)

Jane Gwiazda, Thomas T. Norton, Wei Hou, Leslie Hyman, Ruth Manny, Jane Gwiazda, Thomas Norton, Li Deng, Kenneth Grice, Christine Fortunato, Cara Weber, Alexandra Beale, David Kern, Sally Bittinger, Debanjali Ghosh, Rosemarie Smith, Rosanna Pacella, Leslie Hyman, M. Cristina Leske, Mohamed HusseinLi Ming Dong, Melissa Fazzari, Wei Hou, Lynette Dias, Rachel Harrison, Wen Zhu, Elinor Schoenfeld, Qinghua Zhang, Ying Wang, Ahmed Yassin, Elissa Schnall, Cristi Rau, Jennifer Thomas, Marcela Wasserman, Yi Ju Chen, Sakeena Ahmed, Leanne Merill, Lauretta Passanant, Maria Rodriguez, Allison Schmertz, Ann Park, Phyllis Neuschwender, Geeta Veeraraghavan, Angela Santomarco, Laura Sisti, Lydia Seib, Donald Everett, Wendy Marsh-Tootle, Katherine Weise, Marcela Frazier, Catherine Baldwin, Carey Dillard, Kristine Becker, James Raley, Angela Rawden, Nicholas Harris, Trana Mars, Robert Rutstein, Daniel Kurtz, Erik Weissberg, Bruce Moore, Elise Harb, Robert Owens, Sheila Martin, Joanne Bolden, Justin Smith, David Kern, Sally Bittinger, Debanjali Ghosh, Benny Jaramillo, Stacy Hamlett, Laura Vasilakos, Sarah Gladstone, Chris Owens, Patricia Kowalski, Jennifer Hazelwood, Ruth Manny, Connie Crossnoe, Karen Fern, Heather Anderson, Sheila Deatherage, Charles Dudonis, Sally Henry, Jennifer McLeod, Mamie Batres, Julio Quiralte, Giselle Garza, Gabynely Solis, Joan Do, Andy Ketcham, Mitchell Scheiman, Kathleen Zinzer, Karen Pollack, Timothy Lancaster, Theresa Elliott, Mark Bernhardt, Daniel Ferrara, Jeff Miles, Scott Wilkins, Renee Wilkins, Jennifer Nicole Lynch, Dawn D’Antonio, Lindsey Lear, Sandy Dang, Charles Sporer, Mary Jameson, Abby Grossman, Mariel Torres, Heather Jones, Melissa Madigan-Carr, Theresa Sanogo, Jo Ann Bailey, Robert Hardy, Argye Hillis, Donald Mutti, Richard Stone, Carol Taylor

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Purpose: To describe longitudinal changes in lens thickness in myopic children in the Correction of Myopia Evaluation Trial (COMET) and to investigate the association between these changes and myopia progression. Methods: Four-hundred sixty-nine 6 to <12-year-old children with −1.25 to −4.50 D of myopia were enrolled in COMET, a clinical trial comparing single vision lenses (SVLs) versus progressive addition lenses (PALs) for slowing myopia. Children remained in their original lenses for 5 years and then could wear contact lenses, SVLs or PALs. Myopia by cycloplegic autorefraction (Nidek ARK 700A) and ocular components, including lens thickness, by A-scan ultrasound (Sonomed A2500) were measured annually over 11 years. Analyses of lens thickness were based on right eye data from 426 children with refractions fit with Gompertz functions. Longitudinal lens thickness measurements for each participant were fit with a third-degree polynomial function, and average polynomial functions were calculated for three groups of children previously identified based on Gompertz functions: 6–7 years at baseline (n = 40), ≥8 years with progressing myopia (n = 329), and ≥8 years with non-progressing myopia (n = 56). ANOVAs were used for comparing the lens curve-based parameters among the three groups. Associations between lens and Gompertz parameters were assessed using Pearson correlations. Results: Overall, between 6 and 18 years the lenses thinned and then thickened, with the minimum value of 3.37 ± 0.15mm reached at 11.56 ± 2.04 years. The minimum lens thickness did not differ among the three myopia groups (p = 0.09), nor was it correlated with the amount of myopia at lens minimum or amount of final myopia (r’s = −0.01 and −0.03, respectively, p’s > 0.05). Conclusion: As a similar pattern of change in lens thickness with age was found in all children, whether their myopia progressed or not, these results suggest that the association of lens thinning and thickening with the course of myopia is coincidental rather than causal.

Original languageEnglish (US)
Pages (from-to)492-500
Number of pages9
JournalCurrent Eye Research
Issue number4
StatePublished - Apr 2 2016
Externally publishedYes


  • Children’s vision
  • lens
  • myopia

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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