Longitudinal association of measures of adiposity with serum antioxidant concentrations in postmenopausal women

G. C. Kabat, Moonseong Heo, H. M. Ochs-Balcom, M. S. Leboff, Yasmin Mossavar-Rahmani, L. L. Adams-Campbell, R. Nassir, J. Ard, O. Zaslavsky, Thomas E. Rohan

Research output: Contribution to journalArticle

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Abstract

Background/Objectives:The relationship between obesity and circulating levels of antioxidants is poorly understood. Most studies that have examined the association of adiposity with blood or tissue concentrations of antioxidant micronutrients have been cross-sectional, and few have compared the associations for indices of overall obesity and central obesity. Our aim was to prospectively examine the longitudinal association of body mass index (BMI), waist circumference (WC), waist circumference-height ratio (WCHtR) and waist-hip ratio (WHR) with major serum antioxidants in a population of postmenopausal women.Subjects/Methods:We used a subsample of participants in the Women's Health Initiative aged 50-79 years at entry with available fasting blood samples and anthropometric measurements obtained at multiple time points over 12.8 years of follow-up (N=2672). Blood samples were used to measure α-carotene, β-carotene, β-cryptoxanthin, lutein+zeaxanthin, α-tocopherol, γ-tocopherol and retinol at baseline, and at years 1, 3 and 6. We used mixed-effects linear regression analyses to examine associations between anthropometric measures and serum antioxidants at baseline and over time, controlling for covariates.Results:In longitudinal analyses, carotenoids, and particularly β-carotene, were strongly and inversely associated with BMI, WC and WCHtR and less so with WHR. α-Tocopherol showed a strong positive association with WHR but not with other anthropometric measures, whereas γ-tocopherol was positively and strongly associated with BMI, WC, WCHtR and less so with WHR. Retinol was positively associated with WHR. The inverse association of several carotenoids with anthropometric measures was stronger in never and former smokers compared with current smokers and in women without the metabolic syndrome. The inverse association of carotenoids with obesity measures may reflect reduced micronutrient concentrations owing to inflammation associated with obesity.Conclusions:In the present study, the strongest observed associations between anthropometric variables and micronutrients were an inverse association of WC with serum β-carotene and a positive association of WC with γ-tocopherol.

Original languageEnglish (US)
Pages (from-to)47-53
Number of pages7
JournalEuropean Journal of Clinical Nutrition
Volume70
Issue number1
DOIs
StatePublished - Jan 1 2016

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Adiposity
Waist Circumference
Carotenoids
Antioxidants
Waist-Hip Ratio
Tocopherols
Serum
Micronutrients
Obesity
Body Mass Index
Vitamin A
Lutein
Abdominal Obesity
Women's Health
Linear Models
Fasting
Regression Analysis
Inflammation
Population

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Longitudinal association of measures of adiposity with serum antioxidant concentrations in postmenopausal women. / Kabat, G. C.; Heo, Moonseong; Ochs-Balcom, H. M.; Leboff, M. S.; Mossavar-Rahmani, Yasmin; Adams-Campbell, L. L.; Nassir, R.; Ard, J.; Zaslavsky, O.; Rohan, Thomas E.

In: European Journal of Clinical Nutrition, Vol. 70, No. 1, 01.01.2016, p. 47-53.

Research output: Contribution to journalArticle

Kabat, G. C. ; Heo, Moonseong ; Ochs-Balcom, H. M. ; Leboff, M. S. ; Mossavar-Rahmani, Yasmin ; Adams-Campbell, L. L. ; Nassir, R. ; Ard, J. ; Zaslavsky, O. ; Rohan, Thomas E. / Longitudinal association of measures of adiposity with serum antioxidant concentrations in postmenopausal women. In: European Journal of Clinical Nutrition. 2016 ; Vol. 70, No. 1. pp. 47-53.
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abstract = "Background/Objectives:The relationship between obesity and circulating levels of antioxidants is poorly understood. Most studies that have examined the association of adiposity with blood or tissue concentrations of antioxidant micronutrients have been cross-sectional, and few have compared the associations for indices of overall obesity and central obesity. Our aim was to prospectively examine the longitudinal association of body mass index (BMI), waist circumference (WC), waist circumference-height ratio (WCHtR) and waist-hip ratio (WHR) with major serum antioxidants in a population of postmenopausal women.Subjects/Methods:We used a subsample of participants in the Women's Health Initiative aged 50-79 years at entry with available fasting blood samples and anthropometric measurements obtained at multiple time points over 12.8 years of follow-up (N=2672). Blood samples were used to measure α-carotene, β-carotene, β-cryptoxanthin, lutein+zeaxanthin, α-tocopherol, γ-tocopherol and retinol at baseline, and at years 1, 3 and 6. We used mixed-effects linear regression analyses to examine associations between anthropometric measures and serum antioxidants at baseline and over time, controlling for covariates.Results:In longitudinal analyses, carotenoids, and particularly β-carotene, were strongly and inversely associated with BMI, WC and WCHtR and less so with WHR. α-Tocopherol showed a strong positive association with WHR but not with other anthropometric measures, whereas γ-tocopherol was positively and strongly associated with BMI, WC, WCHtR and less so with WHR. Retinol was positively associated with WHR. The inverse association of several carotenoids with anthropometric measures was stronger in never and former smokers compared with current smokers and in women without the metabolic syndrome. The inverse association of carotenoids with obesity measures may reflect reduced micronutrient concentrations owing to inflammation associated with obesity.Conclusions:In the present study, the strongest observed associations between anthropometric variables and micronutrients were an inverse association of WC with serum β-carotene and a positive association of WC with γ-tocopherol.",
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AU - Kabat, G. C.

AU - Heo, Moonseong

AU - Ochs-Balcom, H. M.

AU - Leboff, M. S.

AU - Mossavar-Rahmani, Yasmin

AU - Adams-Campbell, L. L.

AU - Nassir, R.

AU - Ard, J.

AU - Zaslavsky, O.

AU - Rohan, Thomas E.

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N2 - Background/Objectives:The relationship between obesity and circulating levels of antioxidants is poorly understood. Most studies that have examined the association of adiposity with blood or tissue concentrations of antioxidant micronutrients have been cross-sectional, and few have compared the associations for indices of overall obesity and central obesity. Our aim was to prospectively examine the longitudinal association of body mass index (BMI), waist circumference (WC), waist circumference-height ratio (WCHtR) and waist-hip ratio (WHR) with major serum antioxidants in a population of postmenopausal women.Subjects/Methods:We used a subsample of participants in the Women's Health Initiative aged 50-79 years at entry with available fasting blood samples and anthropometric measurements obtained at multiple time points over 12.8 years of follow-up (N=2672). Blood samples were used to measure α-carotene, β-carotene, β-cryptoxanthin, lutein+zeaxanthin, α-tocopherol, γ-tocopherol and retinol at baseline, and at years 1, 3 and 6. We used mixed-effects linear regression analyses to examine associations between anthropometric measures and serum antioxidants at baseline and over time, controlling for covariates.Results:In longitudinal analyses, carotenoids, and particularly β-carotene, were strongly and inversely associated with BMI, WC and WCHtR and less so with WHR. α-Tocopherol showed a strong positive association with WHR but not with other anthropometric measures, whereas γ-tocopherol was positively and strongly associated with BMI, WC, WCHtR and less so with WHR. Retinol was positively associated with WHR. The inverse association of several carotenoids with anthropometric measures was stronger in never and former smokers compared with current smokers and in women without the metabolic syndrome. The inverse association of carotenoids with obesity measures may reflect reduced micronutrient concentrations owing to inflammation associated with obesity.Conclusions:In the present study, the strongest observed associations between anthropometric variables and micronutrients were an inverse association of WC with serum β-carotene and a positive association of WC with γ-tocopherol.

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