TY - JOUR
T1 - Longitudinal association of alcohol use with HIV disease progression and psychological health of women with HIV
AU - Ghebremichael, Musie
AU - Paintsil, Elijah
AU - Ickovics, Jeannette R.
AU - Vlahov, David
AU - Schuman, Paula
AU - Boland, Robert
AU - Schoenbaum, Ellie
AU - Moore, Janet
AU - Zhang, Heping
N1 - Funding Information:
We thank the study staff at each site, and all of the women who participated in HERS. This study was supported by the National Institute of Health (T32-MH014235, K02-DA017713, R01-DA076750-02, and 5 U01-DA017387-03S1), and the Centers for Disease Control and Prevention (U64/CU106795, U64/CU200714, U64/CU306802, and U64/CU506831).
PY - 2009/7
Y1 - 2009/7
N2 - We evaluated the association of alcohol consumption and depression, and their effects on HIV disease progression among women with HIV. The study included 871 women with HIV who were recruited from 1993-1995 in four US cities. The participants had physical examination, medical record extraction, and venipuncture, CD4+T-cell counts determination, measurement of depression symptoms (using the self-report Center for Epidemiological Studies-Depression Scale), and alcohol use assessment at enrollment, and semiannually until March 2000. Multilevel random coefficient ordinal models as well as multilevel models with joint responses were used in the analysis. There was no significant association between level of alcohol use and CD4+ T-cell counts. When participants were stratified by antiretroviral therapy (ART) use, the association between alcohol and CD4+ T-cell did not reach statistical significance. The association between alcohol consumption and depression was significant (p<0.001). Depression had a significant negative effect on CD4+ T-cell counts over time regardless of ART use. Our findings suggest that alcohol consumption has a direct association with depression. Moreover, depression is associated with HIV disease progression. Our findings have implications for the provision of alcohol use interventions and psychological resources to improve the health of women with HIV.
AB - We evaluated the association of alcohol consumption and depression, and their effects on HIV disease progression among women with HIV. The study included 871 women with HIV who were recruited from 1993-1995 in four US cities. The participants had physical examination, medical record extraction, and venipuncture, CD4+T-cell counts determination, measurement of depression symptoms (using the self-report Center for Epidemiological Studies-Depression Scale), and alcohol use assessment at enrollment, and semiannually until March 2000. Multilevel random coefficient ordinal models as well as multilevel models with joint responses were used in the analysis. There was no significant association between level of alcohol use and CD4+ T-cell counts. When participants were stratified by antiretroviral therapy (ART) use, the association between alcohol and CD4+ T-cell did not reach statistical significance. The association between alcohol consumption and depression was significant (p<0.001). Depression had a significant negative effect on CD4+ T-cell counts over time regardless of ART use. Our findings suggest that alcohol consumption has a direct association with depression. Moreover, depression is associated with HIV disease progression. Our findings have implications for the provision of alcohol use interventions and psychological resources to improve the health of women with HIV.
KW - Alcohol use
KW - CD4+T-cells
KW - Depression
KW - HIV/AIDS
KW - Multilevel longitudinal models
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U2 - 10.1080/09540120802537864
DO - 10.1080/09540120802537864
M3 - Article
C2 - 20024739
AN - SCOPUS:70450202851
SN - 0954-0121
VL - 21
SP - 834
EP - 841
JO - AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
JF - AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
IS - 7
ER -
